Abstract:
:Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important role in the maintenance of innate immunity in organs such as the lungs and intestines where it proteolytically activates anti-bacterial peptides such as pro-defensins. MMP-7 is also important for mediating proteolytic release of TNF from macrophages. Consistent with its role in innate immunity, MMP-7 is induced by microbial products and also, unexpectedly, by hypoxia.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Burke Bdoi
10.1016/j.imbio.2004.04.005subject
Has Abstractpub_date
2004-01-01 00:00:00pages
51-6issue
1-2eissn
0171-2985issn
1878-3279pii
S0171-2985(04)00020-8journal_volume
209pub_type
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