Multiorgan failure and antiphospholipid antibodies: the catastrophic antiphospholipid (Asherson's) syndrome.


:A review of 250 patients with the catastrophic antiphospholipid (Asherson's) syndrome (CAPS) taken from the web site organized by the Europhospholipid Group ( is presented in this paper. A short historical overview of the antiphospholipid syndrome (APS) is followed by a description of the "triggering" factors, associated autoimmune diseases, clinical presentation, presumed pathogenesis, prognosis, mode of death and suggested therapies. Triggering factors are present in approximately 50% of patients and consist predominantly of infections, trauma, including minor surgical procedures such as biopsies, obstetric-related multiorgan failure and malignancy-associated CAPS. The patients present mainly with multiorgan failure resulting from predominantly small vessel occlusions affecting mainly intra-abdominal organs such as bowel, liver, pancreas, and adrenals, although large vessel occlusions do occur and comprise mainly deep vein thromboses (DVT) of the veins of the lower limbs and arterial occlusions causing strokes and peripheral gangrene. They do not however dominate the clinical picture. The condition differs considerably from the simple/classic APS in several respects, viz. the rapid development of multiorgan failure following the above-mentioned identifiable precipitating factors, the involvement of unusual organs such as bowel, reproductive organs, and bone marrow, complicating features of disseminated intravascular coagulation in 20% of cases, the acute (adult) respiratory distress syndrome (ARDS) in one third of patients, and severe thrombocytopenia; these not being encountered in the simple/classic APS. Treatment consisting of regular and repeated plasma exchanges using fresh frozen plasma, and IV immunoglobulins in addition to parenteral steroids and anticoagulation are necessary to improve the survival in a condition where the mortality is still of the order of 50%. Treatment may have to be continued for several weeks. Parenteral antibiotics may be indicated where an underlying infection is suspected. Antifungal therapy may also be indicated with prolonged treatment and the use of the monoclonal anti-CD20 molecule, Rituximab, has proven useful in those patients where thrombocytopenia poses a major risk of hemorrhage.






Asherson RA




Has Abstract


2005-01-01 00:00:00














  • Detection of cytokine receptors by high-sensitivity immunofluorescence/flow cytometry.

    abstract::Cytokines have profound effects on cells, and act through receptors which need only be at low concentrations (around 100 copies per cell) to transmit activation signals. The detection of such low concentrations is possible using monoclonal antibodies and fluorescence/flow cytometry, but only by using specialized techn...


    pub_type: 杂志文章,评审


    authors: Zola H,Flego L,Sheldon A

    更新日期:1992-08-01 00:00:00

  • Expression of transcription factor genes after influenza A virus infection.

    abstract::Infection of human monocytes with influenza A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis. The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorl...


    pub_type: 杂志文章


    authors: Bussfeld D,Bacher M,Moritz A,Gemsa D,Sprenger H

    更新日期:1997-12-01 00:00:00

  • Hyperreactivity of adult BALB/c mice tolerized at birth with TNP-ovalbumin.

    abstract::BALB/c mice injected with 0.2 mg TNP-ovalbumin (OA) within 24 hours after birth showed reduced levels of functionally active TNP-specific B cells and, accordingly, of plaque-forming cells (PFC) after challenge with carrier-bound TNP until the age of 8 weeks. Yet, when B cells of tolerized mice were cultured in the abs...


    pub_type: 杂志文章


    authors: Zöller M,Andrighetto G

    更新日期:1987-12-01 00:00:00

  • Carboxypeptidase N-deficient mice present with polymorphic disease phenotypes on induction of experimental autoimmune encephalomyelitis.

    abstract::Carboxypeptidase N (CPN) is a member of the carboxypeptidase family of enzymes that cleave carboxy-terminal lysine and arginine residues from a large number of biologically active peptides and proteins. These enzymes are best known for their roles in modulating the activity of kinins, complement anaphylatoxins and coa...


