Expression of surfactant proteins SP-A and SP-D in murine decidua and immunomodulatory effects on decidual macrophages.

abstract：:Activated macrophages have various characteristics in common with exudate and resident macrophages, but the ability to inhibit intracellular proliferation of the protozoa Toxoplasma gondii, the expression of Ia antigen and the capacity to produce H2O2 varies among these cells. Assessment of these features of macrophag...

journal_title：Immunobiology

authors： Nibbering PH,Langermans JA,van de Gevel JS,van der Hulst MB,van Furth R

更新日期：1991-12-01 00:00:00

abstract：:We investigated the effects of ML I and its isolated chains, A and B, in regard to selected functions of phagocytes (human granulocytes, paraffin-oil stimulated M phi from guinea pigs). On these cells, ML I has no cytotoxic effect between 10(-14) and 10(-8) (trypan blue exclusion and ethidium bromide exclusion). Over ...

journal_title：Immunobiology

authors： Metzner G,Franz H,Kindt A,Fahlbusch B,Süss J

更新日期：1985-07-01 00:00:00

abstract：:Ribosomal 30S and 50S subunits as well as total proteins from the large subunit of E. coli ribosomes were found to be potent mitogens for both human adult and cord blood lymphocytes. On the other hand, the RNA fraction of the 50S subunit had only a weak stimulatory capacity suggesting that the protein moiety contains ...

journal_title：Immunobiology

authors： Sieber G,Rühl H

更新日期：1980-01-01 00:00:00

abstract：:Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...

journal_title：Immunobiology

authors： Joncourt F,Bettens F,Kristensen F,de Weck AL

更新日期：1981-06-01 00:00:00

abstract：PROBLEM:NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. METHODS OF STUDY:Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present stud...

journal_title：Immunobiology

authors： Dons'koi BV,Chernyshov VP,Sirenko VY,Strelko GV,Osypchuk DV

更新日期：2014-03-01 00:00:00

abstract：:Macrophages are key players not only during initiation of inflammation but also during its resolution. This is achieved by their high functional plasticity and the demand to recognize an enormous repertoire of danger signals and cytokines/chemokines derived from adaptive immune cells. Studies predominantly conducted o...

journal_title：Immunobiology

authors： Ley S,Weigert A,Brüne B

更新日期：2010-09-01 00:00:00

abstract：:The anticonvulsant drug phenytoin, in less than cytotoxic concentrations, caused significant reductions in Ig secretion by unstimulated or EBV-stimulated normal MNC, as measured by PFC or secretion of Ig into the culture medium. Isotype-specific LBL varied in their sensitivity, the secretion of IgA (1 line) and IgG (3...

journal_title：Immunobiology

authors： Wangel AG,Arvilommi H,Jokinen I

更新日期：1985-09-01 00:00:00

abstract：:Understanding the mechanisms governing the type of induced immune response after microbial invasion, could be of crucial importance for the rational design of a bacteria-based vaccine. Targeting a vaccine directly to dendritic cells (DCs), which are considered the most powerful antigen presenting cells, could be extre...

journal_title：Immunobiology

authors： Rescigno M,Rotta G,Valzasina B,Ricciardi-Castagnoli P

更新日期：2001-12-01 00:00:00

abstract：:The process of thymopoiesis is tightly regulated by a series of selection events which ensure that only functional T-lymphocytes directed against foreign antigens are exported into the periphery. The adaptive immune response largely depends on the regulation of thymocyte development, and thymocytes which fail selectio...

journal_title：Immunobiology

authors： Hutcheson J,Perlman H

更新日期：2007-01-01 00:00:00

abstract：:Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the TLRs are of considerable interest. Here we seek to determine the molecular mechanism by ...

journal_title：Immunobiology

authors： Zsengellér ZK,Gerard NP

更新日期：2020-03-01 00:00:00

abstract：:This study tested the hypothesis that CD4(+)CD25(+)CD127(low) regulatory T (Treg) cells might induce immunosuppressive properties in apoptotic neutrophils. Treg cells are recognized as a major subset of immune cells possessing potent suppressive properties directed at T effector cells. However, Treg cells have recentl...

journal_title：Immunobiology

authors： Lewkowicz N,Klink M,Mycko MP,Lewkowicz P

更新日期：2013-04-01 00:00:00

abstract：:Five mouse hybridoma cell lines producing monoclonal antibody against bovine luteinizing hormone (LH) have been established and the respective antibodies characterized by radioimmunoassay, immunofluorescence and immunoelectrophoresis. All antibodies belong to the IgG class and bind to staphylococcus protein A. Intrasp...

