Abstract：
:The process of thymopoiesis is tightly regulated by a series of selection events which ensure that only functional T-lymphocytes directed against foreign antigens are exported into the periphery. The adaptive immune response largely depends on the regulation of thymocyte development, and thymocytes which fail selection in the thymus are removed by apoptosis. However, the roles of specific apoptotic proteins in early T-lymphocyte development are poorly understood. Here, we report a novel function for Bim in thymocyte development. There is an accumulation of thymocytes in Bim(-/-) mice that lack expression of CD4, CD8, CD44, and CD25 but express CD3 and TCRbeta. Further, the CD4(-)CD8(-)CD25(-)CD44(-)CD3(+)TCRbeta(+) thymocytes are smaller and do not proliferate. These data suggest that these thymocytes are mature DN thymocytes that may have down-regulated the expression of CD4 and CD8. The DN thymocyte phenotype in Bim(-/-) mice is unaffected by the additional loss of Bak or Bax and is similar to the thymic phenotype in mice lacking both Bak and Bax. These data demonstrate that Bim functions to ensure the proper homeostasis of mature thymocytes during selection and thymic export.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Hutcheson J,Perlman Hdoi
10.1016/j.imbio.2007.05.003subject
Has Abstractpub_date
2007-01-01 00:00:00pages
629-36issue
8eissn
0171-2985issn
1878-3279pii
S0171-2985(07)00069-1journal_volume
212pub_type
杂志文章相关文献
IMMUNOBIOLOGY文献大全abstract：:It is established that (1) subclinical Bordetella pertussis colonization of the nasopharynx persists in highly vaccinated populations, and (2) B. pertussis toxin is a potent adjuvant that, when co-administered with neural antigens, induces neuropathology in experimental autoimmune encephalomyelitis, the principle anim...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2015.12.008
更新日期：2016-04-01 00:00:00
abstract：:The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism. We could demo...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/S0171-2985(11)80540-1
更新日期：1995-07-01 00:00:00
abstract：:Numerous studies have shown that over-activation of microglia could cause neuroinflammation and release pro-inflammatory mediators, which could result in neurodegenerative diseases, like Parkinson's disease, Alzheimer's disease etc. Beta-naphthoflavone (BNF) has anti-oxidant and anti-inflammatory effects in borderline...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2020.151965
更新日期：2020-07-01 00:00:00
abstract：:Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2016.07.009
更新日期：2016-12-01 00:00:00
abstract：:BALB/c mice injected with 0.2 mg TNP-ovalbumin (OA) within 24 hours after birth showed reduced levels of functionally active TNP-specific B cells and, accordingly, of plaque-forming cells (PFC) after challenge with carrier-bound TNP until the age of 8 weeks. Yet, when B cells of tolerized mice were cultured in the abs...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(87)80105-5
更新日期：1987-12-01 00:00:00
abstract：:Dendritic cells (DCs) are potent antigen-presenting cells that initiate the primary immune response and whose functional properties in vivo depend on the maturation stimulus. We describe the functional properties of human monocyte-derived DCs after the maturation of immature DCs (iDCs) for 2 days with LPS (100 ng/ml),...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2012.05.003
更新日期：2013-02-01 00:00:00
abstract：:The enhancing effects of the complement system for humoral immunity have primarily focused upon the recognition of complement-bound foreign antigens by a co-receptor complex of the antigen-specific B cell receptor (BCR) and complement receptor 2 (Cr2). In vivo experiments using Cr2 gene deficient mice (which lack the ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2013.08.003
更新日期：2014-01-01 00:00:00
abstract：:Heat shock proteins (Hsps) or stress proteins are highly conserved molecules and expressed in all cell types under stressful conditions like heat, cold, hypoxia and infections. The objective of the present study was to determine the effect of dengue virus infection on relative expression of stress proteins and their r...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2008.11.010
更新日期：2009-01-01 00:00:00
abstract：:Hepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient immune responses against the virus. HBV and its antigens are believed to suppress immune responses ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2014.07.020
更新日期：2014-12-01 00:00:00
abstract：:The recent purification and cloning of T cell-derived growth factors, should lead to rapid progress in delineating their role in the generation of accessory cells and the regulation of their function. The techniques that have allowed detailed in vitro studies of the T-dependent mast cells, should be generally applicab...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/S0171-2985(84)80128-X
更新日期：1984-12-01 00:00:00
abstract：:LIF activity production by ConA-stimulated mononuclear cells was tested by measuring granulocyte migration from clotted plasma droplets placed in Microtest II plates. 90 min. incubation of MNC cultures with ConA assured a significant LIF activity in the 24 h. culture supernatants. Removal of the adherent cells after C...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(81)80097-6
更新日期：1981-01-01 00:00:00
abstract：:A modified immunoperoxidase assay on microscope slides (IPSA) was adopted as a screening procedure for hybridoma supernatants with specificity for human lymphocyte subpopulations. The method proved to be suitable for testing a large number of hybridomas with a minimum of cells and reagents. In addition, the slide-tech...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(83)80010-2
更新日期：1983-03-01 00:00:00
abstract：:We were able to characterize about 25 antigenic proteins of cultured synovial fibroblasts with apparent molecular weights of 15-230 kd by SDS-electrophoresis and immunoblotting using guinea pig antiserum. Some of these proteins were bovine-serum-derived, adsorbed onto fibroblasts from culture medium. Both rheumatoid a...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(84)80014-5
更新日期：1984-05-01 00:00:00
abstract：:Cytokines play critical roles in the pathogenesis of Behçet's disease (BD). They mediated many of the effectors and regulatory functions of immune and inflammatory responses. Many studies have linked Interleukin-6 (IL-6) and Interleukin-10 (IL-10) pathologically to BD. Thus, this study aimed to investigate the associa...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2014.03.004
