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Signal integration between IFNgamma and TLR signalling pathways in macrophages.

Abstract：

:Macrophages are major effector cells of the innate immune system, and appropriate regulation of macrophage function requires the integration of multiple signalling inputs derived from the recognition of host factors (e.g. interferon-gamma/IFNgamma) and pathogen products (e.g. toll-like receptor/TLR agonists). The profound effects of IFNgamma pre-treatment ("priming") on TLR-induced macrophage activation have long been recognised, but many of the mechanisms underlying the priming phenotype have only recently been identified. This review summarises the known mechanisms of integration between the IFNgamma and TLR signalling pathways. Synergy occurs at multiple levels, ranging from signal recognition to convergence of signals at the promoters of target genes. In particular, the cross-talk between the IFNgamma, and LPS and CpG DNA signalling pathways is discussed.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Schroder K,Sweet MJ,Hume DA

doi

10.1016/j.imbio.2006.05.007

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

511-24

issue

6-8

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(06)00064-7

journal_volume

211

pub_type

杂志文章,评审

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