Antiphospholipid antibodies in pediatric patients with prolonged activated partial thromboplastin time during infection.

abstract：:Hematopoietic cells express multiple receptors which bind the Fc domain of IgG. We utilized transfection of COS-1 cells, a cell line which lacks endogenous Fc receptors, to study the expression and function of Fc gamma RI, the high affinity Fc gamma receptor in the absence of other Fc gamma receptors. Fc gamma RI was ...

journal_title：Immunobiology

authors： Indik Z,Chien P,Levinson AI,Schreiber AD

更新日期：1992-08-01 00:00:00

abstract：:The expansion of effector T cells is tightly controlled by transcription factors like nuclear factor of activated T cells (NFAT) family members that mediate early intracellular responses to T cell receptor-mediated signals. In this study we show that, after allergen challenge, NFATc2((-/-)) mice had augmented number o...

journal_title：Immunobiology

authors： Karwot R,Übel C,Bopp T,Schmitt E,Finotto S

更新日期：2012-09-01 00:00:00

abstract：:Human recombinant erythropoietin (rHuEPO) has been purified to apparent homogeneity and compared to purified human urinary erythropoietin (EPO). Both the purified natural and recombinant EPO preparations were characterized in a competition radioimmunoassay (RIA), the exhypoxic polycythemic mouse bioassay, in vitro tis...

journal_title：Immunobiology

authors： Egrie JC,Strickland TW,Lane J,Aoki K,Cohen AM,Smalling R,Trail G,Lin FK,Browne JK,Hines DK

更新日期：1986-09-01 00:00:00

abstract：:Infection of human monocytes with influenza A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis. The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorl...

journal_title：Immunobiology

authors： Bussfeld D,Bacher M,Moritz A,Gemsa D,Sprenger H

更新日期：1997-12-01 00:00:00

abstract：:OK-432, a streptococcal preparation, has been shown as an effective activator to induce human monocyte-derived dendritic cells maturation. During this process, the activation of Toll-like receptor 4 plays an important role. However, the signaling pathway involved in has not been fully understood. In the present study,...

journal_title：Immunobiology

authors： Pan K,Wang H,Liu WL,Zhang HK,Zhou J,Li JJ,Weng DS,Huang W,Sun JC,Liang XT,Xia JC

更新日期：2009-01-01 00:00:00

abstract：:Ficolins and mannan-binding lectin recognize pathogen-associated molecular patterns and initiate the lectin pathway of complement activation via the associated serine proteases. In contrast to human ficolins and mouse ficolin-A, mouse ficolin-B has been considered incapable of complement activation. Dose-dependent bin...

journal_title：Immunobiology

authors： Hunold K,Weber-Steffens D,Runza VL,Jensenius JC,Männel DN

更新日期：2012-10-01 00:00:00

abstract：:Dengue fever, a public health problem in Brazil, may present severe clinical manifestations as result of an increased vascular permeability and coagulation disorders. T cell activation is a critical event for an effective immune response against infection, including the production of cytokines. We aim to reveal mechan...

journal_title：Immunobiology

authors： Torrentes-Carvalho A,Marinho CF,de Oliveira-Pinto LM,de Oliveira DB,Damasco PV,Cunha RV,de Souza LJ,de Azeredo EL,Kubelka CF

更新日期：2014-05-01 00:00:00

abstract：:Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...

journal_title：Immunobiology

authors： De Schryver M,Leemans A,Pintelon I,Cappoen D,Maes L,Caljon G,Cos P,Delputte PL

更新日期：2017-06-01 00:00:00

abstract：:Memory T cells producing interferon (IFN)γ and expressing very late antigen-1 (VLA-1) integrin collagen receptors are found in carotid atherosclerotic plaques, suggesting their involvement in coronary artery disease (CAD) as well. To determine the role of VLA-1+ T cells in CAD percent of CD3+ T cells binding monoclona...

journal_title：Immunobiology

authors： Asman A,Chouraqui P,Marcu-Malina V,Matetzky S,Segev A,Fefer P,Agranat O,Koltakov A,Hod H,Livneh A,Bank I

更新日期：2014-04-01 00:00:00

abstract：:Porphyromonas gingivalis 381 lipid A induced strong mitogenic response in splenic B cells separated from LPS-non-responsive C3H/HeJ mice as well as LPS-responsive C3H/HeN mice, by using a magnetic cell sorting system. The lipid A also exhibited mitogenic activity in splenic T cells. P. gingivalis lipid A induced lower...

