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Characterization of CD44 antigen during lymphoid ontogeny.

Abstract：

:We studied immunohistological and biochemical aspects of the CD44 molecule with a mAb produced in our lab: GRHL-1. The characteristic expression of this antigen in cells of B lineage was analyzed. This mAb showed identical immunohistological patterns of reactivity to other mAbs included in CD44 cluster, on a variety lymphoid and nonlymphoid human tissues, and demonstrated similar bands on SDS-PAGE of 125I labeled lymphocyte lysates. This antigen is limited to cells of mature phenotype, and disappears in proliferating B cells in the germinal centers of the lymphoid follicles. CD44 is absent in pre-B and Burkitt cell lines. PKC activation mediate in vitro differentiation of pre-B cell lines. However, it is not involved in up-regulation of CD44 antigen expression.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Collado A,de Andres A,Cañadas E,Ruiz-Cabello F,Gomez O,Pedrinaci S,Garrido F

doi

10.1016/S0171-2985(11)80181-6

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

1-11

issue

1-2

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(11)80181-6

journal_volume

183

pub_type

杂志文章

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