Abstract：
:A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of the amino acid l-arginine. Myeloid cells exert various, often divergent, actions on the immune response through mechanisms that exploit mediators of this peculiar metabolic pathway, ranging from l-arginine itself to its downstream metabolites, like nitric oxide and polyamines. Various pathological situations, including neoplastic and autoimmune diseases, as well as injury repair and infections are discussed here, showing how l-arginine metabolism is able to play a dual role, both as an active protector and a possible threat to the organism.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Peranzoni E,Marigo I,Dolcetti L,Ugel S,Sonda N,Taschin E,Mantelli B,Bronte V,Zanovello Pdoi
10.1016/j.imbio.2007.09.008subject
Has Abstractpub_date
2007-01-01 00:00:00pages
795-812issue
9-10eissn
0171-2985issn
1878-3279pii
S0171-2985(07)00113-1journal_volume
212pub_type
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