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The zwitterionic type I Streptococcus pneumoniae polysaccharide does not induce memory B cell formation in humans.

Abstract：

:In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to Sp1-induced T cell proliferation, a hallmark of thymus-dependent immune responses. We used peripheral blood mononuclear cells obtained from adults enrolled in a randomised clinical trial to investigate memory B cell responses following immunisation with the 23-valent pneumococcal plain polysaccharide vaccine. Administration of this serotype 1 containing vaccine resulted in the depletion of serotype 1 antigen-specific pre-existing memory B cells compared to baseline. This finding indicates that this ZPS is not processed by a classical TD mechanism within the MHC-II pathway.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Trück J,Lazarus R,Clutterbuck EA,Bowman J,Kibwana E,Bateman EA,Pollard AJ

doi

10.1016/j.imbio.2012.05.008

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

368-72

issue

3

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(12)00111-8

journal_volume

218

pub_type

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