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Syk mediates BCR- and CD40-signaling integration during B cell activation.

Abstract：

:CD40 is essential for optimal B cell activation. It has been shown that CD40 stimulation can augment BCR-induced B cell responses, but the molecular mechanism(s) by which CD40 regulates BCR signaling is poorly understood. In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated pathways during B cell activation. We found that spleen tyrosine kinase (Syk) is involved in CD40 signaling, and is synergistically activated in B cells in response to BCR/CD40 costimulation. CD40 stimulation alone also activates B cell linker (BLNK), Bruton tyrosine kinase (Btk), and Vav-2 downstream of Syk, and significantly enhances BCR-induced formation of complex consisting of, Vav-2, Btk, BLNK, and phospholipase C-gamma2 (PLC-γ2) leading to activation of extracellular signal-regulated kinase (ERK), p38 mitogen-activated protein kinase, Akt, and NF-κB required for optimal B cell activation. Therefore, our data suggest that CD40 can strengthen BCR-signaling pathway and quantitatively modify BCR signaling during B cell activation.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Ying H,Li Z,Yang L,Zhang J

doi

10.1016/j.imbio.2010.09.016

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

566-70

issue

5

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(10)00186-5

journal_volume

216

pub_type

杂志文章

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