当前位置： SCI文献检索 > IMMUNOBIOLOGY期刊下所有文献 > The role of nucleotide-binding oligomerization domain 1 during cytokine production by macrophages in response to Mycobacterium tuberculosis infection.

The role of nucleotide-binding oligomerization domain 1 during cytokine production by macrophages in response to Mycobacterium tuberculosis infection.

Abstract：

:Tuberculosis due to Mycobacterium tuberculosis infection is a leading cause of death worldwide. Recognition of this pathogen is crucial for the activation of innate and adaptive immune responses. Nucleotide-binding oligomerization domain (Nod)1 and Nod2 are cytoplasmic receptors that can detect unique muropeptides of bacterial peptidoglycan. Nod2 is critical for the initiation of the host immune response against M. tuberculosis infection, however the role of Nod1 remains largely unknown. We investigated the role of Nod1 with respect to cytokine production by bone marrow-derived macrophages (BMDMs) in response to M. tuberculosis infection. Production of proinflammatory cytokines, such as IL-6, TNF-α, and IL-1β were induced in BMDMs; cytokine levels were not affected by a deficiency in Nod1. Activation of NF-κB and MAPKs was also comparable between wild-type and Nod1-deficient BMDMs. Levels of IL-6 and IL-1β were reduced in Nod1/Nod2 double-deficient BMDMs to a greater extent than in Nod2-deficient cells. Furthermore, when signaling of Toll-like receptors (TLRs) was inhibited by lipopolysaccharide pre-treatment, cytokine production was diminished in Nod1-deficient BMDMs. Our results indicate that Nod1 cooperates with Nod2 or TLRs to produce cytokines in macrophages in response to M. tuberculosis infection.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Lee JY,Hwang EH,Kim DJ,Oh SM,Lee KB,Shin SJ,Park JH

doi

10.1016/j.imbio.2015.07.020

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

70-5

issue

1

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(15)30039-5

journal_volume

221

pub_type

杂志文章

相关文献

IMMUNOBIOLOGY文献大全
  • Multidirectional interactions in vitro between lymphoid cells from Mls-disparate strains.

    abstract：:Chromosome 1 of the mouse carries a number of genes for alloantigens which can be recognized by T cells, among those the mixed lymphocyte stimulation (Mls) locus and the lymphocyte stimulating determinant (Lsd) locus have been described. The Relationship between the antigens coded for by these two loci has been furthe...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(88)80037-8

    authors： Goldbach J,Prahl H,Stäb F,Steinhausen D,Kölsch E

    更新日期：1988-05-01 00:00:00

  • Stimulation of human and mouse lymphocytes by ribosomal proteins.

    abstract：:Ribosomal 30S and 50S subunits as well as total proteins from the large subunit of E. coli ribosomes were found to be potent mitogens for both human adult and cord blood lymphocytes. On the other hand, the RNA fraction of the 50S subunit had only a weak stimulatory capacity suggesting that the protein moiety contains ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(80)80079-9

    authors： Sieber G,Rühl H

    更新日期：1980-01-01 00:00:00

  • Caffeine: Well-known as psychotropic substance, but little as immunomodulator.

    abstract：:To date, numerable reviews are found in the literature prominent to the effect of caffeine on the immune system, with the latest review published in 2006. Database screening reveals around three thousand articles that have been published during the last decade. Interestingly, less than hundred articles involved humans...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2018.08.011

    authors： Al Reef T,Ghanem E

    更新日期：2018-12-01 00:00:00

  • IL-13 attenuates early local CXCL2-dependent neutrophil recruitment for Candida albicans clearance during a severe murine systemic infection.

    abstract：:To investigate the role of IL-13 during a severe systemic Candida albicans infection, BALB/c control and IL-13-/- mice were examined for colony forming units (CFU) in the kidneys and survival days after intravenous infection. Proinflammatory mediators and cell recruitment into the tissue were measured by quantitative ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2018.11.002

    authors： Abe Y,Yamamoto N,Nakamura K,Arai K,Sakurai C,Hatsuzawa K,Ogura Y,Iseki K,Tase C,Kanemitsu K

    更新日期：2019-01-01 00:00:00

  • Treatment of metastatic malignant melanoma with recombinant interferon alpha 2.

    abstract：:Fifty-nine patients with metastatic malignant melanoma were entered into a phase II trial of recombinant alpha-2 interferon given in a dosage of 10 million IU/M2 subcutaneously three times per week for one year. Forty-five of these were evaluable for response. Of five evaluable patients with ocular primaries, none res...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(86)80109-7

    authors： Robinson WA,Mughal TI,Thomas MR,Johnson M,Spiegel RJ

    更新日期：1986-09-01 00:00:00

  • Lung function and inflammation during murine Pseudomonas aeruginosa airway infection.