    pub_type: 杂志文章


    authors: Hu X,Wetsel RA,Ramos TN,Mueller-Ortiz SL,Schoeb TR,Barnum SR

    更新日期:2014-02-01 00:00:00

  • Interferon regulatory factor 3 plays a role in macrophage responses to interferon-γ.

    abstract::IFN-γ produced during viral infections activates the IFN-γ receptor (IFNGR) complex for STAT1 transcriptional activity leading to expression of Interferon Regulatory Factors (IRF). Simultaneous activation of TBK/IKKε via TLR3 during viral infections activates the transcription factor IRF3. Together these transcription...


    pub_type: 杂志文章


    authors: Guinn ZP,Petro TM

    更新日期:2019-07-01 00:00:00

  • Macrophages and hepatocytic cells as chemokine producers in murine listeriosis.

    abstract::The major target organ of systemic infection with the intracellular bacterium Listeria monocytogenes is the liver, to where inflammatory leukocytes are rapidly recruited. We determined by reverse transcriptase polymerase chain reaction the early chemokine response in the liver after systemic infection of mice with lis...


    pub_type: 杂志文章


    authors: Barsig J,Flesch IE,Kaufmann SH

    更新日期:1998-07-01 00:00:00

  • Tumor necrosis factor, its receptors and the connection with interleukin 1 and interleukin 6.

    abstract::Cytokines are important mediators of the effects observed after the administration of endotoxin. One of them, tumor necrosis factor, is particularly important since it plays a cardinal role in two major endotoxin activities: its antitumor effect and its capacity to induce a systemic inflammatory response syndrome. TNF...


    pub_type: 杂志文章,评审


    authors: Brouckaert P,Libert C,Everaerdt B,Takahashi N,Cauwels A,Fiers W

    更新日期:1993-04-01 00:00:00

  • Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease.

    abstract::α-Synuclein plays a crucial role in Parkinson's disease and dementias defined as synucleinopathies. α-Synuclein is expressed in hematopoietic and immune cells, but its functions in hematopoiesis and immune responses are unknown. We utilized α-synuclein(-/-) (KO) mice to investigate its role in hematopoiesis and B cell...


    pub_type: 杂志文章


    authors: Xiao W,Shameli A,Harding CV,Meyerson HJ,Maitta RW

    更新日期:2014-11-01 00:00:00

  • Trophoblast cell influence on peripheral blood natural killer cell proliferation and phenotype in non-pregnant women and women in early pregnancy.

    abstract::Natural killer (NK) cells are the main population of leukocytes in decidua during the first trimester of pregnancy. NK cells can have contact with trophoblast cells during pregnancy, which raises the possibility of mutual influence. This research aimed to evaluate the proliferation and phenotype of peripheral blood NK...


    pub_type: 杂志文章


    authors: Mikhailova VA,Kudryavtsev IV,Serebryakova MK,Milyutina YP,Demidova ES,Panina AN,Bazhenov DO,Belikova ME,Selkov SA,Sokolov DI

    更新日期:2020-05-01 00:00:00

  • PD-1 function in apoptosis of T lymphocytes in canine visceral leishmaniasis.

    abstract::Dogs infected with Leishmania infantum have a reduced number of T lymphocytes. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family that is expressed by immune cells, and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces the deactivation or apoptosis of T cells. This study aimed to evaluate the expres...


    pub_type: 杂志文章


    authors: Chiku VM,Silva KL,de Almeida BF,Venturin GL,Leal AA,de Martini CC,de Rezende Eugênio F,Dos Santos PS,de Lima VM

    更新日期:2016-08-01 00:00:00

  • Functional properties of a novel neutrophil chemotactic factor derived from human monocytes.

    abstract::Neutrophilic granulocytes (PMN) are attracted to sites of inflammation by chemotactic factors, the most potent of which are the complement split product C5a, the leukotriene B4 and the bacterial chemotactic factor-related tripeptide formyl-methionyl-leucyl-phenylalanine (FMLP). In addition to inducing directed migrati...


    pub_type: 杂志文章


    authors: Kownatzki E,Uhrich S,Grüninger G

    更新日期:1988-09-01 00:00:00

  • The acquisition of anti-influenza virus activity by macrophages.

