C1q receptors: regulating specific functions of phagocytic cells.

abstract：:We have previously generated a murine anti-idiotype (Ab2) monoclonal antibody (mAb) to a murine Ab1 mAb, named P3, which selectively binds Neu-glycolyl (NeuGc)-sialic acid on several monosialo- and disialogangliosides, and also reacts with sulfatides and antigens expressed in human melanoma and breast tumors. This Ab2...

journal_title：Immunobiology

authors： Hernández AM,Rodríguez M,López-Requena A,Beausoleil I,Pérez R,Vázquez AM

更新日期：2005-01-01 00:00:00

abstract：:Infectious bursal disesase is a highly contagious, wide spread immunosuppressive chicken disease caused by the Infectious Bursal Disease Virus (IBDV). IBDV is a two segmented double-strand RNA virus, member of the Birnaviridae family. In order to study the interaction between IBDV and the immune system, chickens were ...

journal_title：Immunobiology

authors： Carballeda JM,Zoth SC,Gómez E,Gravisaco MJ,Berinstein A

更新日期：2011-09-01 00:00:00

abstract：:It is well known that adherence of monocytes (MO) to extracellular matrix substrates or tissue culture plastic activates these cells and induces the expression of a multitude of genes. Especially, it was described, that MO are primed by cell adhesion to produce higher amounts of some cytokines, e.g. interleukin (IL)-8...

journal_title：Immunobiology

authors： Krause SW,Kreutz M,Andreesen R

更新日期：1996-01-01 00:00:00

abstract：:IL-33 targeting ST2 receptor (T1/ST2), expressed on Th2 cell surface, regulates the production of cytokines like IL-17A and IL-31. We studied the role of IL-33/ST2 axis in IL-31 and IL-17A production in patients with allergic rhinitis (AR) and with concomitant allergic asthma and rhinitis (AAR). 20 healthy control sub...

journal_title：Immunobiology

authors： Vocca L,Di Sano C,Uasuf CG,Sala A,Riccobono L,Gangemi S,Albano GD,Bonanno A,Gagliardo R,Profita M

更新日期：2015-08-01 00:00:00

abstract：:NK-92 cell line has been used as anti-tumor cytotoxic effector cells in immunotherapy. Leucine-rich repeats and calponin homology domain containing 1 (LRCH1) is a novel gene of which the function is unclear. In the present study, we investigated the role of LRCH1 in NK-92 cell cytotoxicity. LRCH1 was ablated in NK-92 ...

journal_title：Immunobiology

authors： Dai K,Chen Z,She S,Shi J,Zhu J,Huang Y

更新日期：2020-05-01 00:00:00

abstract：:Spleen exposure to ultrasound has been reported to influence antibody response to sheep red blood cell injection in mice (decreased hemagglutination and hemolytic titers and IgM, IgG2a and IgG2b levels and elevated IgG1 levels). In a controlled clinical trial, we investigated the possible immunosuppressive side-effect...

journal_title：Immunobiology

authors： Berthold F,Berthold R,Matter I,Reither M,Rother U,Skvaril F,Willems WR

更新日期：1982-01-01 00:00:00

abstract：:The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25, cytotoxic T lymphoc...

journal_title：Immunobiology

authors： Kreiser S,Eckhardt J,Kuhnt C,Stein M,Krzyzak L,Seitz C,Tucher C,Knippertz I,Becker C,Günther C,Steinkasserer A,Lechmann M

更新日期：2015-02-01 00:00:00

abstract：:Efficient immunoglobulin (Ig) production was induced when human B cells were cultured with autologous T cells activated by immobilized CD3 mAb in cultures supplemented with IL-2. Negatively purified B cells or B cells positively selected with mAb to CD19, CD21 or CD72 surface antigens produced IgM, IgG and IgA, wherea...

journal_title：Immunobiology

authors： Ling NR,Lowe JL

更新日期：1993-12-01 00:00:00

abstract：:Human urinary colony-stimulating factor (CSF-HU) has been partially purified using five purification procedures (preparation II) for clinical use. In phase I study, six healthy volunteers were injected with preparation II of CSF-HU by a single intravenous droplet infusion. Two volunteers received 4 X 10(6) units (U), ...

journal_title：Immunobiology

authors： Motoyoshi K,Ishizaka Y,Miura Y,Takaku F

更新日期：1986-09-01 00:00:00

abstract：:Immunological mechanisms of hygiene hypothesis are expected to develop a novel strategy for allergy prevention. Although a large number of studies has investigated the relation between allergies and infection, little is known about the influence of the exposure to infections on antigen uptake by dendritic cells (DCs)....

