Calcium signalling by the high affinity macrophage Fc gamma receptor requires the cytosolic domain.

abstract：:Tumor necrosis factor (TNF) has been determined as an endogenous mediator for endotoxin-induced tumor necrosis. This macrophage product has been biochemically characterized and its protein structure defined by molecular cloning of the TNF gene. Experiments with antibodies to TNF demonstrated that TNF acts as an effect...

journal_title：Immunobiology

authors： Männel DN

更新日期：1986-09-01 00:00:00

abstract：:Culture supernatants (CS) from Hodgkin derived cell lines have previously been shown to contain colony stimulating activity (CSF) for human cord blood cells, fetal bone marrow and fetal liver cells. In this study 3-day CS from four Hodgkin lines (L428, L538, L540, L591) and two sublines (L428KS, L428KSA) were examined...

journal_title：Immunobiology

authors： Kortmann C,Burrichter H,Monner D,Jahn G,Diehl V,Peter HH

更新日期：1984-05-01 00:00:00

abstract：:Prior work demonstrated that a splice variant of SCN5A, a voltage-gated sodium channel gene, acts as a cytoplasmic sensor for viral dsRNA in human macrophages. Expression of this channel also polarizes macrophages to an anti-inflammatory phenotype in vitro and in vivo. Here we utilized global expression analysis of sp...

journal_title：Immunobiology

authors： White CR,Dungan M,Carrithers MD

更新日期：2019-01-01 00:00:00

abstract：:Ribosomal 30S and 50S subunits as well as total proteins from the large subunit of E. coli ribosomes were found to be potent mitogens for both human adult and cord blood lymphocytes. On the other hand, the RNA fraction of the 50S subunit had only a weak stimulatory capacity suggesting that the protein moiety contains ...

journal_title：Immunobiology

authors： Sieber G,Rühl H

更新日期：1980-01-01 00:00:00

abstract：:Hepatitis B virus (HBV) continues to be a serious worldwide health problem despite the use of protective HBV vaccines and therapeutic regimens against chronic HBV infection. Chronic HBV patients cannot induce sufficient immune responses against the virus. HBV and its antigens are believed to suppress immune responses ...

journal_title：Immunobiology

authors： Hatipoglu I,Ercan D,Acilan C,Basalp A,Durali D,Baykal AT

更新日期：2014-12-01 00:00:00

abstract：:Individuals infected with Strongyloides stercoralis have been reported to produce different immunoglobulins isotypes, yet few studies have evaluated their use in strongyloidiasis diagnosis. The aim of this work was to evaluate the immunoreactivity of different classes and subclasses of anti-S. stercoralis circulating ...

journal_title：Immunobiology

authors： De Souza JN,Cruz ADV,Araújo WAC,Sampaio LM,Allegretti SM,Teixeira MCA,Handali S,Galvão-Castro B,Soares NM

更新日期：2020-03-01 00:00:00

abstract：:Chitin and β-glucan are conserved throughout evolution in the fungal cell wall and are the most common polysaccharides in fungal species. Together, these two polysaccharides form a structural scaffold that is essential for the survival of the fungus. In the present study, we demonstrated that Aspergillus fumigatus alk...

journal_title：Immunobiology

authors： Dubey LK,Moeller JB,Schlosser A,Sorensen GL,Holmskov U

更新日期：2014-03-01 00:00:00

abstract：:Airway epithelial cells induce a tolerogenic microenvironment by modulating immune cells in the lung. We recently showed that the supernatant of airway epithelial cells induces two marker genes of alternative activation, Ym1 and Ms4a8a, in respiratory myeloid cells. This induction was partially mediated by glucocortic...

journal_title：Immunobiology

authors： Ng Kuet Leong N,Brombacher F,Dalpke AH,Weitnauer M

更新日期：2017-05-01 00:00:00

abstract：:Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...

journal_title：Immunobiology

authors： De Schryver M,Leemans A,Pintelon I,Cappoen D,Maes L,Caljon G,Cos P,Delputte PL

更新日期：2017-06-01 00:00:00

abstract：:Tuberculosis due to Mycobacterium tuberculosis infection is a leading cause of death worldwide. Recognition of this pathogen is crucial for the activation of innate and adaptive immune responses. Nucleotide-binding oligomerization domain (Nod)1 and Nod2 are cytoplasmic receptors that can detect unique muropeptides of ...

