Abstract:
:CD45RA monoclonal antibodies recognize the higher molecular weight isoforms (220 and 205 kDa) of leukocyte common antigen family (CD45), which are typically expressed on B cells and unstimulated T cells. We have found that there are at least three distinct CD45RA monoclonal antibodies which react with platelet 42 kDa (P42) intracellular protein antigen, which seems to be different from any to date described platelet proteins with similar molecular weight. This platelet antigen is a single chain protein, very likely not a glykoprotein, with isoelectrical point between 6.8 and 7.5. P42 does not seem to be a membrane protein and is not associated with platelet cytoskeleton. Results of immunofluorescence assay suggest that P42 may be redistributed to platelet surface after platelet aggregation.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Holada K,Dyr JE,Koubek K,Suttnar J,Simák Jdoi
10.1016/s0171-2985(11)80103-8subject
Has Abstractpub_date
1995-02-01 00:00:00pages
272-7issue
3-4eissn
0171-2985issn
1878-3279pii
S0171-2985(11)80103-8journal_volume
192pub_type
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