更新日期：2014-08-01 00:00:00
abstract：:Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2016.11.013
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:The soluble form of the haptoglobin-hemoglobin (Hp-Hb) scavenger receptor (sCD163) is a specific plasma/serum marker for macrophage activity. Here, we have characterized molecular forms in serum and investigated a role of sCD163 as a binder of Hp-Hb complexes. METHODS:The sCD163 species in serum (from 50 he...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2009.05.003
更新日期：2010-05-01 00:00:00
abstract：:The concept of using mesenchymal stem cells (MSCs) in bone repair has progressively evolved, and the goal of cell-mediated therapy is to prolong the natural physiological abilities of healing, or substitute them, when these are lacking, failing, or progressing too slowly. The future application of MSCs in human therap...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2008.07.030
更新日期：2009-01-01 00:00:00
abstract：:This paper describes the characteristics of T suppressor inducer (Ts ind) cells which can interact with T suppressor effector (Ts eff) cells and thereby can account for suppression of delayed-type hypersensitivity (DTH) to alloantigens. Adoptive transfer of spleen cells from mice intravenously (i.v.) injected with all...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/s0171-2985(89)80007-5
更新日期：1989-03-01 00:00:00
abstract：:The anticonvulsant drug phenytoin, in less than cytotoxic concentrations, caused significant reductions in Ig secretion by unstimulated or EBV-stimulated normal MNC, as measured by PFC or secretion of Ig into the culture medium. Isotype-specific LBL varied in their sensitivity, the secretion of IgA (1 line) and IgG (3...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(85)80094-2
更新日期：1985-09-01 00:00:00
abstract：:Most malignant tumors contain so-called tumor-associated macrophages (TAM) as a major component of their leukocytic infiltrate. To investigate the impact of the tumor microenvironment on activation and differentiation of macrophages, we established a 3-dimensional model system by culturing human monocytes within multi...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1078/0171-2985-00246
更新日期：2003-01-01 00:00:00
abstract：:The majority of B lymphocytes, virgin T lymphocytes and a subpopulation of memory T cells express the addressin, L-selectin. Natural killer (NK) cells in rodents and humans also express L-selectin. We have shown that a similar proportion (40%) of NK cells in mouse spleen also express the integrin, CD18Mac-1, and moreo...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1078/0171-2985-00220
更新日期：2003-01-01 00:00:00
abstract：:Human urinary colony-stimulating factor (CSF-HU) has been partially purified using five purification procedures (preparation II) for clinical use. In phase I study, six healthy volunteers were injected with preparation II of CSF-HU by a single intravenous droplet infusion. Two volunteers received 4 X 10(6) units (U), ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(86)80100-0
更新日期：1986-09-01 00:00:00
abstract：:In contrast to murine spleen M phi, resident peritoneal M phi from health mice express very little Forssman glycolipid antigen (Fo). The following experiments suggest that Fo expression by peritoneal M phi may be associated with inflammation. Balb/c and CBA/J mice were given inflammatory stimuli by i.p. injection of l...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/s0171-2985(11)80302-5
更新日期：1990-06-01 00:00:00
abstract：:This is the first application of flow cytometry for the detection of lamina propria plasma cells and their intracellular immunoglobulins in patients with inflammatory bowel disease compared to healthy controls. The study has been focused on the distribution of IgA, IgG, IgM and the four IgG subclasses. Plasma cells we...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1078/0171-2985-00203
更新日期：2002-12-01 00:00:00
abstract：:The inability of spontaneous and some laboratory-induced tumors to stimulate the immune system has continuously raised the question of the validity of using immunological maneuvers in order to control tumor growth. In this project we suggest that a tumor which is nonimmunogenic still has an immunogenic potential that ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(82)80101-0
更新日期：1982-10-01 00:00:00
abstract：:Living organisms have strong defense mechanisms against invading microorganisms as survival strategies. One of the defense mechanisms is the complement system, composed of more than 30 serum and cell surface components. This system collaborates in recognition and elimination of pathogens as a part of both the innate a...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2006.01.003
更新日期：2006-01-01 00:00:00
abstract：:The defective antigen presenting ability of antigen presenting cells (APCs) modulates host cytokines and co-stimulatory signals that may lead to severity of leprosy. In the present study, we sought to evaluate the phenotypic features of APCs along with whether DC SIGN (DC-specific intercellular adhesion molecule-grabb...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2013.05.004
更新日期：2013-12-01 00:00:00
abstract：:The alarming rise of obesity and type 2 diabetes (T2D) has put a tremendous strain on global healthcare systems. Over the past decade extensive research has focused on the role of macrophages as key mediators of inflammation in T2D. The inflammatory environment in the obese adipose tissue and pancreatic β-cell islets ...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2016.08.011
更新日期：2017-10-01 00:00:00
abstract：:Macrophages are major effector cells of the innate immune system, and appropriate regulation of macrophage function requires the integration of multiple signalling inputs derived from the recognition of host factors (e.g. interferon-gamma/IFNgamma) and pathogen products (e.g. toll-like receptor/TLR agonists). The prof...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2006.05.007
更新日期：2006-01-01 00:00:00
abstract：:According to present concepts, innate immunity plays an important role in tumor surveillance and immune modulation. The state of NK cells depends on the balance between inhibitory and activating signals from corresponding receptors. As one of the activating receptors, NKG2D recognises some self ligands such as MICA/B ...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2004.04.008
更新日期：2004-01-01 00:00:00
