Abstract：
:Details of the "Trojan Horse" mechanism by which Zika virus (ZIKV) crosses the blood-brain barrier (BBB) remain unclear. However, the migration of ZIKV-infected monocytes to the brain is thought to be dependent on both pattern-recognition and chemokine receptors. In this study, we investigated whether the migration of ZIKV-infected MonoMac-1 (MM-1) cells through the BBB is dependent on chemokine receptor 7 (CCR7) and receptor for advanced glycation end (RAGE); we also determined whether high mobility group box protein 1 (HMGB1) could facilitate the permeabilization of endothelial cells. We demonstrated that ZIKV infects MM-1 cells, leading to milieu accumulation of HMGB1. Our results suggest that HMGB1 is involved in the dysregulation of primary human brain microvascular endothelial cell junction markers. Our results also indicate that the migration of ZIKV-infected monocytes is dependent on chemokine ligand 19 (CCL19), the natural ligand of CCR7, in conditions recapitulating inflammation. RAGE-dependent migration of ZIKV-infected cells declined during transmigration assays in the presence of RAGE receptor antagonist FPS-ZM1. Understanding the molecular role of monocyte trafficking during ZIKV infections could facilitate the development of new therapeutic strategies to prevent the deleterious consequences of ZIKV neuroinfection.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
de Carvalho GC,Borget MY,Bernier S,Garneau D,da Silva Duarte AJ,Dumais Ndoi
10.1016/j.imbio.2019.08.007subject
Has Abstractpub_date
2019-11-01 00:00:00pages
792-803issue
6eissn
0171-2985issn
1878-3279pii
S0171-2985(19)30183-4journal_volume
224pub_type
杂志文章相关文献
IMMUNOBIOLOGY文献大全abstract：:According to present concepts, innate immunity plays an important role in tumor surveillance and immune modulation. The state of NK cells depends on the balance between inhibitory and activating signals from corresponding receptors. As one of the activating receptors, NKG2D recognises some self ligands such as MICA/B ...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2004.04.008
更新日期：2004-01-01 00:00:00
abstract：:Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2018.07.005
更新日期：2018-11-01 00:00:00
abstract：:Interleukin-6 (IL-6) induced increased, leukocyte and platelet counts on around day 20 when it was administered into [BALB/c-->C3H/He] bone marrow chimeras from day 1 to day 12. Increased leukocyte counts and hemoglobin (Hb) levels were also observed at around day 60 and from day 41 to 80, respectively. On the other h...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(11)80607-8
更新日期：1994-06-01 00:00:00
abstract：:Neopterin is produced in large amounts specifically from macrophages upon stimulation with interferon-gamma (IFN-gamma). Measurement of neopterin allows a direct in vivo quantification of T cell activation. This is particularly useful, e.g., in early diagnosis of graft rejection. Since disease states with elevated neo...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(88)80086-X
更新日期：1988-04-01 00:00:00
abstract：:The goal of our work was to titer the IgG, IgM and IgA in Pentaglobin® (a preparation enriched in IgM), targeting specific surface antigens of Gram-positive and Gram-negative bacteria as well as a C. albicans strain. Lipopolysaccharides from Gram-negative bacteria, peptidoglycan and lipoteichoic acid from the other mi...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2019.12.006
更新日期：2020-03-01 00:00:00
abstract：:The alarming rise of obesity and type 2 diabetes (T2D) has put a tremendous strain on global healthcare systems. Over the past decade extensive research has focused on the role of macrophages as key mediators of inflammation in T2D. The inflammatory environment in the obese adipose tissue and pancreatic β-cell islets ...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2016.08.011
更新日期：2017-10-01 00:00:00
abstract：:Individuals infected with Strongyloides stercoralis have been reported to produce different immunoglobulins isotypes, yet few studies have evaluated their use in strongyloidiasis diagnosis. The aim of this work was to evaluate the immunoreactivity of different classes and subclasses of anti-S. stercoralis circulating ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2019.151898
更新日期：2020-03-01 00:00:00