journal_title：Immunobiology

authors： Ogawa T,Shimauchi H,Uchida H,Mori Y

更新日期：1996-01-01 00:00:00

abstract：:Chitin and β-glucan are conserved throughout evolution in the fungal cell wall and are the most common polysaccharides in fungal species. Together, these two polysaccharides form a structural scaffold that is essential for the survival of the fungus. In the present study, we demonstrated that Aspergillus fumigatus alk...

journal_title：Immunobiology

authors： Dubey LK,Moeller JB,Schlosser A,Sorensen GL,Holmskov U

更新日期：2014-03-01 00:00:00

abstract：:Splenic B cells of BALB/c mice were stimulated in vitro either with lipopolysaccharide (LPS), dextran sulphate (DxS), or with both LPS and DxS. The absolute frequency of B cells that differentiate into clones of immunoglobulin (Ig)-secreting cells upon activation with these mitogens was determined by means of limiting...

journal_title：Immunobiology

authors： Bos NA,Meeuwsen CG,de Visser H,Benner R

更新日期：1988-02-01 00:00:00

abstract：:Glypican-3 (GPC3) is an attractive target for chimeric antigen receptor (CAR)-T cell therapy, as it is overexpressed in most hepatocellular carcinoma (HCC) tissues but shows restricted expression in healthy adult tissues. Herein, we generated GPC3-specific CAR-T cells for HCC therapy by electroporation with plasmid DN...

journal_title：Immunobiology

authors： Wang P,Qin W,Liu T,Jiang D,Cui L,Liu X,Fang Y,Tang X,Jin H,Qian Q

更新日期：2020-01-01 00:00:00

abstract：:Regulatory T cells that express CD39 (CD39+ Treg) exhibit specific immunomodulatory properties. Ectonucleotidase CD39 hydrolyses ATP and ADP. ATP is a ligand of the P2X7 receptor and induces the shedding of CD62L and apoptosis. However, the role of ATP in CD39+ Treg cells has not been defined. Furthermore, NAD can act...

journal_title：Immunobiology

authors： Cortés-Garcia JD,López-López C,Cortez-Espinosa N,García-Hernández MH,Guzmán-Flores JM,Layseca-Espinosa E,Portales-Cervantes L,Portales-Pérez DP

更新日期：2016-01-01 00:00:00

abstract：CONTEXT:The PDS gene (SLC26A4) is responsible for Pendred syndrome (PS). Genetic analysis of PDS using Tunisian samples showed evidence for linkage and association with autoimmune thyroid diseases (AITD) emergence. In addition, the PDS gene product, pendrin, was recently identified as a novel autoantigen in Graves' dis...

journal_title：Immunobiology

authors： Belguith-Maalej S,Rebuffat SA,Charfeddine I,Mnif M,Nadir RF,Abid M,Ghorbel A,Peraldi-Roux S,Ayadi H,Hadj-Kacem H

更新日期：2011-05-01 00:00:00

abstract：:This study investigated the actin scavenger function of the vitamin D binding protein (DBP) in vivo using DBP null (-/-) mice. Intravenous injection of G-actin into wild-type (DBP+/+) and DBP-/- mice showed that contrary to expectations, DBP+/+ mice developed more severe acute lung inflammation. Inflammation was restr...

journal_title：Immunobiology

authors： Ge L,Trujillo G,Miller EJ,Kew RR

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:NK cells as a part of innate immune system, are controlled by a set of activating and inhibitory KIR receptors (aKIR, iKIR) which are implicated in tumor microenvironment immunity through a variety of activating and inhibitory immune signals. KIRs are multi gene family receptors that differ in the number and...

journal_title：Immunobiology

authors： Barani S,Taghipour M,Ghaderi A

更新日期：2020-03-01 00:00:00

abstract：:Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activat...

journal_title：Immunobiology

authors： Nymo S,Niyonzima N,Espevik T,Mollnes TE

更新日期：2014-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease characterized by progressive airflow limitation, chronic respiratory symptoms and frequent exacerbations. There is an unmet need to identify novel therapeutic alternatives beside bronchodilators that prevent disease progression. Levels of both...

journal_title：Immunobiology

authors： Douaoui S,Djidjik R,Boubakeur M,Ghernaout M,Touil-Boukoffa C,Oumouna M,Derrar F,Amrani Y

更新日期：2020-05-01 00:00:00

abstract：:The century-old tuberculosis vaccine BCG has been the focus of renewed interest due to its well-documented ability to protect against various non-TB pathogens. Much of these broad spectrum protective effects are attributed to trained immunity, the epigenetic and metabolic reprogramming of innate immune cells. As BCG v...

