Do resident macrophages proliferate?

abstract：:Peptide immunotherapy (PIT) represents a safe and efficacious therapeutic modality for allergic diseases. Present study evaluates immunotherapeutic potential of T cell peptides of major cockroach allergen, Per a 10 in murine model of airway allergy. Treatment with peptides T-P8 and T-P10 demonstrated maximal resolutio...

journal_title：Immunobiology

authors： Govindaraj D,Sharma S,Singh N,Arora N

更新日期：2019-05-01 00:00:00

abstract：:The leukocyte integrins CD11a/CD18 (LFA-1, alphaLbeta2) and CD49d (VLA-4, alpha4beta1, alpha4beta7) mediate leukocyte transendothelial migration during immune and inflammatory responses and provides co-stimulatory signals for the activation of T lymphocytes. Our previous studies demonstrate that the CD11a gene promote...

journal_title：Immunobiology

authors： Domínguez-Soto A,Relloso M,Vega MA,Corbí AL,Puig-Kröger A

更新日期：2005-01-01 00:00:00

abstract：:Neopterin is produced in large amounts specifically from macrophages upon stimulation with interferon-gamma (IFN-gamma). Measurement of neopterin allows a direct in vivo quantification of T cell activation. This is particularly useful, e.g., in early diagnosis of graft rejection. Since disease states with elevated neo...

journal_title：Immunobiology

authors： Fuchs D,Ebell W,Friedrich W,Hausen A,Reibnegger G,Werner ER,Wachter H

更新日期：1988-04-01 00:00:00

abstract：:Psoriatic inflammation has been shown to be associated with cardiovascular dysfunction and systemic inflammation. Recently, psoriasis has also been linked to hepatic disorders, however underlying mechanism connecting the two are unknown. IL-17A being a central pro-inflammatory cytokine in the pathogenesis of psoriasis...

journal_title：Immunobiology

authors： Al-Harbi NO,Nadeem A,Al-Harbi MM,Zoheir KMA,Ansari MA,El-Sherbeeny AM,Alanazi KM,Alotaibi MR,Ahmad SF

更新日期：2017-02-01 00:00:00

abstract：:α-Synuclein plays a crucial role in Parkinson's disease and dementias defined as synucleinopathies. α-Synuclein is expressed in hematopoietic and immune cells, but its functions in hematopoiesis and immune responses are unknown. We utilized α-synuclein(-/-) (KO) mice to investigate its role in hematopoiesis and B cell...

journal_title：Immunobiology

authors： Xiao W,Shameli A,Harding CV,Meyerson HJ,Maitta RW

更新日期：2014-11-01 00:00:00

abstract：:To investigate the role of IL-13 during a severe systemic Candida albicans infection, BALB/c control and IL-13-/- mice were examined for colony forming units (CFU) in the kidneys and survival days after intravenous infection. Proinflammatory mediators and cell recruitment into the tissue were measured by quantitative ...

journal_title：Immunobiology

authors： Abe Y,Yamamoto N,Nakamura K,Arai K,Sakurai C,Hatsuzawa K,Ogura Y,Iseki K,Tase C,Kanemitsu K

更新日期：2019-01-01 00:00:00

abstract：:The homotypic cell aggregation of leukocytes is an unique adhesive event which is caused by cellular activation. Anti-CD44 monoclonal antibody (mAb) induces homotypic cell aggregation of hematopoietic cell lines expressing CD44, but the mechanism of homotypic cell aggregation is poorly understood. We used four mAbs ag...

journal_title：Immunobiology

authors： Cao L,Yoshino T,Nishiuchi R,Yamadori I,Akagi T

更新日期：1995-06-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease characterized by progressive airflow limitation, chronic respiratory symptoms and frequent exacerbations. There is an unmet need to identify novel therapeutic alternatives beside bronchodilators that prevent disease progression. Levels of both...

journal_title：Immunobiology

authors： Douaoui S,Djidjik R,Boubakeur M,Ghernaout M,Touil-Boukoffa C,Oumouna M,Derrar F,Amrani Y

更新日期：2020-05-01 00:00:00

abstract：:The concept of using mesenchymal stem cells (MSCs) in bone repair has progressively evolved, and the goal of cell-mediated therapy is to prolong the natural physiological abilities of healing, or substitute them, when these are lacking, failing, or progressing too slowly. The future application of MSCs in human therap...

journal_title：Immunobiology

authors： Zhang X,Tang T,Shi Q,Fernandes JC,Dai K

更新日期：2009-01-01 00:00:00

abstract：:A long-lasting skin tolerance to non-H-2 alloantigens has been reported to be readily induced, when the recipient mice were primed intravenously (i.v.) with 5 x 10(7) spleen cells (SC) plus 1.5 x 10(7) bone marrow cells (BMC) from the H-2 identical strains of mice, and treated intraperitoneally (i.p.) with 200 mg/kg C...

