Modulation by adherent cells and irradiation of in vitro LIF production by Con-A stimulated mononuclear cells.

abstract：:Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxi...

journal_title：Immunobiology

authors： Benczur M,Györffy G,Garam T,Varga M,Medgyesi G,Sándor M,Petranyi GG

更新日期：1979-09-01 00:00:00

abstract：:Considering that imbalance of central tolerance in the thymus contributes to aggressive autoimmunity, we compared the expression of peripheral tissue autoantigens (PTA) genes, which are involved in self-representation in the thymic stroma, of two mouse strains; DBA-1/J (MHC-H2(q)) susceptible and DBA-2/J (MHC-H2(d)) r...

journal_title：Immunobiology

authors： Donate PB,Fornari TA,Junta CM,Magalhães DA,Macedo C,Cunha TM,Nguyen C,Cunha FQ,Passos GA

更新日期：2011-05-01 00:00:00

abstract：:In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating e...

journal_title：Immunobiology

authors： Boldizsar F,Talaber G,Szabo M,Bartis D,Palinkas L,Nemeth P,Berki T

更新日期：2010-07-01 00:00:00

abstract：:Respiratory viral infections have been implicated in the origin of, protection from and exacerbation of allergy-related symptoms in a variety of ways. Viral infections are closely linked to infantile wheezing. Severe bronchiolitis in early infancy may predispose to chronic childhood asthma as well as allergic sensitiz...

journal_title：Immunobiology

authors： Xepapadaki P,Papadopoulos NG

更新日期：2007-01-01 00:00:00

abstract：:People deficient in C1-INH present recurrent angioedema localized to subcutaneous or mucous tissues. The defect can be caused by impaired synthesis, due to a genetic defect (hereditary angioedema), or by increased catabolism (acquired angioedema). In our experience the majority of patients with acquired angioedema (16...

journal_title：Immunobiology

authors： Cicardi M,Bergamaschini L,Cugno M,Beretta A,Zingale LC,Colombo M,Agostoni A

更新日期：1998-08-01 00:00:00

abstract：:Regulatory properties of macrophages associated with alternative activation serve to limit the exaggerated inflammatory response during pneumonia caused by Pseudomonas aeruginosa infection. Arginase-1 is an important effector of these macrophages believed to play an essential role in decreasing injury and promoting re...

journal_title：Immunobiology

authors： Haydar D,Gonzalez R,Garvy BA,Garneau-Tsodikova S,Thamban Chandrika N,Bocklage TJ,Feola DJ

更新日期：2020-11-24 00:00:00

abstract：:The collectins are a group of innate immune proteins structurally characterized by their content of a carbohydrate recognition domain and a collagen-like region. Collectin liver 1 (CL-L1) and collectin 11 (CL-11, alias collectin kidney 1, CL-K1) are the more recently described members of this group. Their genomic orga...

journal_title：Immunobiology

authors： Selman L,Hansen S

更新日期：2012-09-01 00:00:00

abstract：:Alternative macrophage activation is largely defined by IL-4Rα stimulation but the contribution of Toll-like receptor (TLR) signaling to this phenotype is not currently known. We have investigated macrophage activation status under Th2 conditions in the absence of the core TLR adaptor molecule, MyD88. No impairment wa...

journal_title：Immunobiology

authors： Mylonas KJ,Hoeve MA,MacDonald AS,Allen JE

更新日期：2013-04-01 00:00:00

abstract：:The process of thymopoiesis is tightly regulated by a series of selection events which ensure that only functional T-lymphocytes directed against foreign antigens are exported into the periphery. The adaptive immune response largely depends on the regulation of thymocyte development, and thymocytes which fail selectio...

journal_title：Immunobiology

authors： Hutcheson J,Perlman H

更新日期：2007-01-01 00:00:00

abstract：:The expansion of effector T cells is tightly controlled by transcription factors like nuclear factor of activated T cells (NFAT) family members that mediate early intracellular responses to T cell receptor-mediated signals. In this study we show that, after allergen challenge, NFATc2((-/-)) mice had augmented number o...

journal_title：Immunobiology

authors： Karwot R,Übel C,Bopp T,Schmitt E,Finotto S

更新日期：2012-09-01 00:00:00

abstract：:Fifty-nine patients with metastatic malignant melanoma were entered into a phase II trial of recombinant alpha-2 interferon given in a dosage of 10 million IU/M2 subcutaneously three times per week for one year. Forty-five of these were evaluable for response. Of five evaluable patients with ocular primaries, none res...