    abstract：BACKGROUND:Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs. OBJECTIVES:The present study investigates the association between immune response and decline in lung function...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2011.02.003

    authors： Wölbeling F,Munder A,Kerber-Momot T,Neumann D,Hennig C,Hansen G,Tümmler B,Baumann U

    更新日期：2011-08-01 00:00:00

  • Isolation of HLA-haplotype-specific human T-lymphocyte clones.

    abstract：:Human T-lymphocyte clones showing proliferative and cytotoxic responses specific for HLA antigens were isolated. To obtain enriched numbers of functionally active colonies, the cells were first sensitized in vitro in a tertiary mixed lymphocyte culture (MLC), using 10 stimulating cells for each responding cell. To ass...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(81)80062-9

    authors： Schendel DJ,Wank R

    更新日期：1981-01-01 00:00:00

  • Cell wall preparation consisting of group A carbohydrate and peptidoglycan moieties from Streptococcus pyogenes activates murine B lymphocytes.

    abstract：:Cell walls from Streptococcus pyogenes strain Sv (Group A, M type 3) were lysed with M1 endo-N-acetylmuramidase, and the group A-specific carbohydrate antigen was purified by Sephadex G-100 gel filtration. The initial eluting antigen (M1gA) peak was assessed for mitogenic and polyclonal lymphocyte-activating propertie...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(85)80078-4

    authors： Morisaki I,Kimura S,Torii M,Michalek SM,McGhee JR,Okahashi N,Hamada S

    更新日期：1985-11-01 00:00:00

  • Variation in complement component C1 inhibitor in age-related macular degeneration.

    abstract：:This study assessed variation in plasma levels of the complement regulatorC1 inhibitor (C1inh) in patients with age related macular degeneration (AMD) and controls. Plasma from391 AMD cases and 370 controls was assayed by rate nephelometry to determine C1inh protein levels. Protein levels were analysed for relationshi...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2011.07.015

    authors： Gibson J,Hakobyan S,Cree AJ,Collins A,Harris CL,Ennis S,Morgan BP,Lotery AJ

    更新日期：2012-02-01 00:00:00

  • Insights into the immunogenetic basis of two ganglioside-associated idiotypic networks.

    abstract：:The heavy-chain variable regions (VH) from 14F7 MAb, an IgG1 antibody specific for GM3(NeuGc) ganglioside, and its anti-idiotype, the 4G9 MAb, were cloned and sequenced. Comparison with previously reported sequences showed that VH 14F7 belongs to the J558(VHI) gene family and that it is highly mutated. VH 4G9 belongs ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2006.08.005

    authors： Rodríguez M,Roque-Navarro L,López-Requena A,Moreno E,Mateo de Acosta C,Pérez R,María Vázquez A

    更新日期：2007-01-01 00:00:00

  • Hyperreactivity of adult BALB/c mice tolerized at birth with TNP-ovalbumin.

    abstract：:BALB/c mice injected with 0.2 mg TNP-ovalbumin (OA) within 24 hours after birth showed reduced levels of functionally active TNP-specific B cells and, accordingly, of plaque-forming cells (PFC) after challenge with carrier-bound TNP until the age of 8 weeks. Yet, when B cells of tolerized mice were cultured in the abs...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(87)80105-5

    authors： Zöller M,Andrighetto G

    更新日期：1987-12-01 00:00:00

  • Age-related changes of mitogen responsiveness in different lymphoid organs from outbred NMRI mice.

    abstract：:Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(81)80014-9

    authors： Joncourt F,Bettens F,Kristensen F,de Weck AL

    更新日期：1981-06-01 00:00:00

  • Psoriatic inflammation causes hepatic inflammation with concomitant dysregulation in hepatic metabolism via IL-17A/IL-17 receptor signaling in a murine model.

    abstract：:Psoriatic inflammation has been shown to be associated with cardiovascular dysfunction and systemic inflammation. Recently, psoriasis has also been linked to hepatic disorders, however underlying mechanism connecting the two are unknown. IL-17A being a central pro-inflammatory cytokine in the pathogenesis of psoriasis...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2016.10.013

    authors： Al-Harbi NO,Nadeem A,Al-Harbi MM,Zoheir KMA,Ansari MA,El-Sherbeeny AM,Alanazi KM,Alotaibi MR,Ahmad SF