journal_title：Immunobiology

authors： Tomita Y,Nomoto K

更新日期：1990-11-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells capable of abrogating T and B cells responses and have been identified in numerous cancers. As with other regulatory cell populations, they aim to maintain balance between host-defence-associated inflammation and ensuing tissue pathology. MDSC accumulati...

journal_title：Immunobiology

authors： Tamadaho RSE,Hoerauf A,Layland LE

更新日期：2018-01-01 00:00:00

abstract：:"Brucelline INRA" is an aqueous extract of a rough strain of Brucella melitensis that is used to test cutaneous delayed hypersensitivity in man and animals. The cellular response of mice (either normal, or sensitized by a previous brucella infection) was investigated with local implanted "cell-traps" and by immunologi...

journal_title：Immunobiology

authors： Bureau JP,Caravano R,Garelli L,Lemaire J

更新日期：1989-03-01 00:00:00

abstract：:Purified CD8+ T cells from influenza A/WSN-immune BALB/c (H-2d) mice respond with the generation of secondary A/WSN-specific Tc cells in vitro when stimulated with a synthetic peptide (NPP) with a sequence derived from influenza A virus nucleoprotein with high affinity for Kd class I MHC molecules. The process of the ...

journal_title：Immunobiology

authors： Kos FJ,Müllbacher A

更新日期：1992-11-01 00:00:00

abstract：:Cytokines are important mediators of the effects observed after the administration of endotoxin. One of them, tumor necrosis factor, is particularly important since it plays a cardinal role in two major endotoxin activities: its antitumor effect and its capacity to induce a systemic inflammatory response syndrome. TNF...

journal_title：Immunobiology

authors： Brouckaert P,Libert C,Everaerdt B,Takahashi N,Cauwels A,Fiers W

更新日期：1993-04-01 00:00:00

abstract：:The prevailing paradigm defines sarcoidosis as a disease of unknown etiology characterized by a systemic noncaseating epithelioid granulomatous response (SGR). This formulation fails to account for the elusiveness of the etiological agent, the nature of the Kveim response, the paradox of cutaneous delayed type hyperse...

journal_title：Immunobiology

authors： Reich JM

更新日期：2017-04-01 00:00:00

abstract：:Dogs infected with Leishmania infantum have a reduced number of T lymphocytes. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family that is expressed by immune cells, and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces the deactivation or apoptosis of T cells. This study aimed to evaluate the expres...

journal_title：Immunobiology

authors： Chiku VM,Silva KL,de Almeida BF,Venturin GL,Leal AA,de Martini CC,de Rezende Eugênio F,Dos Santos PS,de Lima VM

更新日期：2016-08-01 00:00:00

abstract：:CD45RA monoclonal antibodies recognize the higher molecular weight isoforms (220 and 205 kDa) of leukocyte common antigen family (CD45), which are typically expressed on B cells and unstimulated T cells. We have found that there are at least three distinct CD45RA monoclonal antibodies which react with platelet 42 kDa ...

journal_title：Immunobiology

authors： Holada K,Dyr JE,Koubek K,Suttnar J,Simák J

更新日期：1995-02-01 00:00:00

abstract：:Both the complement system and collectins play important roles in our innate immune system. The collectins, which are characterized by their inclusion of a collagen-like region and a calcium-dependent carbohydrate recognition domain, are pattern recognition molecules and include the well characterized proteins mannan-...

journal_title：Immunobiology

authors： Hansen SW,Ohtani K,Roy N,Wakamiya N

更新日期：2016-10-01 00:00:00

abstract：:In mice, monoclonal antibody (mAb) to the alpha1 integrin abrogate gastro-intestinal damage during graft-versus-host-disease (GVHD), suggesting anti alpha1 mAb as candidates for treatment in humans as well. Our current data show that one such reagent, mAb 1B3.1, when immobilized to plastic wells via rabbit- anti murin...

journal_title：Immunobiology

authors： Bank I,Hardan I,Lokshin E,Nas D,Miron S,Ohad D,Spong S,Garrod DR

更新日期：2000-09-01 00:00:00

abstract：:When sheep red blood cells (SRBC) were injected intraperitoneally (i.p.), intravenously (i.v.), or into the Peyer's patches, definite plaque-forming cell (PFC) and rosette-forming cell (RFC) responses were induced in the spleen but not in the mesenteric lymph nodes (MLN). When SRBC were injected directly into the sple...

journal_title：Immunobiology

authors： Kojima T,Kamei H,Kondo T,Nakashima I,Kato N

更新日期：1982-05-01 00:00:00

abstract：:Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activat...

