Abstract:
:Human urinary colony-stimulating factor (CSF-HU) has been partially purified using five purification procedures (preparation II) for clinical use. In phase I study, six healthy volunteers were injected with preparation II of CSF-HU by a single intravenous droplet infusion. Two volunteers received 4 X 10(6) units (U), two received 8 X 10(6) U, and the final two received 1.2 X 10(7) U of preparation II of CSF-HU. Five volunteers did not have any symptoms, but one volunteer who received 1.2 X 10(7) U complained of transient, mild chilliness during the infusion. Liver function test, coagulation test, urine analysis and patterns of electrocardiogram did not change after infusions. In phase II study on preparation II of CSF-HU, forty-four patients with urological malignancy were infused with a daily dose of 8 X 10(6) U CSF-HU for 7 days from the next day after the end of the second courses of two consecutive courses of the same chemotherapeutic regimen. The average nadirs of leukocytes and granulocytes of 33 evaluable cases were higher in CSF-HU-infused courses (second courses) than in control courses (first courses), with statistic significances. The average period under 2,000 leukocytes/mm3 and the average period under 500 granulocytes/mm3 were shorter in CSF-HU-infused courses than in control courses. These results might indicate that infusions of preparation II partially protect the patients from granulocytopenia after anticancer chemotherapies.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Motoyoshi K,Ishizaka Y,Miura Y,Takaku Fdoi
10.1016/S0171-2985(86)80100-0subject
Has Abstractpub_date
1986-09-01 00:00:00pages
205-12issue
3-5eissn
0171-2985issn
1878-3279pii
S0171-2985(86)80100-0journal_volume
172pub_type
杂志文章相关文献
IMMUNOBIOLOGY文献大全abstract::The inability of spontaneous and some laboratory-induced tumors to stimulate the immune system has continuously raised the question of the validity of using immunological maneuvers in order to control tumor growth. In this project we suggest that a tumor which is nonimmunogenic still has an immunogenic potential that ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(82)80101-0
更新日期:1982-10-01 00:00:00
abstract::Kinetic methods can provide significant information concerning the mechanism of cellular cytotoxicity reactions. Previous kinetic studies of cytotoxic T lymphocytes (Tc) have been hampered by the heterogeneity of the effector cell population tested. We therefore examined the kinetics of lysis mediated by cloned, IL 2 ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(88)80065-2
更新日期:1988-12-01 00:00:00
abstract::The goal of our work was to titer the IgG, IgM and IgA in Pentaglobin® (a preparation enriched in IgM), targeting specific surface antigens of Gram-positive and Gram-negative bacteria as well as a C. albicans strain. Lipopolysaccharides from Gram-negative bacteria, peptidoglycan and lipoteichoic acid from the other mi...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2019.12.006
更新日期:2020-03-01 00:00:00
abstract::Macrophages orchestrate the initiation and resolution of inflammation by producing pro- and anti-inflammatory products. An imbalance in these mediators may originate from a deficient or excessive immune response. Therefore, macrophages are valid therapeutic targets to restore homeostasis under inflammatory conditions....
