当前位置： SCI文献检索 > IMMUNOBIOLOGY期刊下所有文献 > Stronger Toll-like receptor 1/2, 4, and 7/8 but less 9 responses in peripheral blood mononuclear cells in non-infectious exacerbated asthmatic children.

Stronger Toll-like receptor 1/2, 4, and 7/8 but less 9 responses in peripheral blood mononuclear cells in non-infectious exacerbated asthmatic children.

Abstract：

:Toll-like receptors (TLR) initiate innate and often affect adaptive immune response. This study aimed to determine if TLR response and T regulatory cell (Treg) function in peripheral blood mononuclear cells (PBMC) correlate with clinical severity in non-infectious asthma. TLR1-9 expression and representative response cytokine TNF-α, IL-6, and IFN-β secretions were analyzed after stimulation by TLR1-9 ligands from 17 non-infectious asthmatic children. TNF-α production was higher in TLR1/2 (median 385.4 vs. 250.3 pg/ml in 1 μg/ml Pam3CSK4, p=0.0078), TLR4 (2392.4 vs. 1355.9 in 1 μg/ml LPS; p=0.0005), and TLR7/8 (10,776.2 vs. 4237.0 pg/ml in 1 μg/ml R848, p=0.0079) of patients in exacerbation than those in convalescence and healthy controls despite equal TLR expression. TNF-α production stimulated by TLR9 agonist was significantly lower in exacerbation (17.7 vs. 34.9 pg/ml in 1 μg/ml ODN2216, p=0.0175), while IL-6 production had similar patterns but was significantly lower in TLR3 signaling (119.7 vs. 245.0 pg/ml in 0.1 μg/ml poly(I:C), p=0.0033). IFN-β production by TLR3 agonist also decreased in exacerbation but not statistically significant. Six older children showed decreased FOXP3 percentage in CD4+CD25(high) and decreased suppression capability in exacerbation but restored in stabilization (82.8% vs. 90.0%, p=0.0061 and 60.9% vs. 81.7%, p=0.0071; respectively). In conclusion, normalizing imbalanced TLR signaling and enhancing Treg cell capability may guide possible therapeutic strategies for non-infectious asthma in exacerbation.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Lee WI,Yao TC,Yeh KW,Chen LC,Ou LS,Huang JL,PATCH Study Group.

doi

10.1016/j.imbio.2012.04.002

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

192-200

issue

2

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(12)00085-X

journal_volume

218

pub_type

杂志文章

相关文献

IMMUNOBIOLOGY文献大全
  • Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects.

    abstract：:Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2016.07.009

    authors： Bonura A,Vlah S,Longo A,Bulati M,Melis MR,Cibella F,Colombo P

    更新日期：2016-12-01 00:00:00

  • Cell surface-bound urokinase-type plasminogen activator facilitates infiltration of freshly isolated granulocytes into fibrin matrix.

    abstract：:Human cell lines of myelo/monocytic origin express the cellular receptor for urokinase-type plasminogen activator (uPA-R). The receptor localizes urokinase-type plasminogen activator (uPA) to the surface of the cell, where it can convert plasminogen to the active serine proteinase plasmin. Plasmin may subsequently acc...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(11)80104-x

    authors： Herijgers N,Vettel U,Schaefer B,Spring H,Todd RF 3rd,Kramer MD

    更新日期：1995-11-01 00:00:00

  • The diversity of circulating neutrophils in cancer.

    abstract：:Neutrophils, the most abundant leukocyte in human circulation are being more and more recognized as part of the immune reaction to cancer. In the last years, the understanding that neutrophils possess a dual role in cancer development has emerged. During tumor progression the number of neutrophils increase, and their ...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2016.02.001

    authors： Mishalian I,Granot Z,Fridlender ZG

    更新日期：2017-01-01 00:00:00

  • Analyses of H-2 restriction specificity of helper T cells in fully allogeneic bone marrow chimera in mice.

    abstract：:Using irradiation bone marrow chimeras to analyze restriction specificity of helper T cells, we found that recipient H-2 type dictated the H-2 type which the T cells recognize as self (adaptive differentiation). T cells from (H-2b----H-2k) chimeras cooperate with non-T cells bearing Iak to generate a vigorous PFC resp...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(85)80054-1

    authors： Onoé K,Yasumizu R,Noguchi M,Iwabuchi K,Ogasawara M,Kakinuma M,Okuyama H,Good RA,Morikawa K