journal_title：Immunobiology

authors： Mizuno N,Sasaki Y,Segawa R,Asakawa S,Hiratsuka M,Hirasawa N

更新日期：2018-01-01 00:00:00

abstract：:This study assessed variation in plasma levels of the complement regulatorC1 inhibitor (C1inh) in patients with age related macular degeneration (AMD) and controls. Plasma from391 AMD cases and 370 controls was assayed by rate nephelometry to determine C1inh protein levels. Protein levels were analysed for relationshi...

journal_title：Immunobiology

authors： Gibson J,Hakobyan S,Cree AJ,Collins A,Harris CL,Ennis S,Morgan BP,Lotery AJ

更新日期：2012-02-01 00:00:00

abstract：:Beside the lung, thoracic lymph nodes are most affected during silicosis. The mechanisms leading to enlargement of the lymph nodes and partial activation of lymph node cells are still unclear. The present study demonstrates an increase in iNOS mRNA expression in the lung draining lymph nodes of rats at 1, 2, and 8 mon...

journal_title：Immunobiology

authors： Friedetzky A,Grau V,Wieckenberg M,Lewen A,Gemsa D,Garn H

更新日期：2002-07-01 00:00:00

abstract：:Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxi...

journal_title：Immunobiology

authors： Benczur M,Györffy G,Garam T,Varga M,Medgyesi G,Sándor M,Petranyi GG

更新日期：1979-09-01 00:00:00

abstract：:Acute Myeloid Leukaemia (AML) is a neoplasia characterised by rapid proliferation and an increased rate of relapses. The AML blasts display features of antigen-presenting cells (APC), and thus can directly modulate the anti-tumour T cell responses. The bone marrow of a group consisting of 30 newly diagnosed patients a...

journal_title：Immunobiology

authors： Antohe I,Tanasa MP,Dăscălescu A,Dănăilă C,Titieanu A,Zlei M,Ivanov I,Sireteanu A,Cianga P

更新日期：2020-12-03 00:00:00

abstract：:Ribosomal 30S and 50S subunits as well as total proteins from the large subunit of E. coli ribosomes were found to be potent mitogens for both human adult and cord blood lymphocytes. On the other hand, the RNA fraction of the 50S subunit had only a weak stimulatory capacity suggesting that the protein moiety contains ...

journal_title：Immunobiology

authors： Sieber G,Rühl H

更新日期：1980-01-01 00:00:00

abstract：:Gaucher disease (GD) is associated with upregulation of CD1d and MHC-class II expression by monocytes. While the physiological impact of CD1d upregulation remains uncertain, it has been proposed that MHC-class II upregulation is associated with inflammation. Hereby, we show that the decrease in MHC-class II expression...

journal_title：Immunobiology

authors： Balreira A,Cavallari M,Sá Miranda MC,Arosa FA

更新日期：2010-06-01 00:00:00

abstract：:People deficient in C1-INH present recurrent angioedema localized to subcutaneous or mucous tissues. The defect can be caused by impaired synthesis, due to a genetic defect (hereditary angioedema), or by increased catabolism (acquired angioedema). In our experience the majority of patients with acquired angioedema (16...

journal_title：Immunobiology

authors： Cicardi M,Bergamaschini L,Cugno M,Beretta A,Zingale LC,Colombo M,Agostoni A

更新日期：1998-08-01 00:00:00

abstract：:Dendritic cells capture and process antigen and present it to T lymphocytes in the lymphoid organs. Dendritic cells of the skin, including epidermal Langerhans cells, langerin(+) and langerin(negative) dermal dendritic cells are ideally positioned to take up pathogens that enter the body through the skin or vaccines t...

journal_title：Immunobiology

authors： Sparber F,Tripp CH,Hermann M,Romani N,Stoitzner P

更新日期：2010-09-01 00:00:00

abstract：:Numerous studies have shown that over-activation of microglia could cause neuroinflammation and release pro-inflammatory mediators, which could result in neurodegenerative diseases, like Parkinson's disease, Alzheimer's disease etc. Beta-naphthoflavone (BNF) has anti-oxidant and anti-inflammatory effects in borderline...

journal_title：Immunobiology

authors： Gao X,He D,Liu D,Hu G,Zhang Y,Meng T,Su Y,Zhou A,Huang B,Du J,Fu S

更新日期：2020-07-01 00:00:00

abstract：:We were able to characterize about 25 antigenic proteins of cultured synovial fibroblasts with apparent molecular weights of 15-230 kd by SDS-electrophoresis and immunoblotting using guinea pig antiserum. Some of these proteins were bovine-serum-derived, adsorbed onto fibroblasts from culture medium. Both rheumatoid a...