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.08.010
更新日期:2017-02-01 00:00:00
abstract::We investigated the mRNA expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in human T cell lymphotropic virus type I (HTLV-I) p40tax-transfected U937 cells, a human monoblast cell line. Transfection of HTLV-I p40tax U937 cells induced up-regulation of iNOS mRNA expression and...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(97)80083-6
更新日期:1997-11-01 00:00:00
abstract::Tuberculosis due to Mycobacterium tuberculosis infection is a leading cause of death worldwide. Recognition of this pathogen is crucial for the activation of innate and adaptive immune responses. Nucleotide-binding oligomerization domain (Nod)1 and Nod2 are cytoplasmic receptors that can detect unique muropeptides of ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.07.020
更新日期:2016-01-01 00:00:00
abstract::Considering that imbalance of central tolerance in the thymus contributes to aggressive autoimmunity, we compared the expression of peripheral tissue autoantigens (PTA) genes, which are involved in self-representation in the thymic stroma, of two mouse strains; DBA-1/J (MHC-H2(q)) susceptible and DBA-2/J (MHC-H2(d)) r...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.09.007
更新日期:2011-05-01 00:00:00
abstract::Intraepithelial intestinal T lymphocytes (IEL) bearing alpha beta or gamma delta T cell receptors (TCR) are positioned to serve as a first line of defense against enteric pathogens. To investigate whether intestinal IEL are subject to antigenic selective forces distinct from that influencing (xp T cells in the periphe...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(11)80409-2
更新日期:1994-12-01 00:00:00
abstract::Mugwort pollen allergy is frequent in parts of Europe. As mugwort pollen contains only one major allergen, Art v 1, which harbors only one T cell epitope, we employed mugwort pollen allergy as a model to study allergen-specific T cell responses. However, after 2004, we noticed a drastic decrease in the T cell response...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2019.07.003
更新日期:2019-09-01 00:00:00
abstract::CD40 is essential for optimal B cell activation. It has been shown that CD40 stimulation can augment BCR-induced B cell responses, but the molecular mechanism(s) by which CD40 regulates BCR signaling is poorly understood. In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.09.016
更新日期:2011-05-01 00:00:00
abstract::Cytokines play critical roles in the pathogenesis of Behçet's disease (BD). They mediated many of the effectors and regulatory functions of immune and inflammatory responses. Many studies have linked Interleukin-6 (IL-6) and Interleukin-10 (IL-10) pathologically to BD. Thus, this study aimed to investigate the associa...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.03.004
更新日期:2014-08-01 00:00:00
abstract::Previous work has shown that purified rat macrophages lack both accessory activity for T lymphocyte responses to mitogens and stimulatory activity in a mixed leukocyte reaction, in marked contrast to the potent activity of dendritic cells. This study was designed to re-evaluate macrophages as accessory cells by treati...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(88)80052-4
更新日期:1988-02-01 00:00:00
abstract::A modified immunoperoxidase assay on microscope slides (IPSA) was adopted as a screening procedure for hybridoma supernatants with specificity for human lymphocyte subpopulations. The method proved to be suitable for testing a large number of hybridomas with a minimum of cells and reagents. In addition, the slide-tech...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(83)80010-2
更新日期:1983-03-01 00:00:00
abstract::Pemphigus Vulgaris (PV), a relatively common autoimmune blistering disease in India, primarily mediated by anti-Desmoglein 3 (anti-Dsg3) autoantibodies. T-helper 17 (Th17) and T-regulatory (Treg) cells play significant role in regulating immune homeostasis in autoimmune disorders. To understand immunopathogenesis of P...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.06.008
更新日期:2015-10-01 00:00:00
abstract::A sero-epidemiologic correlation study on immune parameters which would correlate with the frequency of common colds (FCC) had been conducted in 1992. There, an inverse relationship between circulating adhesion molecules CD54 and CD58 and FCC was found. Eighteen months later we performed an analogous assessment in ord...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(96)80005-2
更新日期:1996-01-01 00:00:00
abstract::Ribosomal 30S and 50S subunits as well as total proteins from the large subunit of E. coli ribosomes were found to be potent mitogens for both human adult and cord blood lymphocytes. On the other hand, the RNA fraction of the 50S subunit had only a weak stimulatory capacity suggesting that the protein moiety contains ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(80)80079-9
更新日期:1980-01-01 00:00:00