    更新日期：1985-02-01 00:00:00

  • DAP10 contributes to CD8(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection.

    abstract：:The activating C-type lectin-like receptor NKG2D, which is expressed by mouse NK cells and activated CD8 T cells, was previously demonstrated to be involved in tumor rejection and as a defense mechanism against viral and bacterial infections. Because CD8 T cells are important for protective immune responses during chr...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2010.09.010

    authors： Hessmann M,Rausch A,Rückerl D,Adams PS,Simon M,Gilfillan S,Colonna M,Ehlers S,Hölscher C

    更新日期：2011-05-01 00:00:00

  • The immunosuppressive activities of different cyclosporins are correlated to inhibition of the early membrane phospholipid metabolism in activated lymphocytes.

    abstract：:Recently, it could be shown that Cyclosporin A (CsA) inhibited the activation of T and B lymphocytes by interfering with an early step of the activation, namely the stimulation of the plasma membrane-bound lysophosphatide acyltransferase. In this report, we compared three CsA-derivatives, Dihydro-Cyclosporin C (Dihydr...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(87)80025-6

    authors： Kroggel R,Goppelt-Strübe M,Martin M,Resch K

    更新日期：1987-09-01 00:00:00

  • Modulatory activity of Lactobacillus rhamnosus OLL2838 in a mouse model of intestinal immunopathology.

    abstract：:Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study,...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2015.01.004

    authors： Ogita T,Bergamo P,Maurano F,D'Arienzo R,Mazzarella G,Bozzella G,Luongo D,Sashihara T,Suzuki T,Tanabe S,Rossi M

    更新日期：2015-06-01 00:00:00

  • Polymorphisms of interleukin 6 and interleukin 10 in Egyptian people with Behcet's disease.

    abstract：:Cytokines play critical roles in the pathogenesis of Behçet's disease (BD). They mediated many of the effectors and regulatory functions of immune and inflammatory responses. Many studies have linked Interleukin-6 (IL-6) and Interleukin-10 (IL-10) pathologically to BD. Thus, this study aimed to investigate the associa...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.03.004

    authors： Talaat RM,Ashour ME,Bassyouni IH,Raouf AA

    更新日期：2014-08-01 00:00:00

  • Correlation between effector lymphocytes in natural and antibody-mediated cytotoxicity.

    abstract：:Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxi...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：

    authors： Benczur M,Györffy G,Garam T,Varga M,Medgyesi G,Sándor M,Petranyi GG

    更新日期：1979-09-01 00:00:00

  • Age-related changes of mitogen responsiveness in different lymphoid organs from outbred NMRI mice.

    abstract：:Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(81)80014-9

    authors： Joncourt F,Bettens F,Kristensen F,de Weck AL

    更新日期：1981-06-01 00:00:00

  • Properties of soluble CR2 in human serum.

    abstract：:A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3d...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80656-X

    authors： Ling NR,Brown B

    更新日期：1992-08-01 00:00:00

  • Activation of the first component of complement, C1: comparison of the effect of sixteen different enzymes on serum C1.

    abstract：:In this study, the effect of sixteen different enzymes on serum C1 and its subcomponents was investigated. The sixteen enzymes could be divided into three groups. First, enzymes which activate native C1: trypsin (optimal concentration 2.4 x 10(-4) mM); alpha-chymotrypsin (2.3 x 10(3) mM); thrombin (1.0 x 10(-5) mM); p...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(83)80058-8

    authors： Heinz HP,Loos M

    更新日期：1983-08-01 00:00:00

  • Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells.

    abstract：:In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating e...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2009.10.003

    authors： Boldizsar F,Talaber G,Szabo M,Bartis D,Palinkas L,Nemeth P,Berki T

    更新日期：2010-07-01 00:00:00

  • Mechanisms of interleukin-1beta release.

    abstract：:Interleukin-1beta (IL-1beta) is a potent proinflammatory cytokine that initiates and amplifies a wide variety of effects associated with innate immunity and host responses to microbial invasion and tissue injury. Production and release of IL-1beta are stimulated by either pathogen-associated molecular pattern molecule...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2008.11.007

    authors： Eder C

    更新日期：2009-01-01 00:00:00

  • Activity of acid phosphatase in resting and mitogen-stimulated human peripheral blood lymphocytes.