journal_title：Immunobiology

authors： Moulson AJ,Av-Gay Y

更新日期：2020-12-24 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is a primary immunodeficiency caused by impaired Fas/FasL-mediated apoptosis of lymphocytes and is characterized by chronic nonmalignant or benign lymphoproliferation, autoimmune manifestations and expansion of double negative (DN) T-cells (TCRαβ+CD4-CD8-). Most cases of ...

journal_title：Immunobiology

authors： Martínez-Feito A,Melero J,Mora-Díaz S,Rodríguez-Vigil C,Elduayen R,González-Granado LI,Pérez-Méndez D,Sánchez-Zapardiel E,Ruiz-García R,Menchén M,Díaz-Madroñero J,Paz-Artal E,Del Orbe-Barreto R,Riñón M,Allende LM

更新日期：2016-01-01 00:00:00

abstract：:Cytokines are important mediators of the effects observed after the administration of endotoxin. One of them, tumor necrosis factor, is particularly important since it plays a cardinal role in two major endotoxin activities: its antitumor effect and its capacity to induce a systemic inflammatory response syndrome. TNF...

journal_title：Immunobiology

authors： Brouckaert P,Libert C,Everaerdt B,Takahashi N,Cauwels A,Fiers W

更新日期：1993-04-01 00:00:00

abstract：:The suppressive activity of two bovine serum albumin-specific class II-restricted T suppressor cell clones (BVI/5 and 83/2-D11) was compared to that of a feeder cell-independent, IL 2-dependent subline (HF1.IL-2) of an originally antigen-dependent class II-restricted Ts cell clone (HF1). No soluble suppressor factors ...

journal_title：Immunobiology

authors： Bettmann R,Degwert J,Heuer J,Kölsch E

更新日期：1987-05-01 00:00:00

abstract：:Activated macrophages have various characteristics in common with exudate and resident macrophages, but the ability to inhibit intracellular proliferation of the protozoa Toxoplasma gondii, the expression of Ia antigen and the capacity to produce H2O2 varies among these cells. Assessment of these features of macrophag...

journal_title：Immunobiology

authors： Nibbering PH,Langermans JA,van de Gevel JS,van der Hulst MB,van Furth R

更新日期：1991-12-01 00:00:00

abstract：:Airway epithelial cells induce a tolerogenic microenvironment by modulating immune cells in the lung. We recently showed that the supernatant of airway epithelial cells induces two marker genes of alternative activation, Ym1 and Ms4a8a, in respiratory myeloid cells. This induction was partially mediated by glucocortic...

journal_title：Immunobiology

authors： Ng Kuet Leong N,Brombacher F,Dalpke AH,Weitnauer M

更新日期：2017-05-01 00:00:00

abstract：:According to present concepts, innate immunity plays an important role in tumor surveillance and immune modulation. The state of NK cells depends on the balance between inhibitory and activating signals from corresponding receptors. As one of the activating receptors, NKG2D recognises some self ligands such as MICA/B ...

journal_title：Immunobiology

authors： Cao W,He W

更新日期：2004-01-01 00:00:00

abstract：:Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into...

journal_title：Immunobiology

authors： Du L,Wang S,Zhu Y,Zhao H,Basit A,Yu X,Li Q,Sun X

更新日期：2018-11-01 00:00:00

abstract：:The collectins are a group of innate immune proteins structurally characterized by their content of a carbohydrate recognition domain and a collagen-like region. Collectin liver 1 (CL-L1) and collectin 11 (CL-11, alias collectin kidney 1, CL-K1) are the more recently described members of this group. Their genomic orga...

journal_title：Immunobiology

authors： Selman L,Hansen S

更新日期：2012-09-01 00:00:00

abstract：:We utilized antisera specific for murine IL 1 alpha and IL 1 beta proteins to characterize cell-associated IL 1 according to two distinct criteria, immunochemical detection of radiolabeled IL 1 polypeptides and inhibition of IL 1 activity in cell lysates. Evidence is presented that IL 1 alpha and IL 1 beta are each sy...

journal_title：Immunobiology

authors： Günther C,Röllinghoff M,Beuscher HU

更新日期：1989-02-01 00:00:00

abstract：:T-lymphocytes, including Th17-cells and T-cells expressing acetylcholine (ACh), are key components of systemic inflammation in chronic obstructive pulmonary disease (COPD). We investigated whether ACh promotes Th17 cells in COPD. ACh, IL-17A, IL-22, RORγt, FOXP3 expression and AChIL-17A, AChIL-22, AChRORγt coexpressio...

journal_title：Immunobiology

authors： Profita M,Albano GD,Riccobono L,Di Sano C,Montalbano AM,Gagliardo R,Anzalone G,Bonanno A,Pieper MP,Gjomarkaj M

更新日期：2014-05-01 00:00:00