journal_title：Immunobiology

authors： Robinson WA,Mughal TI,Thomas MR,Johnson M,Spiegel RJ

更新日期：1986-09-01 00:00:00

abstract：:C1q binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. C1q binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology o...

journal_title：Immunobiology

authors： Sim RB,Kishore U,Villiers CL,Marche PN,Mitchell DA

更新日期：2007-01-01 00:00:00

abstract：:Details of the "Trojan Horse" mechanism by which Zika virus (ZIKV) crosses the blood-brain barrier (BBB) remain unclear. However, the migration of ZIKV-infected monocytes to the brain is thought to be dependent on both pattern-recognition and chemokine receptors. In this study, we investigated whether the migration of...

journal_title：Immunobiology

authors： de Carvalho GC,Borget MY,Bernier S,Garneau D,da Silva Duarte AJ,Dumais N

更新日期：2019-11-01 00:00:00

abstract：:We investigated the mRNA expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in human T cell lymphotropic virus type I (HTLV-I) p40tax-transfected U937 cells, a human monoblast cell line. Transfection of HTLV-I p40tax U937 cells induced up-regulation of iNOS mRNA expression and...

journal_title：Immunobiology

authors： Goto H,Nakamura T,Shirabe S,Ueki Y,Nishiura Y,Furuya T,Tsujino A,Nakane S,Eguchi K,Nagataki S

更新日期：1997-11-01 00:00:00

abstract：:Cell walls from Streptococcus pyogenes strain Sv (Group A, M type 3) were lysed with M1 endo-N-acetylmuramidase, and the group A-specific carbohydrate antigen was purified by Sephadex G-100 gel filtration. The initial eluting antigen (M1gA) peak was assessed for mitogenic and polyclonal lymphocyte-activating propertie...

journal_title：Immunobiology

authors： Morisaki I,Kimura S,Torii M,Michalek SM,McGhee JR,Okahashi N,Hamada S

更新日期：1985-11-01 00:00:00

abstract：:Asthma is characterized by inflammation, pulmonary remodeling and bronchial hyperresponsiveness. We have previously shown that treatment with angiotensin-(1-7) [Ang-(1-7)] promotes resolution of eosinophilic inflammation and prevents chronic allergic lung inflammation. Here, we evaluated the effect of treatment with t...

journal_title：Immunobiology

authors： Magalhães GS,Gregório JF,Ramos KE,Cançado-Ribeiro ATP,Baroni IF,Barcelos LS,Pinho V,Teixeira MM,Santos RAS,Rodrigues-Machado MG,Campagnole-Santos MJ

更新日期：2020-05-01 00:00:00

abstract：:Toll-like receptors (TLR) initiate innate and often affect adaptive immune response. This study aimed to determine if TLR response and T regulatory cell (Treg) function in peripheral blood mononuclear cells (PBMC) correlate with clinical severity in non-infectious asthma. TLR1-9 expression and representative response ...

journal_title：Immunobiology

authors： Lee WI,Yao TC,Yeh KW,Chen LC,Ou LS,Huang JL,PATCH Study Group.

更新日期：2013-02-01 00:00:00

abstract：:Gammaherpesviruses (gammaHV) establish a life-long latency in the host and are associated with a number of malignant human diseases. It is generally believed that T cells play a major role in controlling the initial acute infection and subsequently maintaining the virus in a quiescent state. However, the nature of the...

journal_title：Immunobiology

authors： Woodland DL,Flaño E,Usherwood EJ,Liu Luzheng,Kim IJ,Husain SM,Sample JT,Blackman MA

更新日期：2001-12-01 00:00:00

abstract：:Bone marrow-derived macrophages (BMM) comprise a population of quiescent cells which can be activated by defined signals. Here, we directly compare the release of chemokines and monokines by BMM raised either in serum-supplemented or in serum-free medium in response to Listeria monocytogenes EGD or Mycobacterium bovis...

journal_title：Immunobiology

authors： Flesch IE,Kaufmann SH

更新日期：1999-02-01 00:00:00

abstract：:Pregnancy is known to induce a transient depression of maternal cell-mediated immunity, to prevent rejection of the fetus, while at the same time it keeps adequate maternal host defense mechanisms to fight infection. Presently, the aim of this paper was to investigate a possible endocrine and immunologic alteration ob...

journal_title：Immunobiology

authors： Brazão V,Kuehn CC,dos Santos CD,da Costa CM,Júnior JC,Carraro-Abrahão AA

更新日期：2015-01-01 00:00:00

abstract：:Infection of human monocytes with influenza A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis. The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorl...