abstract：:Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain and are found in varying tissues. Ficolins present in sera have a lectin activity toward N-acetylglucosamine through their fibrinogen-like domains. The domain organizations between ficolins and mannose-binding lectin (...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1078/0171-2985-00149
更新日期：2002-09-01 00:00:00
abstract：:Complement component C6 is a part of the lytic membrane attack complex formed during complement activation. Animal modeling to define the role of C5a vs. C5b-9 in human disease has used rodents deficient in C6, yet the molecular basis for the deficiencies has not been ascertained. Oligonucleotides derived from a 493 b...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2004.08.001
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:To investigate the close association between different antiphospholipid antibodies (aPL) caused by infection and their appearance together with a prolonged activated partial thromboplastin time (aPTT). METHODS:Sera from 122 children were evaluated in this study. Thirty-seven children with mild to medium prol...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2005.10.012
更新日期：2005-01-01 00:00:00
abstract：:We have previously generated a murine anti-idiotype (Ab2) monoclonal antibody (mAb) to a murine Ab1 mAb, named P3, which selectively binds Neu-glycolyl (NeuGc)-sialic acid on several monosialo- and disialogangliosides, and also reacts with sulfatides and antigens expressed in human melanoma and breast tumors. This Ab2...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2005.02.002
更新日期：2005-01-01 00:00:00
abstract：:The putative expression of distinct terminally fucosylated glycoconjugates among murine lymphocyte subpopulations was sought using a Biomphalaria alexandrina-derived lectin (BaSI), of proven specificity to a fucosyllactose determinant, and the fucose-binding lectin from Lotus tetragonolobus seeds. Direct labeling of i...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2005.05.023
更新日期：2005-01-01 00:00:00
abstract：:All-trans retinoic acid (ATRA) is a potent retinoid, which has been used successfully in different clinical settings as a potential drug to treat COPD and emphysema. In the present study, we analyzed genes modulated by ATRA by performing mRNA expression array analysis on alveolar macrophages after treatment with ATRA....
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2011.10.022
更新日期：2012-06-01 00:00:00
abstract：:The heavy-chain variable regions (VH) from 14F7 MAb, an IgG1 antibody specific for GM3(NeuGc) ganglioside, and its anti-idiotype, the 4G9 MAb, were cloned and sequenced. Comparison with previously reported sequences showed that VH 14F7 belongs to the J558(VHI) gene family and that it is highly mutated. VH 4G9 belongs ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2006.08.005
更新日期：2007-01-01 00:00:00
abstract：PROBLEM:NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. METHODS OF STUDY:Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present stud...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2013.09.002
更新日期：2014-03-01 00:00:00
abstract：:Cell walls from Streptococcus pyogenes strain Sv (Group A, M type 3) were lysed with M1 endo-N-acetylmuramidase, and the group A-specific carbohydrate antigen was purified by Sephadex G-100 gel filtration. The initial eluting antigen (M1gA) peak was assessed for mitogenic and polyclonal lymphocyte-activating propertie...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/s0171-2985(85)80078-4
更新日期：1985-11-01 00:00:00
abstract：:Respiratory viral infections have been implicated in the origin of, protection from and exacerbation of allergy-related symptoms in a variety of ways. Viral infections are closely linked to infantile wheezing. Severe bronchiolitis in early infancy may predispose to chronic childhood asthma as well as allergic sensitiz...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2007.03.008
更新日期：2007-01-01 00:00:00
abstract：:The major target organ of systemic infection with the intracellular bacterium Listeria monocytogenes is the liver, to where inflammatory leukocytes are rapidly recruited. We determined by reverse transcriptase polymerase chain reaction the early chemokine response in the liver after systemic infection of mice with lis...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(98)80066-1
更新日期：1998-07-01 00:00:00
abstract：:Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activat...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2014.06.006
