Abstract：
:The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism. We could demonstrate that octamer-dependent transcription is not only regulated by specific DNA-binding transcription factors, but in addition requires the activity of B cell-restricted cofactors. Both octamer-dependent promoter and enhancer activation depend on such a combination of transcription factor and cofactors. However, the exact requirements differ for these two situations. Promoter activity can be achieved with either one of two distinct transcription factors, Oct1 and/or Oct2, together with the cofactor OCA-B1. In contrast, only Oct2 in conjunction with an additional cofactor, OCA-B2, can confer enhancer activity.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Wirth T,Pfisterer P,Annweiler A,Zwilling S,König Hdoi
10.1016/S0171-2985(11)80540-1subject
Has Abstractpub_date
1995-07-01 00:00:00pages
161-70issue
2-4eissn
0171-2985issn
1878-3279pii
S0171-2985(11)80540-1journal_volume
193pub_type
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