    abstract::Exposure of resident peritoneal macrophages or thioglycollate-induced macrophages (TG-Mø) to influenza or Sendai virus-infected spleen cell culture supernatants (MAS) resulted in macrophage activation. When normal resident macrophages were used as effector cells, both infected P815 and L929 cells were lysed in the pre...


    pub_type: 杂志文章


    authors: Mak NK,Ada GL

    更新日期:1984-05-01 00:00:00

  • Calcium signalling by the high affinity macrophage Fc gamma receptor requires the cytosolic domain.

    abstract::Hematopoietic cells express multiple receptors which bind the Fc domain of IgG. We utilized transfection of COS-1 cells, a cell line which lacks endogenous Fc receptors, to study the expression and function of Fc gamma RI, the high affinity Fc gamma receptor in the absence of other Fc gamma receptors. Fc gamma RI was ...


    pub_type: 杂志文章


    authors: Indik Z,Chien P,Levinson AI,Schreiber AD

    更新日期:1992-08-01 00:00:00

  • Effect of ovarian hormones on periodical changes in immune resistance associated with estrous cycle in the beagle bitch.

    abstract::In bitches, the onset of pyometra, an infection of the uterus, characteristically occurs in the first half of the diestrous stage in the estrous cycle, in which the blood concentration of progesterone peaks and that of estradiol-17beta is lowest. To investigate the immunological mechanisms governing stage-specific ons...


    pub_type: 杂志文章


    authors: Sugiura K,Nishikawa M,Ishiguro K,Tajima T,Inaba M,Torii R,Hatoya S,Wijewardana V,Kumagai D,Tamada H,Sawada T,Ikehara S,Inaba T

    更新日期:2004-01-01 00:00:00

  • Role of arginine metabolism in immunity and immunopathology.

    abstract::A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of ...


    pub_type: 杂志文章,评审


    authors: Peranzoni E,Marigo I,Dolcetti L,Ugel S,Sonda N,Taschin E,Mantelli B,Bronte V,Zanovello P

    更新日期:2007-01-01 00:00:00

  • Neutrophil--CD4+CD25+ T regulatory cell interactions: a possible new mechanism of infectious tolerance.

    abstract::This study tested the hypothesis that CD4(+)CD25(+)CD127(low) regulatory T (Treg) cells might induce immunosuppressive properties in apoptotic neutrophils. Treg cells are recognized as a major subset of immune cells possessing potent suppressive properties directed at T effector cells. However, Treg cells have recentl...


    pub_type: 临床试验,杂志文章


    authors: Lewkowicz N,Klink M,Mycko MP,Lewkowicz P

    更新日期:2013-04-01 00:00:00

  • Chemical characterization of macrophage cytotoxicity factor, macrophage migration inhibitory factor, T-helper cell-replacing factor and colony-stimulating factor from culture supernatants of concanavalin A-stimulated murine spleen cells.

    abstract::Supernatants from Concanavalin A-stimulated murine spleen cells were subjected to hydrophobic interaction chromatography on phenyl-Sepharose. Macrophage cytotoxicity factor (MCF), macrophage migration inhibitory factor (MIF), T-helper cell-replacing factor (TRF) and colony-stimulating factor (CSF) were bound at high i...


    pub_type: 杂志文章


    authors: Hübner L,Kniep EM,Laukel H,Sorg C,Fischer H,Gassel WD,Havemann K,Kickhöfen B,Lohmann-Matthes ML,Schimpl A,Wecker E

    更新日期:1980-07-01 00:00:00

  • IL-33/ST2 axis controls Th2/IL-31 and Th17 immune response in allergic airway diseases.

    abstract::IL-33 targeting ST2 receptor (T1/ST2), expressed on Th2 cell surface, regulates the production of cytokines like IL-17A and IL-31. We studied the role of IL-33/ST2 axis in IL-31 and IL-17A production in patients with allergic rhinitis (AR) and with concomitant allergic asthma and rhinitis (AAR). 20 healthy control sub...