    abstract：:Activity of acid phosphatase was found to be higher in T than in non-T cells of human peripheral blood lymphocytes. The T cell mitogen PHA induced an increase in the magnitude of acid phosphatase activity, while the B cell mitogen LPS was not able to produce any effect on acid phosphatase activity. Acid phosphatase ac...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(85)80033-4

    authors： Myśliwska J,Myśliwski A,Grzegorzewski K,Witkowski J

    更新日期：1985-03-01 00:00:00

  • Membrane-associated nucleotide pyrophosphatase activity on leucocytes from different compartments.

    abstract：:The distribution of membrane-associated nucleotide pyrophosphatase activity has been investigated on mouse leucocytes of different origin. It is shown that enzyme-specific activity is higher on bone-marrow cells than on cells derived from peripheral organs. Since thymus lymphocytes show the lowest activity, it is obvi...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80029-X

    authors： Brockhaus A,Bösing-Schneider R,Sund H

    更新日期：1982-01-01 00:00:00

  • Studies on the protective efficacy of freeze thawed promastigote antigen of Leishmania donovani along with various adjuvants against visceral leishmaniasis infection in mice.

    abstract：:Visceral leishmaniasis (VL) caused by Leishmania donovani persists as a major public health issue in tropical and subtropical areas of the world. Current treatment of this disease relies on use of drugs. It is doubtful that chemotherapy can alone eradicate the disease, so there is a need for an effective vaccine. Kill...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2015.05.014

    authors： Thakur A,Kaur H,Kaur S

    更新日期：2015-09-01 00:00:00

  • GM-CSF in the generation of dendritic cells from human blood monocyte precursors: recent advances.

    abstract：:Dendritic cells (DCs) play a key role in the orchestration of the immune system by virtue of their capacity to control both immunity and tolerance induction. The functions of DCs depend on the subset as well as their location and activation state. A number of in vitro protocols, developed to recapitulate DC generation...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2008.07.017

    authors： Conti L,Gessani S

    更新日期：2008-01-01 00:00:00

  • Partial characterization of a low molecular weight phagocytosis inhibitory factor obtained from human erythrocyte membranes.

    abstract：:Phagocytosis Inhibitory Factor (PIF), a small (< 3000 D) molecule, was partially purified from human red blood cell membranes. This factor inhibits latex phagocytosis by monocytic cells. PIF is not toxic under the experimental conditions employed and the phagocytosis inhibitory activity is reversible since removal of ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80410-9

    authors： Baranyi L,Baranji K,Yoshida T,Okada N,Okada H

    更新日期：1994-12-01 00:00:00

  • Peripheral blood natural killer cells activation status determined by CD69 upregulation predicts implantation outcome in IVF.

    abstract：PROBLEM:NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. METHODS OF STUDY:Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present stud...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2013.09.002

    authors： Dons'koi BV,Chernyshov VP,Sirenko VY,Strelko GV,Osypchuk DV

    更新日期：2014-03-01 00:00:00

  • Reactive oxygen species (ROS), but not nitric oxide (NO), contribute to strain differences in the susceptibility to experimental arthritis in rats.

    abstract：:There is extensive evidence for the critical role of reactive oxygen species (ROS) and nitric oxide (NO) produced by phagocytes in development of inflammatory processes and pathogenesis of numerous diseases, including rheumatoid arthritis (RA). Apart from their function as mediators of inflammation and tissue damage, ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2006.11.012

    authors： Miletić T,Kovacević-Jovanović V,Vujić V,Stanojević S,Mitić K,Lazarević-Macanović M,Dimitrijević M

    更新日期：2007-01-01 00:00:00

  • Enriched natural killing and antibody-dependent cellular cytotoxicity in lymphocyte populations adherent to tumor cell monolayers.

    abstract：:We have previously shown that human peripheral blood lymphocytes that do not adhere to natural killer (NK)-sensitive target cell monolayers are at least partially depleted of NK activity. To demonstrate directly that NK effector cells adhere to the monolayers, we have now recovered the adherent populations by treatmen...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(82)80052-1

    authors： Jensen PJ,Koren HS

    更新日期：1982-05-01 00:00:00

  • Insights into the immunogenetic basis of two ganglioside-associated idiotypic networks.