    更新日期：2017-02-01 00:00:00

  • Immunomodulatory effects of myeloid-derived suppressor cells in diseases: Role in cancer and infections.

    abstract：:Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells capable of abrogating T and B cells responses and have been identified in numerous cancers. As with other regulatory cell populations, they aim to maintain balance between host-defence-associated inflammation and ensuing tissue pathology. MDSC accumulati...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2017.07.001

    authors： Tamadaho RSE,Hoerauf A,Layland LE

    更新日期：2018-01-01 00:00:00

  • Modulation by adherent cells and irradiation of in vitro LIF production by Con-A stimulated mononuclear cells.

    abstract：:LIF activity production by ConA-stimulated mononuclear cells was tested by measuring granulocyte migration from clotted plasma droplets placed in Microtest II plates. 90 min. incubation of MNC cultures with ConA assured a significant LIF activity in the 24 h. culture supernatants. Removal of the adherent cells after C...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(81)80097-6

    authors： Sandru G,Veraguth P

    更新日期：1981-01-01 00:00:00

  • Structure, function and molecular genetics of human and murine C1r.

    abstract：:C1r, the enzyme responsible for intrinsic activation of the C1 complex of complement, is a modular serine protease featuring an overall structural organization homologous to those of C1s and the mannan-binding lectin-associated serine proteases (MASPs). This review will initially summarize current information on the s...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1078/0171-2985-00139

    authors： Arlaud GJ,Gaboriaud C,Garnier G,Circolo A,Thielens NM,Budayova-Spano M,Fontecilla-Camps JC,Volanakis JE

    更新日期：2002-09-01 00:00:00

  • Mucosal and systemic anti-GAG immunity induced by neonatal immunization with HIV LAMP/gag DNA vaccine in mice.

    abstract：:Vaccines capable of inducing mucosal immunity in early postnatal life until adulthood, protecting early sexual initiation, should be considered as strategies to vaccination against HIV. The HIV-1 GAG protein as a chimera with the lysosome-associated membrane protein (LAMP/gag), encoded by a DNA vaccine, is targeted to...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2010.08.007

    authors： Goldoni AL,Maciel M Jr,Rigato PO,Piubelli O,de Brito CA,Melo A,Marques ET,August JT,Duarte AJ,Sato MN

    更新日期：2011-04-01 00:00:00

  • Anomalies in the dominant sarcoidosis paradigm justify its displacement.

    abstract：:The prevailing paradigm defines sarcoidosis as a disease of unknown etiology characterized by a systemic noncaseating epithelioid granulomatous response (SGR). This formulation fails to account for the elusiveness of the etiological agent, the nature of the Kveim response, the paradox of cutaneous delayed type hyperse...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2016.12.005

    authors： Reich JM

    更新日期：2017-04-01 00:00:00

  • Anti-citrullinated protein antibodies suppress let-7a expression in monocytes from patients with rheumatoid arthritis and facilitate the inflammatory responses in rheumatoid arthritis.

    abstract：:We hypothesized that anti-citrullinated protein antibodies (ACPAs) could affect the expression of miRNAs in monocytes and contribute to the inflammatory responses in rheumatoid arthritis (RA). The expression profiles of 270 human miRNAs, co-cultured with ACPAs or human immunoglobulin G (IgG), were analyzed using real-...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2015.07.007

    authors： Lai NS,Yu HC,Yu CL,Koo M,Huang HB,Lu MC

    更新日期：2015-12-01 00:00:00

  • Involvement of CD28 cosignalling in the T cell-mediated suppression of the IgG antibody response against the TI-2 antigen alpha(1-->3) dextran.

    abstract：:The humoral immune response against alpha(1-->3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals, however, the response proceeds to a vigorous IgG production. In euthymic mice for...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(99)80046-1

    authors： Specht C,Junker R,Krüger A,Rademaekers A,Redlich H,Kölsch E

    更新日期：1999-09-01 00:00:00

  • The effects of increased heme oxygenase-1 on the lymphoproliferative response in dogs with visceral leishmaniasis.

    abstract：:Canine visceral leishmaniasis (CVL) is known to affect the cellular immunity of infected dogs, through impairing lymphoproliferation and microbicidal mechanisms. This study examined heme oxygenase-1 (HO-1) and its metabolites, oxidative stress and IL-10 levels in CVL and investigated correlations between these paramet...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2016.12.006

    authors： Almeida BF,Silva KL,Chiku VM,Leal AA,Venturin GL,Narciso LG,Fink MF,Eugênio FR,Santos PS,Ciarlini PC,Lima VM