abstract::Human T-lymphocyte clones showing proliferative and cytotoxic responses specific for HLA antigens were isolated. To obtain enriched numbers of functionally active colonies, the cells were first sensitized in vitro in a tertiary mixed lymphocyte culture (MLC), using 10 stimulating cells for each responding cell. To ass...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(81)80062-9
更新日期:1981-01-01 00:00:00
abstract::Pythiosis is a life-threatening disease caused by the fungus-like microorganism Pythium insidiosum that can lead to death if not treated. Since P. insidiosum has particular cell wall characteristics, pythiosis is difficult to treat, as it does not respond well to traditional antifungal drugs. In our study, we investig...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.10.033
更新日期:2018-03-01 00:00:00
abstract::In this study, the effect of sixteen different enzymes on serum C1 and its subcomponents was investigated. The sixteen enzymes could be divided into three groups. First, enzymes which activate native C1: trypsin (optimal concentration 2.4 x 10(-4) mM); alpha-chymotrypsin (2.3 x 10(3) mM); thrombin (1.0 x 10(-5) mM); p...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(83)80058-8
更新日期:1983-08-01 00:00:00
abstract::Gaucher disease (GD) is associated with upregulation of CD1d and MHC-class II expression by monocytes. While the physiological impact of CD1d upregulation remains uncertain, it has been proposed that MHC-class II upregulation is associated with inflammation. Hereby, we show that the decrease in MHC-class II expression...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.07.002
更新日期:2010-06-01 00:00:00
abstract::The Early Growth Response Genes (EGR-1 to AT133/EGR-4) encode a family of proteins that are composed of three homologous consecutive zinc fingers of the Cys2-His2 type and different flanking sequence. Upon growth stimulation of resting cells the four EGR-genes are simultaneously transcribed. We have analyzed the expre...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(97)80039-3
更新日期:1997-12-01 00:00:00
abstract::Macrophage pre-treatment with bacterial lipopolysaccharide (LPS) boosts subsequent activation of the NLRP3 inflammasome, which controls caspase-1-dependent pro-inflammatory cytokine maturation. Previous work has attributed this phenomenon (known as LPS 'priming') to LPS-dependent induction of NLRP3 expression. Whilst ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2012.07.020
更新日期:2012-12-01 00:00:00
abstract::In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to S...
journal_title:Immunobiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.imbio.2012.05.008
更新日期:2013-03-01 00:00:00
abstract::The century-old tuberculosis vaccine BCG has been the focus of renewed interest due to its well-documented ability to protect against various non-TB pathogens. Much of these broad spectrum protective effects are attributed to trained immunity, the epigenetic and metabolic reprogramming of innate immune cells. As BCG v...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2020.152052
更新日期:2020-12-24 00:00:00
abstract::L-alanine was shown earlier to play a significant role for the proliferation of lymphocytes in vitro. In the present work the effect of L-alanine and some other amino acids on thymocyte proliferation was studied in vivo by local administration into one thymus lobe of guinea pigs. Proliferating cells were pulse labelle...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80487-0
更新日期:1993-06-01 00:00:00
abstract::In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating e...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2009.10.003
更新日期:2010-07-01 00:00:00
abstract::The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism. We could demo...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(11)80540-1
更新日期:1995-07-01 00:00:00
abstract::The major target organ of systemic infection with the intracellular bacterium Listeria monocytogenes is the liver, to where inflammatory leukocytes are rapidly recruited. We determined by reverse transcriptase polymerase chain reaction the early chemokine response in the liver after systemic infection of mice with lis...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(98)80066-1
更新日期:1998-07-01 00:00:00
abstract::Understanding the mechanisms governing the type of induced immune response after microbial invasion, could be of crucial importance for the rational design of a bacteria-based vaccine. Targeting a vaccine directly to dendritic cells (DCs), which are considered the most powerful antigen presenting cells, could be extre...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1078/0171-2985-00094
更新日期:2001-12-01 00:00:00
abstract::The Hepatitis B virus (HBV) e antigen (HBeAg) is a secretory, non-structural protein, and associated with persistent infection of HBV. Previous studies indicate that HBeAg is able to regulate T cell-mediated responses, however, the interaction between HBeAg and the innate immune system is poorly understood. In this st...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.07.008
更新日期:2014-11-01 00:00:00