    pub_type: 杂志文章


    authors: Vocca L,Di Sano C,Uasuf CG,Sala A,Riccobono L,Gangemi S,Albano GD,Bonanno A,Gagliardo R,Profita M

    更新日期:2015-08-01 00:00:00

  • The immunosuppressive activities of different cyclosporins are correlated to inhibition of the early membrane phospholipid metabolism in activated lymphocytes.

    abstract::Recently, it could be shown that Cyclosporin A (CsA) inhibited the activation of T and B lymphocytes by interfering with an early step of the activation, namely the stimulation of the plasma membrane-bound lysophosphatide acyltransferase. In this report, we compared three CsA-derivatives, Dihydro-Cyclosporin C (Dihydr...


    pub_type: 杂志文章


    authors: Kroggel R,Goppelt-Strübe M,Martin M,Resch K

    更新日期:1987-09-01 00:00:00

  • Long term iNOS expression in thoracic lymph nodes of silicotic rats.

    abstract::Beside the lung, thoracic lymph nodes are most affected during silicosis. The mechanisms leading to enlargement of the lymph nodes and partial activation of lymph node cells are still unclear. The present study demonstrates an increase in iNOS mRNA expression in the lung draining lymph nodes of rats at 1, 2, and 8 mon...


    pub_type: 杂志文章


    authors: Friedetzky A,Grau V,Wieckenberg M,Lewen A,Gemsa D,Garn H

    更新日期:2002-07-01 00:00:00

  • Maturation of human iDCs by IL-18 plus PGE2, but not by each stimulus alone, induced migration toward CCL21 and the secretion of IL-12 and IFN-γ.

    abstract::Dendritic cells (DCs) are potent antigen-presenting cells that initiate the primary immune response and whose functional properties in vivo depend on the maturation stimulus. We describe the functional properties of human monocyte-derived DCs after the maturation of immature DCs (iDCs) for 2 days with LPS (100 ng/ml),...


    pub_type: 杂志文章


    authors: da Silva I,Gomes GG,Menezes CC,Palma PV,Orellana MD,Covas DT,Chammas R,Greene LJ

    更新日期:2013-02-01 00:00:00

  • The pivotal role of p38 and NF-kappaB signal pathways in the maturation of human monocyte-derived dendritic cells stimulated by streptococcal agent OK-432.

    abstract::OK-432, a streptococcal preparation, has been shown as an effective activator to induce human monocyte-derived dendritic cells maturation. During this process, the activation of Toll-like receptor 4 plays an important role. However, the signaling pathway involved in has not been fully understood. In the present study,...


    pub_type: 杂志文章


    authors: Pan K,Wang H,Liu WL,Zhang HK,Zhou J,Li JJ,Weng DS,Huang W,Sun JC,Liang XT,Xia JC

    更新日期:2009-01-01 00:00:00

  • Autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline caspase-10 (CASP10) variation.

    abstract::Autoimmune lymphoproliferative syndrome (ALPS) is a primary immunodeficiency caused by impaired Fas/FasL-mediated apoptosis of lymphocytes and is characterized by chronic nonmalignant or benign lymphoproliferation, autoimmune manifestations and expansion of double negative (DN) T-cells (TCRαβ+CD4-CD8-). Most cases of ...


    pub_type: 杂志文章


    authors: Martínez-Feito A,Melero J,Mora-Díaz S,Rodríguez-Vigil C,Elduayen R,González-Granado LI,Pérez-Méndez D,Sánchez-Zapardiel E,Ruiz-García R,Menchén M,Díaz-Madroñero J,Paz-Artal E,Del Orbe-Barreto R,Riñón M,Allende LM

    更新日期:2016-01-01 00:00:00

  • Lewis lung carcinoma cells enhance the synthesis of C3 and are opsonized by C3 secreted from murine macrophages.

    abstract::We investigated the effect of Lewis Lung carcinoma cells on the production of C3 by murine macrophages and examined the capacity of secreted C3 to opsonize Lewis Lung carcinoma cells. C3 released in culture from macrophages obtained from tumor-bearing C57Bl/6 mice as well as from normal macrophages exposed to Lewis Lu...