journal_title：Immunobiology

authors： Kofler R,Kalchschmid E,Berger P,Wick G

更新日期：1981-01-01 00:00:00

abstract：:The tumor suppressor protein P53 is strongly involved in orchestrating cellular defenses in the diverse variety of human tissues. Anomalies to lung endothelium permeability are streaming severe consequences towards human health, often associated with fatal outcomes. Ongoing investigations suggest that P53 exerts a pro...

journal_title：Immunobiology

authors： Uddin MA,Akhter MS,Siejka A,Catravas JD,Barabutis N

更新日期：2019-07-01 00:00:00

abstract：:In the present report, we describe that synthetic inhibitors of and polyclonal and monoclonal antibodies against the membrane ectoenzyme dipeptidyl peptidase IV (DP IV, CD26) inhibit the production of IL-2 and IL-6 and, concomitantly, DNA synthesis of pokeweed mitogen-stimulated peripheral blood mononuclear cells (PBM...

journal_title：Immunobiology

authors： Reinhold D,Bank U,Bühling F,Neubert K,Mattern T,Ulmer AJ,Flad HD,Ansorge S

更新日期：1993-08-01 00:00:00

abstract：:The macrophage population of the gastro-intestinal tract of the rat was studied by using a set of three monoclonal antibodies (ED1, ED2 and ED3) directed against rat macrophages, an anti-Ia monoclonal antibody and by performing an acid phosphatase reaction. The lamina propria of the whole gastro-intestinal tract compr...

journal_title：Immunobiology

authors： Sminia T,Jeurissen SH

更新日期：1986-08-01 00:00:00

abstract：:T cells play a pivotal role in controlling the immune response and have been the focus of extensive research. We studied the process of in vitro generation of antigen-specific T effector cells (Teffs) to assess the dynamics of antigen presentation and determine the best conditions for cell therapy. We used a peptidic ...

journal_title：Immunobiology

authors： de Lastic AL,Rodi M,Mouzaki A

更新日期：2016-08-01 00:00:00

abstract：:The antimicrobial peptide human β-defensin-3 (hBD-3) is produced by epidermal keratinocytes, and exhibits broad killing activity against bacteria or fungi. Prostaglandin D(2) enhances hBD-3 production in human keratinocytes by stimulating a transcription factor, activator protein-1 via chemoattractant receptor-homolog...

journal_title：Immunobiology

authors： Kanda N,Kano R,Ishikawa T,Watanabe S

更新日期：2011-04-01 00:00:00

abstract：:A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3d...

journal_title：Immunobiology

authors： Ling NR,Brown B

更新日期：1992-08-01 00:00:00

abstract：:Regulatory properties of macrophages associated with alternative activation serve to limit the exaggerated inflammatory response during pneumonia caused by Pseudomonas aeruginosa infection. Arginase-1 is an important effector of these macrophages believed to play an essential role in decreasing injury and promoting re...

journal_title：Immunobiology

authors： Haydar D,Gonzalez R,Garvy BA,Garneau-Tsodikova S,Thamban Chandrika N,Bocklage TJ,Feola DJ

更新日期：2020-11-24 00:00:00

abstract：:Although there have been numerous attempts to develop a successful vaccine against leishmaniasis, based on the clinical trial in this field, no vaccine against Leishmania in routine way can be found for globally effective vaccination in human. Amongst, first generation vaccines consisting of parasite fractions or whol...

journal_title：Immunobiology

authors： Jafari I,Heravi Shargh V,Shahryari M,Abbasi A,Jaafari MR,Khamesipour A,Badiee A

更新日期：2018-01-01 00:00:00

abstract：:Supernatants from Concanavalin A-stimulated murine spleen cells were subjected to hydrophobic interaction chromatography on phenyl-Sepharose. Macrophage cytotoxicity factor (MCF), macrophage migration inhibitory factor (MIF), T-helper cell-replacing factor (TRF) and colony-stimulating factor (CSF) were bound at high i...

journal_title：Immunobiology

authors： Hübner L,Kniep EM,Laukel H,Sorg C,Fischer H,Gassel WD,Havemann K,Kickhöfen B,Lohmann-Matthes ML,Schimpl A,Wecker E

