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Tumor transfected with CCL21 enhanced reactivity and apoptosis resistance of human monocyte-derived dendritic cells.

Abstract：

:Chemokine CCL21 can effectively attract CCR7(+) dendritic cells (DCs), however its role in this event is poorly understood. In this report, we investigated the effect of exogenous CCL21 expressed in breast cancer MCF-7 on human monocyte-derived DCs. CCL21-transfected MCF-7 stimulation prompted DC functions: migration, antigen-uptake and presentation. The stimulated DCs facilitated Th1 type cytokines production, perforin-forming CD8(+) T cell transformation and final T cell-associated clearance of MCF-7. Moreover, the MCF-7-resourced CCL21 protected DCs from apoptosis significantly, involving up-regulations of Bcl-2 expression and NF-kappaB activity, and reduction of caspase-3. This study provides evidence that tumor-derived CCL21 increases the presentation and apoptosis resistance of DCs, suggesting such a mechanism may be useful for the improvement of tumor cell immunogenicity and anti-tumor response.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Wu S,Xing W,Peng J,Yuan X,Zhao X,Lei P,Li W,Wang M,Zhu H,Huang B,Huang L,Shen G

doi

10.1016/j.imbio.2007.10.003

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

417-26

issue

5

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(07)00124-6

journal_volume

213

pub_type

杂志文章

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