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Peripheral blood natural killer cells activation status determined by CD69 upregulation predicts implantation outcome in IVF.

Abstract：

PROBLEM:NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. METHODS OF STUDY:Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present study, we investigate the significance of NK activation levels in predicting embryo implantation. RESULTS:A qualitative analysis of values distribution in two groups showed that 25/33 (75.8%) women who became pregnant had CD69(stim) levels that were >30 but <60% (conditionally normal zone). In contrast, CD69(stim) levels in patients who failed to become pregnant were either elevated, as in 10/51 (19.6%), or reduced, as in 20/51 (39.2%) of the patients. Accentuated CD69(stim) levels were predictive for implantation failure, extremely significant for decreased (OR 6.9, p=0.0004) and not quite significant for increased CD69(stim) levels (OR 3.9, p=0.062). Accordingly, conditionally normal CD69(stim) levels were favourable for implantation (OR 4.46, p=0.0032). CONCLUSION:We confirm that actual peripheral blood natural killer cells activation status have an influence on embryo implantation. We showed that exactly normal NK cell activity predicting successful implantation.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Dons'koi BV,Chernyshov VP,Sirenko VY,Strelko GV,Osypchuk DV

doi

10.1016/j.imbio.2013.09.002

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

167-71

issue

3

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(13)00165-4

journal_volume

219

pub_type

杂志文章

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