journal_title：Immunobiology

authors： Heino J,Kouri T,Jalkanen M,Lehtonen OP

更新日期：1984-05-01 00:00:00

abstract：:The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism. We could demo...

journal_title：Immunobiology

authors： Wirth T,Pfisterer P,Annweiler A,Zwilling S,König H

更新日期：1995-07-01 00:00:00

abstract：:Interleukin (IL)-27, a member of the IL-6/IL-12 heterodimeric cytokine family, induces pro-inflammatory responses including early T helper (Th)1 differentiation and generation of cytotoxic T lymphocytes, and also anti-inflammatory responses including the differentiation to IL-10-producing regulatory T cells, inhibitio...

journal_title：Immunobiology

authors： Shimizu M,Ogura K,Mizoguchi I,Chiba Y,Higuchi K,Ohtsuka H,Mizuguchi J,Yoshimoto T

更新日期：2013-04-01 00:00:00

abstract：:Vitamin D [25(OH)D3] deficiency has been associated with asthma as in many inflammatory and autoimmune pathologies; however, there is still a lack of data about the effects of administration of vitamin D in immune regulation in young asthmatic patients. In this study, we investigated its inhibitory effect on the immun...

journal_title：Immunobiology

authors： Hamzaoui A,Berraïes A,Hamdi B,Kaabachi W,Ammar J,Hamzaoui K

更新日期：2014-11-01 00:00:00

abstract：:We studied immunohistological and biochemical aspects of the CD44 molecule with a mAb produced in our lab: GRHL-1. The characteristic expression of this antigen in cells of B lineage was analyzed. This mAb showed identical immunohistological patterns of reactivity to other mAbs included in CD44 cluster, on a variety l...

journal_title：Immunobiology

authors： Collado A,de Andres A,Cañadas E,Ruiz-Cabello F,Gomez O,Pedrinaci S,Garrido F

更新日期：1991-09-01 00:00:00

abstract：:BALB/c mice injected with 0.2 mg TNP-ovalbumin (OA) within 24 hours after birth showed reduced levels of functionally active TNP-specific B cells and, accordingly, of plaque-forming cells (PFC) after challenge with carrier-bound TNP until the age of 8 weeks. Yet, when B cells of tolerized mice were cultured in the abs...

journal_title：Immunobiology

authors： Zöller M,Andrighetto G

更新日期：1987-12-01 00:00:00

abstract：:A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of ...

journal_title：Immunobiology

authors： Peranzoni E,Marigo I,Dolcetti L,Ugel S,Sonda N,Taschin E,Mantelli B,Bronte V,Zanovello P

更新日期：2007-01-01 00:00:00

abstract：:Activated macrophages have various characteristics in common with exudate and resident macrophages, but the ability to inhibit intracellular proliferation of the protozoa Toxoplasma gondii, the expression of Ia antigen and the capacity to produce H2O2 varies among these cells. Assessment of these features of macrophag...

journal_title：Immunobiology

authors： Nibbering PH,Langermans JA,van de Gevel JS,van der Hulst MB,van Furth R

更新日期：1991-12-01 00:00:00

abstract：:This study tested the hypothesis that prolonged severe hypoxia during monocyte to macrophage differentiation results in macrophages with a pattern of gene expression and phenotype distinct from those maturing in normal oxygen levels. Macrophages accumulate in hypoxic and anoxic areas within pathological sites such as ...

journal_title：Immunobiology

authors： Staples KJ,Sotoodehnejadnematalahi F,Pearson H,Frankenberger M,Francescut L,Ziegler-Heitbrock L,Burke B

更新日期：2011-07-01 00:00:00

abstract：:Fifty-nine patients with metastatic malignant melanoma were entered into a phase II trial of recombinant alpha-2 interferon given in a dosage of 10 million IU/M2 subcutaneously three times per week for one year. Forty-five of these were evaluable for response. Of five evaluable patients with ocular primaries, none res...

journal_title：Immunobiology

authors： Robinson WA,Mughal TI,Thomas MR,Johnson M,Spiegel RJ

更新日期：1986-09-01 00:00:00

abstract：:Three different anti-CD26 monoclonal antibodies (mAbs) are described, which specifically inhibited proliferation of human T lymphocytes after stimulation with PHA, tetanus toxoid or soluble anti-CD3 mAb. Anti-CD26 mAbs induced in T cells a dose-dependent shift of the maximum of DNA synthesis, which was due to a transi...

journal_title：Immunobiology

authors： Mattern T,Ansorge S,Flad HD,Ulmer AJ

更新日期：1993-06-01 00:00:00