    abstract：:The heavy-chain variable regions (VH) from 14F7 MAb, an IgG1 antibody specific for GM3(NeuGc) ganglioside, and its anti-idiotype, the 4G9 MAb, were cloned and sequenced. Comparison with previously reported sequences showed that VH 14F7 belongs to the J558(VHI) gene family and that it is highly mutated. VH 4G9 belongs ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2006.08.005

    authors： Rodríguez M,Roque-Navarro L,López-Requena A,Moreno E,Mateo de Acosta C,Pérez R,María Vázquez A

    更新日期：2007-01-01 00:00:00

  • C1q receptors: regulating specific functions of phagocytic cells.

    abstract：:A C1q receptor that upregulates the phagocytic capacity of professional phagocytes, C1qRp, has been identified, and its primary structure determined by cDNA cloning and sequencing. Monoclonal antibodies that immunoprecipitate this 126,000 Mr polypeptide inhibit the enhancement of phagocytosis triggered not only by C1q...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/S0171-2985(98)80031-4

    authors： Tenner AJ

    更新日期：1998-08-01 00:00:00

  • Characterization and biological effects of recombinant human erythropoietin.

    abstract：:Human recombinant erythropoietin (rHuEPO) has been purified to apparent homogeneity and compared to purified human urinary erythropoietin (EPO). Both the purified natural and recombinant EPO preparations were characterized in a competition radioimmunoassay (RIA), the exhypoxic polycythemic mouse bioassay, in vitro tis...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(86)80101-2

    authors： Egrie JC,Strickland TW,Lane J,Aoki K,Cohen AM,Smalling R,Trail G,Lin FK,Browne JK,Hines DK

    更新日期：1986-09-01 00:00:00

  • Differential effector functions of central and peripheral compartments of immune response system: characterization of immune responses in the spleen and mesenteric lymph nodes to directly injected sheep red blood cells.

    abstract：:When sheep red blood cells (SRBC) were injected intraperitoneally (i.p.), intravenously (i.v.), or into the Peyer's patches, definite plaque-forming cell (PFC) and rosette-forming cell (RFC) responses were induced in the spleen but not in the mesenteric lymph nodes (MLN). When SRBC were injected directly into the sple...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(82)80047-8

    authors： Kojima T,Kamei H,Kondo T,Nakashima I,Kato N

    更新日期：1982-05-01 00:00:00

  • Immunomodulatory effects of myeloid-derived suppressor cells in diseases: Role in cancer and infections.

    abstract：:Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells capable of abrogating T and B cells responses and have been identified in numerous cancers. As with other regulatory cell populations, they aim to maintain balance between host-defence-associated inflammation and ensuing tissue pathology. MDSC accumulati...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2017.07.001

    authors： Tamadaho RSE,Hoerauf A,Layland LE

    更新日期：2018-01-01 00:00:00

  • NK cells modulate MHC class I expression on tumor cells and their susceptibility to lysis.

    abstract：:Cytotoxicity and production of cytokines are two important functions of NK cells. These two different NK functions were studied in a syngeneic rat model in relation to MHC class I expression. We focussed on the mechanism by which NK cells modulate MHC class I expression on target cells and how this interferes with NK ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(00)80037-6

    authors： Jonges LE,Giezeman-Smits KM,van Vlierberghe RL,Ensink NG,Hagenaars M,Joly E,Eggermont AM,van de Velde CJ,Fleuren GJ,Kuppen PJ

    更新日期：2000-11-01 00:00:00

  • Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia.

    abstract：:Regulatory properties of macrophages associated with alternative activation serve to limit the exaggerated inflammatory response during pneumonia caused by Pseudomonas aeruginosa infection. Arginase-1 is an important effector of these macrophages believed to play an essential role in decreasing injury and promoting re...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2020.152034

    authors： Haydar D,Gonzalez R,Garvy BA,Garneau-Tsodikova S,Thamban Chandrika N,Bocklage TJ,Feola DJ

    更新日期：2020-11-24 00:00:00

  • UL16 binding proteins.

    abstract：:According to present concepts, innate immunity plays an important role in tumor surveillance and immune modulation. The state of NK cells depends on the balance between inhibitory and activating signals from corresponding receptors. As one of the activating receptors, NKG2D recognises some self ligands such as MICA/B ...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2004.04.008

    authors： Cao W,He W

    更新日期：2004-01-01 00:00:00