当前位置： SCI文献检索 > IMMUNOBIOLOGY期刊下所有文献 > Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients.

Changes in gene expression induced by histamine, fexofenadine and osthole: Expression of histamine H1 receptor, COX-2, NF-κB, CCR1, chemokine CCL5/RANTES and interleukin-1β in PBMC allergic and non-allergic patients.

Abstract：

INTRODUCTION:Fexofenadine (FXF) is a third-generation antihistamine drug and osthole is assumed as a natural antihistamine alternative. This paper compares results of histamine, FXF and osthole impact on HRH-1, COX-2, NF-κB-p50, CCR1 mRNA expression. We also measured mRNA expression of IL-1β and CCL5/RANTES in incubated peripheral blood mononuclear cells (PBMC) to compared how histamine, FXF and osthole had influence on expression level and interacts on product secretion. OBJECTIVE:The purpose was to investigate expression pattern in asthma PBMC. METHODS:The cultures were treated 72h with FXF and osthole. We measured mRNA expression of histamine HRH-1, COX-2, NF-κB-p50, CCR1, IL-1β and CCL5/RANTES with Real-Time PCR (RT-PCR). RESULTS:The present study suggest that osthole may be a potential inhibitor of histamine H1 receptor activity. We also demonstrated that cells cultured with histamine increase COX-2 mRNA expression and osthole reduce it. CONCLUSION:Allergy remains one of the most common chronic diseases in Europe and it is rapidly approaching epidemic proportions; with current predictions estimating that the number of allergy-afflicted will equal the healthy population by 2020. It is therefore paramount to find new pharmaceuticals which successfully combat allergic disease.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Kordulewska NK,Kostyra E,Cieślińska A,Matysiewicz M,Fiedorowicz E,Sienkiewicz-Szłapka E

doi

10.1016/j.imbio.2016.11.004

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

571-581

issue

3

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(16)30433-8

journal_volume

222

pub_type

杂志文章

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