Abstract：
:We investigated the effects of ML I and its isolated chains, A and B, in regard to selected functions of phagocytes (human granulocytes, paraffin-oil stimulated M phi from guinea pigs). On these cells, ML I has no cytotoxic effect between 10(-14) and 10(-8) (trypan blue exclusion and ethidium bromide exclusion). Over the same concentration range, ML I and B chain diminish the negative surface charge of M phi and agglutinate M phi at concentrations greater than or equal to 2 X 10(-8) M (ML I) and greater than or equal to 3 X 10(-7) M (B chain), respectively. The diminishing of the negative surface charge shows two peaks, indicating the existence of two types of receptors on the M phi surface with different affinities for sugar-binding sites. Moreover, the B chain shows a third peak at higher concentrations (3 X 10(-8) M) that could be inhibited by D-galactose (greater than or equal to 10(-4) M). In comparison, the A chain reduces the surface charge at concentrations over 3 X 10(-7) M, but D-galactose has no effect on this. By means of the agarose droplet test, the spontaneous migration of M phi is inhibited in the sequence ML I much greater than B chain greater than A chain. The phagocytic activity of human leukocytes tested with a radiometric phagocytosis technique reveals an increasing effect only for the B chain; ML I and the A chain have no effect. Perhaps the mechanism of the described activities of ML I and its B chain are comparable with the action of lymphokines activating M phi.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Metzner G,Franz H,Kindt A,Fahlbusch B,Süss Jdoi
10.1016/S0171-2985(85)80002-4subject
Has Abstractpub_date
1985-07-01 00:00:00pages
461-71issue
5eissn
0171-2985issn
1878-3279pii
S0171-2985(85)80002-4journal_volume
169pub_type
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