    pub_type: 杂志文章


    authors: Lipari M,Di Renzo L,Zicari A,Schulz TF,Magliocca A,Mardente S,Dierich MP,Pontieri GM

    更新日期:1988-07-01 00:00:00

  • Effect of spleen exposure to ultrasound on cellular and antibody-mediated immune reactions in man.

    abstract::Spleen exposure to ultrasound has been reported to influence antibody response to sheep red blood cell injection in mice (decreased hemagglutination and hemolytic titers and IgM, IgG2a and IgG2b levels and elevated IgG1 levels). In a controlled clinical trial, we investigated the possible immunosuppressive side-effect...


    pub_type: 临床试验,杂志文章


    authors: Berthold F,Berthold R,Matter I,Reither M,Rother U,Skvaril F,Willems WR

    更新日期:1982-01-01 00:00:00

  • Engagement of CD147 molecule-induced cell aggregation through the activation of protein kinases and reorganization of the cytoskeleton.

    abstract::CD147 is a broadly expressed cell surface molecule of the immunoglobulin superfamily whose expression is up-regulated upon T cell activation. Engagement of CD147 by CD147 monoclonal antibodies (mAbs) has been shown to induce homotypic aggregation of U937 cells. To study intracellular signal transduction induced by the...


    pub_type: 杂志文章


    authors: Khunkeawla P,Moonsom S,Staffler G,Kongtawelert P,Kasinrerk W

    更新日期:2001-05-01 00:00:00

  • The role of nucleotide-binding oligomerization domain 1 during cytokine production by macrophages in response to Mycobacterium tuberculosis infection.

    abstract::Tuberculosis due to Mycobacterium tuberculosis infection is a leading cause of death worldwide. Recognition of this pathogen is crucial for the activation of innate and adaptive immune responses. Nucleotide-binding oligomerization domain (Nod)1 and Nod2 are cytoplasmic receptors that can detect unique muropeptides of ...


    pub_type: 杂志文章


    authors: Lee JY,Hwang EH,Kim DJ,Oh SM,Lee KB,Shin SJ,Park JH

    更新日期:2016-01-01 00:00:00

  • Characterization and biological effects of recombinant human erythropoietin.

    abstract::Human recombinant erythropoietin (rHuEPO) has been purified to apparent homogeneity and compared to purified human urinary erythropoietin (EPO). Both the purified natural and recombinant EPO preparations were characterized in a competition radioimmunoassay (RIA), the exhypoxic polycythemic mouse bioassay, in vitro tis...


    pub_type: 杂志文章


    authors: Egrie JC,Strickland TW,Lane J,Aoki K,Cohen AM,Smalling R,Trail G,Lin FK,Browne JK,Hines DK

    更新日期:1986-09-01 00:00:00

  • Antibody responsiveness during immunization and challenge of genetically modified antibody responder mice with murine hepatitis virus 3.

    abstract::The aim of this study was to evaluate some immunological patterns involved in natural and acquired resistance against MHV3 using the original model of genetically modified lines of mice selected for high (HIII) and low (LIII) antibody responsiveness. As previously shown, a lower pre-existing anti-MHV antibody level wa...


    pub_type: 杂志文章


    authors: Vassão RC,Consales CA,Sant'Anna OA,Pereira CA

    更新日期:2003-01-01 00:00:00

  • RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters.

    abstract::The leukocyte integrins CD11a/CD18 (LFA-1, alphaLbeta2) and CD49d (VLA-4, alpha4beta1, alpha4beta7) mediate leukocyte transendothelial migration during immune and inflammatory responses and provides co-stimulatory signals for the activation of T lymphocytes. Our previous studies demonstrate that the CD11a gene promote...


    pub_type: 杂志文章


    authors: Domínguez-Soto A,Relloso M,Vega MA,Corbí AL,Puig-Kröger A

    更新日期:2005-01-01 00:00:00