journal_title：Immunobiology

authors： Lee JY,Hwang EH,Kim DJ,Oh SM,Lee KB,Shin SJ,Park JH

更新日期：2016-01-01 00:00:00

abstract：:The prevailing paradigm defines sarcoidosis as a disease of unknown etiology characterized by a systemic noncaseating epithelioid granulomatous response (SGR). This formulation fails to account for the elusiveness of the etiological agent, the nature of the Kveim response, the paradox of cutaneous delayed type hyperse...

journal_title：Immunobiology

authors： Reich JM

更新日期：2017-04-01 00:00:00

abstract：:A long-lasting skin tolerance to non-H-2 alloantigens has been reported to be readily induced, when the recipient mice were primed intravenously (i.v.) with 5 x 10(7) spleen cells (SC) plus 1.5 x 10(7) bone marrow cells (BMC) from the H-2 identical strains of mice, and treated intraperitoneally (i.p.) with 200 mg/kg C...

journal_title：Immunobiology

authors： Tomita Y,Nomoto K

更新日期：1990-11-01 00:00:00

abstract：:Gammaherpesviruses (gammaHV) establish a life-long latency in the host and are associated with a number of malignant human diseases. It is generally believed that T cells play a major role in controlling the initial acute infection and subsequently maintaining the virus in a quiescent state. However, the nature of the...

journal_title：Immunobiology

authors： Woodland DL,Flaño E,Usherwood EJ,Liu Luzheng,Kim IJ,Husain SM,Sample JT,Blackman MA

更新日期：2001-12-01 00:00:00

abstract：:Cell walls from Streptococcus pyogenes strain Sv (Group A, M type 3) were lysed with M1 endo-N-acetylmuramidase, and the group A-specific carbohydrate antigen was purified by Sephadex G-100 gel filtration. The initial eluting antigen (M1gA) peak was assessed for mitogenic and polyclonal lymphocyte-activating propertie...

journal_title：Immunobiology

authors： Morisaki I,Kimura S,Torii M,Michalek SM,McGhee JR,Okahashi N,Hamada S

更新日期：1985-11-01 00:00:00

abstract：:The phenotype frequency of the platelet-specific antigens P1A1/A2 ( = Zw(a,b)) in the German population (N = 711) is 97.75% and 2.25% respectively. The corresponding gene frequencies are P1A1 0.85; P1A2 0.15. The P1A1 determinant is codominantly inherited (19 families; 151 family members). There is a strong gene dosag...

journal_title：Immunobiology

authors： Mueller-Eckhardt C,Marks HJ,Baur MP,Mueller-Eckhardt G

更新日期：1982-02-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Immunobiology

authors： Luo HL,Wang DY,Wang HJ,Nie K,Huang WY

更新日期：2011-12-16 00:00:00

abstract：:Although there have been numerous attempts to develop a successful vaccine against leishmaniasis, based on the clinical trial in this field, no vaccine against Leishmania in routine way can be found for globally effective vaccination in human. Amongst, first generation vaccines consisting of parasite fractions or whol...

journal_title：Immunobiology

authors： Jafari I,Heravi Shargh V,Shahryari M,Abbasi A,Jaafari MR,Khamesipour A,Badiee A

更新日期：2018-01-01 00:00:00

abstract：:There is extensive evidence for the critical role of reactive oxygen species (ROS) and nitric oxide (NO) produced by phagocytes in development of inflammatory processes and pathogenesis of numerous diseases, including rheumatoid arthritis (RA). Apart from their function as mediators of inflammation and tissue damage, ...

journal_title：Immunobiology

authors： Miletić T,Kovacević-Jovanović V,Vujić V,Stanojević S,Mitić K,Lazarević-Macanović M,Dimitrijević M

更新日期：2007-01-01 00:00:00

abstract：:The defective antigen presenting ability of antigen presenting cells (APCs) modulates host cytokines and co-stimulatory signals that may lead to severity of leprosy. In the present study, we sought to evaluate the phenotypic features of APCs along with whether DC SIGN (DC-specific intercellular adhesion molecule-grabb...

journal_title：Immunobiology

authors： Kumar S,Naqvi RA,Bhat AA,Rani R,Ali R,Agnihotri A,Khanna N,Rao DN

更新日期：2013-12-01 00:00:00

abstract：:We hypothesized that anti-citrullinated protein antibodies (ACPAs) could affect the expression of miRNAs in monocytes and contribute to the inflammatory responses in rheumatoid arthritis (RA). The expression profiles of 270 human miRNAs, co-cultured with ACPAs or human immunoglobulin G (IgG), were analyzed using real-...