更新日期：2014-10-01 00:00:00
abstract：:Splenic B cells of BALB/c mice were stimulated in vitro either with lipopolysaccharide (LPS), dextran sulphate (DxS), or with both LPS and DxS. The absolute frequency of B cells that differentiate into clones of immunoglobulin (Ig)-secreting cells upon activation with these mitogens was determined by means of limiting...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/s0171-2985(88)80060-3
更新日期：1988-02-01 00:00:00
abstract：BACKGROUND:The soluble form of the haptoglobin-hemoglobin (Hp-Hb) scavenger receptor (sCD163) is a specific plasma/serum marker for macrophage activity. Here, we have characterized molecular forms in serum and investigated a role of sCD163 as a binder of Hp-Hb complexes. METHODS:The sCD163 species in serum (from 50 he...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2009.05.003
更新日期：2010-05-01 00:00:00
abstract：:The lymphotoxin beta receptor (LTbetaR) mediates crucial signals in host defense against intracellular bacteria and viruses. Mice deficient in LTbetaR readily succumb to infections with Listeria monocytogenes, Mycobacterium tuberculosis and murine cytomegalovirus (mCMV). LTbetaR has been shown to be important for the ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2007.10.011
更新日期：2008-01-01 00:00:00
abstract：:A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3d...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(11)80656-X
更新日期：1992-08-01 00:00:00
abstract：:Dogs infected with Leishmania infantum have a reduced number of T lymphocytes. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family that is expressed by immune cells, and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces the deactivation or apoptosis of T cells. This study aimed to evaluate the expres...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2016.03.007
更新日期：2016-08-01 00:00:00
abstract：:In bitches, the onset of pyometra, an infection of the uterus, characteristically occurs in the first half of the diestrous stage in the estrous cycle, in which the blood concentration of progesterone peaks and that of estradiol-17beta is lowest. To investigate the immunological mechanisms governing stage-specific ons...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2004.09.003
更新日期：2004-01-01 00:00:00
abstract：:We studied immunohistological and biochemical aspects of the CD44 molecule with a mAb produced in our lab: GRHL-1. The characteristic expression of this antigen in cells of B lineage was analyzed. This mAb showed identical immunohistological patterns of reactivity to other mAbs included in CD44 cluster, on a variety l...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(11)80181-6
更新日期：1991-09-01 00:00:00
abstract：:The tumor suppressor protein P53 is strongly involved in orchestrating cellular defenses in the diverse variety of human tissues. Anomalies to lung endothelium permeability are streaming severe consequences towards human health, often associated with fatal outcomes. Ongoing investigations suggest that P53 exerts a pro...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2019.04.008
更新日期：2019-07-01 00:00:00
abstract：:Toll-like receptors (TLR) initiate innate and often affect adaptive immune response. This study aimed to determine if TLR response and T regulatory cell (Treg) function in peripheral blood mononuclear cells (PBMC) correlate with clinical severity in non-infectious asthma. TLR1-9 expression and representative response ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2012.04.002
更新日期：2013-02-01 00:00:00
abstract：:Ficolins and mannan-binding lectin recognize pathogen-associated molecular patterns and initiate the lectin pathway of complement activation via the associated serine proteases. In contrast to human ficolins and mouse ficolin-A, mouse ficolin-B has been considered incapable of complement activation. Dose-dependent bin...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2012.01.013
更新日期：2012-10-01 00:00:00
abstract：:The vitamin D receptor (VDR) is a hormone nuclear receptor regulating bone and calcium homeostasis. Studies revealing the expression of VDR on immune cells point toward a role for VDR-dependent signaling pathways in immunity. Here we verified the ability of the natural VDR ligand, 1,25-dihydroxyvitamin D(3) (1,25(OH)(...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2012.07.018
更新日期：2012-12-01 00:00:00