更新日期：1980-07-01 00:00:00

abstract：:The homotypic cell aggregation of leukocytes is an unique adhesive event which is caused by cellular activation. Anti-CD44 monoclonal antibody (mAb) induces homotypic cell aggregation of hematopoietic cell lines expressing CD44, but the mechanism of homotypic cell aggregation is poorly understood. We used four mAbs ag...

journal_title：Immunobiology

authors： Cao L,Yoshino T,Nishiuchi R,Yamadori I,Akagi T

更新日期：1995-06-01 00:00:00

abstract：:The Early Growth Response Genes (EGR-1 to AT133/EGR-4) encode a family of proteins that are composed of three homologous consecutive zinc fingers of the Cys2-His2 type and different flanking sequence. Upon growth stimulation of resting cells the four EGR-genes are simultaneously transcribed. We have analyzed the expre...

journal_title：Immunobiology

authors： Skerka C,Decker EL,Zipfel PF

更新日期：1997-12-01 00:00:00

abstract：:The Hepatitis B virus (HBV) e antigen (HBeAg) is a secretory, non-structural protein, and associated with persistent infection of HBV. Previous studies indicate that HBeAg is able to regulate T cell-mediated responses, however, the interaction between HBeAg and the innate immune system is poorly understood. In this st...

journal_title：Immunobiology

authors： Leu CM,Lu YC,Peng WL,Chu HT,Hu CP

更新日期：2014-11-01 00:00:00

abstract：:Individuals infected with Strongyloides stercoralis have been reported to produce different immunoglobulins isotypes, yet few studies have evaluated their use in strongyloidiasis diagnosis. The aim of this work was to evaluate the immunoreactivity of different classes and subclasses of anti-S. stercoralis circulating ...

journal_title：Immunobiology

authors： De Souza JN,Cruz ADV,Araújo WAC,Sampaio LM,Allegretti SM,Teixeira MCA,Handali S,Galvão-Castro B,Soares NM

更新日期：2020-03-01 00:00:00

abstract：:P2X7 receptor activation is involved in a number of pro-inflammatory responses in macrophages and other immune cells. Their expression can be positively modulated with lipopolysaccharide (LPS) and TNFalpha, reinforcing their role during inflammation. We investigated the effect of substances capable of recruiting macro...

journal_title：Immunobiology

authors： Marques da Silva C,Miranda Rodrigues L,Passos da Silva Gomes A,Mantuano Barradas M,Sarmento Vieira F,Persechini PM,Coutinho-Silva R

更新日期：2008-01-01 00:00:00

abstract：:The major target organ of systemic infection with the intracellular bacterium Listeria monocytogenes is the liver, to where inflammatory leukocytes are rapidly recruited. We determined by reverse transcriptase polymerase chain reaction the early chemokine response in the liver after systemic infection of mice with lis...

journal_title：Immunobiology

authors： Barsig J,Flesch IE,Kaufmann SH

更新日期：1998-07-01 00:00:00

abstract：:Cytokines are important mediators of the effects observed after the administration of endotoxin. One of them, tumor necrosis factor, is particularly important since it plays a cardinal role in two major endotoxin activities: its antitumor effect and its capacity to induce a systemic inflammatory response syndrome. TNF...

journal_title：Immunobiology

authors： Brouckaert P,Libert C,Everaerdt B,Takahashi N,Cauwels A,Fiers W

更新日期：1993-04-01 00:00:00

abstract：:This study assessed variation in plasma levels of the complement regulatorC1 inhibitor (C1inh) in patients with age related macular degeneration (AMD) and controls. Plasma from391 AMD cases and 370 controls was assayed by rate nephelometry to determine C1inh protein levels. Protein levels were analysed for relationshi...

journal_title：Immunobiology

authors： Gibson J,Hakobyan S,Cree AJ,Collins A,Harris CL,Ennis S,Morgan BP,Lotery AJ

更新日期：2012-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common neurodegenerative disease and it poses an ever-increasing burden to an aging population. Several loci responsible for the rare, autosomal dominant form of AD have been identified (APP, PS1 and PS2), and these have facilitated the development of the amyloid cascade hypothesis...

journal_title：Immunobiology

authors： Crehan H,Holton P,Wray S,Pocock J,Guerreiro R,Hardy J

更新日期：2012-02-01 00:00:00