journal_title：Immunobiology

authors： Bussfeld D,Bacher M,Moritz A,Gemsa D,Sprenger H

更新日期：1997-12-01 00:00:00

abstract：:Acute lung injury (ALI) is an acute inflammatory disorder. Toll-like receptor-4 (TLR-4) and Stanniocalcin -1 (STC-1) had roles in lung endothelial protection. This study aims to assess TLR-4 and SCT-1 genes expressions in peripheral blood of ALI patients. Total RNA was extracted from peripheral blood of 48 subjects (2...

journal_title：Immunobiology

authors： Esawy MM,Shabana MA,Baioumy SA,Ismail NA

更新日期：2019-11-01 00:00:00

abstract：:"Brucelline INRA" is an aqueous extract of a rough strain of Brucella melitensis that is used to test cutaneous delayed hypersensitivity in man and animals. The cellular response of mice (either normal, or sensitized by a previous brucella infection) was investigated with local implanted "cell-traps" and by immunologi...

journal_title：Immunobiology

authors： Bureau JP,Caravano R,Garelli L,Lemaire J

更新日期：1989-03-01 00:00:00

abstract：CONTEXT:The PDS gene (SLC26A4) is responsible for Pendred syndrome (PS). Genetic analysis of PDS using Tunisian samples showed evidence for linkage and association with autoimmune thyroid diseases (AITD) emergence. In addition, the PDS gene product, pendrin, was recently identified as a novel autoantigen in Graves' dis...

journal_title：Immunobiology

authors： Belguith-Maalej S,Rebuffat SA,Charfeddine I,Mnif M,Nadir RF,Abid M,Ghorbel A,Peraldi-Roux S,Ayadi H,Hadj-Kacem H

更新日期：2011-05-01 00:00:00

abstract：:The mechanisms that mediate accelerated atherosclerosis in autoimmune diseases remain unclear. One common mechanism that has been documented in autoimmune diseases and atherosclerosis is formation of hypoglycosyalted N-glycans on the cell surface. In this study we tested the effects of swainsonine, a class II α-mannos...

journal_title：Immunobiology

authors： Scott DW,Black LL,Vallejo MO,Kabarowski JH,Patel RP

更新日期：2014-07-01 00:00:00

abstract：:Guinea pig (gp) platelets react to nanomolar doses of the complement-derived anaphylatoxin C5a with a shape change, aggregation and release of biogenic amines and nucleotides from their granules. We have investigated the specific receptor for C5a on gp platelets which mediates these biological effects. Competitive bin...

journal_title：Immunobiology

authors： Kretzschmar T,Kahl K,Rech K,Bautsch W,Köhl J,Bitter-Suermann D

更新日期：1991-11-01 00:00:00

abstract：INTRODUCTION:Fexofenadine (FXF) is a third-generation antihistamine drug and osthole is assumed as a natural antihistamine alternative. This paper compares results of histamine, FXF and osthole impact on HRH-1, COX-2, NF-κB-p50, CCR1 mRNA expression. We also measured mRNA expression of IL-1β and CCL5/RANTES in incubate...

journal_title：Immunobiology

authors： Kordulewska NK,Kostyra E,Cieślińska A,Matysiewicz M,Fiedorowicz E,Sienkiewicz-Szłapka E

更新日期：2017-03-01 00:00:00

abstract：:Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study,...

journal_title：Immunobiology

authors： Ogita T,Bergamo P,Maurano F,D'Arienzo R,Mazzarella G,Bozzella G,Luongo D,Sashihara T,Suzuki T,Tanabe S,Rossi M

更新日期：2015-06-01 00:00:00

abstract：:The century-old tuberculosis vaccine BCG has been the focus of renewed interest due to its well-documented ability to protect against various non-TB pathogens. Much of these broad spectrum protective effects are attributed to trained immunity, the epigenetic and metabolic reprogramming of innate immune cells. As BCG v...

journal_title：Immunobiology

authors： Moulson AJ,Av-Gay Y

更新日期：2020-12-24 00:00:00

abstract：:Peritoneal exudate T lymphocytes (PETLs) that mediate delayed-type hypersensitivity (DTH) to sheep red blood cells in mice were modified by in vitro treatment methods which modify surface carbohydrate constituents. Neuraminidase treatment resulted in the release of both N-acetylneuraminic acid and N-glycolyl-neuramini...

journal_title：Immunobiology

authors： Kaufmann SH,Schauer R,Hahn H

更新日期：1981-01-01 00:00:00