journal_title：Immunobiology

authors： Nymo S,Niyonzima N,Espevik T,Mollnes TE

更新日期：2014-10-01 00:00:00

abstract：:To recognize patients with inhibitory and neutralizing auto-antibodies to interferon-γ (AutoAbs-IFN-γ) presenting with the sporadic phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) mainly characterized by recurrent intracellular mycobacterium or/and salmonella infections, we comprehensively invest...

journal_title：Immunobiology

authors： Lee WI,Huang JL,Wu TS,Lee MH,Chen IJ,Yu KH,Liu CY,Yang CH,Hsieh MY,Lin YL,Shih YF,Jaing TH,Huang SC,Kuo TT,Ku CL

更新日期：2013-05-01 00:00:00

abstract：:Human recombinant erythropoietin (rHuEPO) has been purified to apparent homogeneity and compared to purified human urinary erythropoietin (EPO). Both the purified natural and recombinant EPO preparations were characterized in a competition radioimmunoassay (RIA), the exhypoxic polycythemic mouse bioassay, in vitro tis...

journal_title：Immunobiology

authors： Egrie JC,Strickland TW,Lane J,Aoki K,Cohen AM,Smalling R,Trail G,Lin FK,Browne JK,Hines DK

更新日期：1986-09-01 00:00:00

abstract：:Autoantibodies against DNA topoisomerase I (anti-topo I) have been reported to be specific to systemic sclerosis (SSc), however, anti-topo I was detected in patients with silicone breast implants, SLE without features of SSc, and rheumatic diseases. We detected anti-topo I positive silicosis patients without any sympt...

journal_title：Immunobiology

authors： Ueki A,Isozaki Y,Tomokuni A,Ueki H,Kusaka M,Tanaka S,Otsuki T,Sakaguchi H,Hyodoh F

更新日期：2001-12-01 00:00:00

abstract：:Previous studies have demonstrated that methamphetamine (METH) alter inflammatory and anti-inflammatory cytokine production in the periphery. However, the effect of METH on lipopolysaccharide (LPS)-induced immune responses and its underlying mechanism of action remains unclear. The dopamine D3 receptor (D3R) plays an ...

journal_title：Immunobiology

authors： Xue L,Li X,Ren HX,Wu F,Li M,Wang B,Chen FY,Cheng WY,Li JP,Chen YJ,Chen T

更新日期：2015-06-01 00:00:00

abstract：:The activation of cytotoxic T lymphocytes (CTL) in vivo was found to be augmented by glutathione if injected i.p. in the late phase but not in the early phase of the response. The effect of glutathione possibly resembles the augmenting effect of 2-mercaptoethanol in lymphocyte cultures. ...

journal_title：Immunobiology

authors： Dröge W,Pottmeyer-Gerber C,Schmidt H,Nick S

更新日期：1986-08-01 00:00:00

abstract：:Individuals infected with Strongyloides stercoralis have been reported to produce different immunoglobulins isotypes, yet few studies have evaluated their use in strongyloidiasis diagnosis. The aim of this work was to evaluate the immunoreactivity of different classes and subclasses of anti-S. stercoralis circulating ...

journal_title：Immunobiology

authors： De Souza JN,Cruz ADV,Araújo WAC,Sampaio LM,Allegretti SM,Teixeira MCA,Handali S,Galvão-Castro B,Soares NM

更新日期：2020-03-01 00:00:00

abstract：:The vitamin D receptor (VDR) is a hormone nuclear receptor regulating bone and calcium homeostasis. Studies revealing the expression of VDR on immune cells point toward a role for VDR-dependent signaling pathways in immunity. Here we verified the ability of the natural VDR ligand, 1,25-dihydroxyvitamin D(3) (1,25(OH)(...

journal_title：Immunobiology

authors： Korf H,Wenes M,Stijlemans B,Takiishi T,Robert S,Miani M,Eizirik DL,Gysemans C,Mathieu C

更新日期：2012-12-01 00:00:00

abstract：:Beside the lung, thoracic lymph nodes are most affected during silicosis. The mechanisms leading to enlargement of the lymph nodes and partial activation of lymph node cells are still unclear. The present study demonstrates an increase in iNOS mRNA expression in the lung draining lymph nodes of rats at 1, 2, and 8 mon...

journal_title：Immunobiology

authors： Friedetzky A,Grau V,Wieckenberg M,Lewen A,Gemsa D,Garn H

更新日期：2002-07-01 00:00:00

abstract：:This study demonstrates immune complexes in thyroid glands of Obese strain (OS) chickens, that consist of thyroglobulin (Tg) and antibodies to Tg. In IIF tests it was shown that these complexes fix complement with an age-dependent increase from 12% in 19-day-old embryos up to 100% in 6-week-old animals. This finding a...

journal_title：Immunobiology

authors： Kofler H,Kofler R,Wolf H,Wick G

更新日期：1983-05-01 00:00:00