journal_title：Immunobiology

authors： Lai NS,Yu HC,Yu CL,Koo M,Huang HB,Lu MC

更新日期：2015-12-01 00:00:00

abstract：:We have examined the role of CD26 (dipeptidyl peptidase IV) in the adhesion of resting and activated T lymphocytes to endothelial cells and fibroblasts. For this purpose, we ran a short-time adhesion assay under different strategies: Adhesion of T lymphocytes was determined in the presence of different anti-CD26 monoc...

journal_title：Immunobiology

authors： Mattern T,Reich C,Schönbeck U,Ansorge S,Demuth HU,Loppnow H,Ulmer AJ,Flad HD

更新日期：1998-02-01 00:00:00

abstract：:The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism. We could demo...

journal_title：Immunobiology

authors： Wirth T,Pfisterer P,Annweiler A,Zwilling S,König H

更新日期：1995-07-01 00:00:00

abstract：:The aim of the work was to justify the use of trifluoromethyl-dinitrobenzene sulfonate (CF3-DNBS) modification rather than trinitrobenzene-sulfonate (TNBS) modification, so as to be able to take advantage of the presence of fluorine atoms in the analogue, which allow the analysis of the hapten-carrier bonds by 19F-NMR...

journal_title：Immunobiology

authors： Bischoff P,Maugras M,Llorens MC,Oth D

更新日期：1983-02-01 00:00:00

abstract：:Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study,...

journal_title：Immunobiology

authors： Ogita T,Bergamo P,Maurano F,D'Arienzo R,Mazzarella G,Bozzella G,Luongo D,Sashihara T,Suzuki T,Tanabe S,Rossi M

更新日期：2015-06-01 00:00:00

abstract：:The anticonvulsant drug phenytoin, in less than cytotoxic concentrations, caused significant reductions in Ig secretion by unstimulated or EBV-stimulated normal MNC, as measured by PFC or secretion of Ig into the culture medium. Isotype-specific LBL varied in their sensitivity, the secretion of IgA (1 line) and IgG (3...

journal_title：Immunobiology

authors： Wangel AG,Arvilommi H,Jokinen I

更新日期：1985-09-01 00:00:00

abstract：:Mast cells serve important roles as sentinels against bacterial infection by secreting mediators stored in granules. Much of their effectiveness depends upon recruiting and/or modulating other immune cells. The location of mast cells implies that they recognize pathogens invading tissues or mucosal tissues. Acinetobac...

journal_title：Immunobiology

authors： Kikuchi-Ueda T,Kamoshida G,Ubagai T,Nakano R,Nakano A,Akuta T,Hikosaka K,Tansho-Nagakawa S,Kikuchi H,Ono Y

更新日期：2017-11-01 00:00:00

abstract：:The activating C-type lectin-like receptor NKG2D, which is expressed by mouse NK cells and activated CD8 T cells, was previously demonstrated to be involved in tumor rejection and as a defense mechanism against viral and bacterial infections. Because CD8 T cells are important for protective immune responses during chr...

journal_title：Immunobiology

authors： Hessmann M,Rausch A,Rückerl D,Adams PS,Simon M,Gilfillan S,Colonna M,Ehlers S,Hölscher C

更新日期：2011-05-01 00:00:00

abstract：:Previous work has shown that purified rat macrophages lack both accessory activity for T lymphocyte responses to mitogens and stimulatory activity in a mixed leukocyte reaction, in marked contrast to the potent activity of dendritic cells. This study was designed to re-evaluate macrophages as accessory cells by treati...

journal_title：Immunobiology

authors： Bowers WE,Ruhoff MS,Goodell EM,Stoltenborg JK

更新日期：1988-02-01 00:00:00

abstract：:The mechanisms that mediate accelerated atherosclerosis in autoimmune diseases remain unclear. One common mechanism that has been documented in autoimmune diseases and atherosclerosis is formation of hypoglycosyalted N-glycans on the cell surface. In this study we tested the effects of swainsonine, a class II α-mannos...

journal_title：Immunobiology

authors： Scott DW,Black LL,Vallejo MO,Kabarowski JH,Patel RP

更新日期：2014-07-01 00:00:00

abstract：:Cartilage-hair hypoplasia (CHH), or McKusick type metaphyseal chondrodysplasia, was first recognized as a distinct entity in the Old Order Amish in the USA, but was later identified in other groups, and found to be unusually frequent among Finns. CHH is highly pleiotropic with manifestations that include short stature...

journal_title：Immunobiology

authors： Muñoz-Robles J,Allende LM,Clemente J,Calleja S,Varela P,Gonzalez L,de Pablos P,Paz E,Morales P

更新日期：2006-01-01 00:00:00