    更新日期：2017-05-01 00:00:00

  • 1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism.

    abstract：:The vitamin D receptor (VDR) is a hormone nuclear receptor regulating bone and calcium homeostasis. Studies revealing the expression of VDR on immune cells point toward a role for VDR-dependent signaling pathways in immunity. Here we verified the ability of the natural VDR ligand, 1,25-dihydroxyvitamin D(3) (1,25(OH)(...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2012.07.018

    authors： Korf H,Wenes M,Stijlemans B,Takiishi T,Robert S,Miani M,Eizirik DL,Gysemans C,Mathieu C

    更新日期：2012-12-01 00:00:00

  • Tumor transfected with CCL21 enhanced reactivity and apoptosis resistance of human monocyte-derived dendritic cells.

    abstract：:Chemokine CCL21 can effectively attract CCR7(+) dendritic cells (DCs), however its role in this event is poorly understood. In this report, we investigated the effect of exogenous CCL21 expressed in breast cancer MCF-7 on human monocyte-derived DCs. CCL21-transfected MCF-7 stimulation prompted DC functions: migration,...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2007.10.003

    authors： Wu S,Xing W,Peng J,Yuan X,Zhao X,Lei P,Li W,Wang M,Zhu H,Huang B,Huang L,Shen G

    更新日期：2008-01-01 00:00:00

  • Correlation between effector lymphocytes in natural and antibody-mediated cytotoxicity.

    abstract：:Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxi...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：

    authors： Benczur M,Györffy G,Garam T,Varga M,Medgyesi G,Sándor M,Petranyi GG

    更新日期：1979-09-01 00:00:00

  • Murine CD83-positive T cells mediate suppressor functions in vitro and in vivo.

    abstract：:The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25, cytotoxic T lymphoc...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.08.005

    authors： Kreiser S,Eckhardt J,Kuhnt C,Stein M,Krzyzak L,Seitz C,Tucher C,Knippertz I,Becker C,Günther C,Steinkasserer A,Lechmann M

    更新日期：2015-02-01 00:00:00

  • Analyses of H-2 restriction specificity of helper T cells in fully allogeneic bone marrow chimera in mice.

    abstract：:Using irradiation bone marrow chimeras to analyze restriction specificity of helper T cells, we found that recipient H-2 type dictated the H-2 type which the T cells recognize as self (adaptive differentiation). T cells from (H-2b----H-2k) chimeras cooperate with non-T cells bearing Iak to generate a vigorous PFC resp...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(85)80054-1

    authors： Onoé K,Yasumizu R,Noguchi M,Iwabuchi K,Ogasawara M,Kakinuma M,Okuyama H,Good RA,Morikawa K

    更新日期：1985-02-01 00:00:00

  • Comparative analysis of the internalization of the macrophage receptor sialoadhesin in human and mouse primary macrophages and cell lines.

    abstract：:Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2016.11.013

    authors： De Schryver M,Leemans A,Pintelon I,Cappoen D,Maes L,Caljon G,Cos P,Delputte PL

    更新日期：2017-06-01 00:00:00

  • Positive association of Bx genotype, KIR2L5, KIR2DS5 and full-length KIR2DS4 with the risk of meningioma.

    abstract：BACKGROUND:NK cells as a part of innate immune system, are controlled by a set of activating and inhibitory KIR receptors (aKIR, iKIR) which are implicated in tumor microenvironment immunity through a variety of activating and inhibitory immune signals. KIRs are multi gene family receptors that differ in the number and...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2019.151900

    authors： Barani S,Taghipour M,Ghaderi A

    更新日期：2020-03-01 00:00:00

  • NLRC5 polymorphism is associated with susceptibility to chronic periodontitis.

    abstract：:Periodontitis is a chronic oral pathology caused by impaired immune response against oral bacteria resulting in tissue inflammation and damage. Among the members of innate immune response, the first line of defence against pathogens, inflammasomes are macro-molecular protein complexes that can be activated by differen...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2017.01.001

    authors： Zupin L,Navarra CO,Robino A,Bevilacqua L,Di Lenarda R,Gasparini P,Crovella S

    更新日期：2017-05-01 00:00:00

  • Lectin complement system and pattern recognition.

    abstract：:Living organisms have strong defense mechanisms against invading microorganisms as survival strategies. One of the defense mechanisms is the complement system, composed of more than 30 serum and cell surface components. This system collaborates in recognition and elimination of pathogens as a part of both the innate a...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2006.01.003

    authors： Endo Y,Takahashi M,Fujita T

    更新日期：2006-01-01 00:00:00