Abstract:
:The suppressive activity of two bovine serum albumin-specific class II-restricted T suppressor cell clones (BVI/5 and 83/2-D11) was compared to that of a feeder cell-independent, IL 2-dependent subline (HF1.IL-2) of an originally antigen-dependent class II-restricted Ts cell clone (HF1). No soluble suppressor factors can be found in BVI/5 and 83/2-D11 Ts cell extracts or culture supernatants under conditions where an unspecific factor can be derived from HF1.IL-2 cells. This factor, when isolated from cell extracts in the presence of n-octyl-beta-D-glycopyranoside, has a molecular weight of 70-80 kD. In absence of this non-ionic detergent, it has a high affinity to membrane fragments and is associated with a molecular weight of 300 kD or more. The data are discussed in connection with recent findings of direct T suppressor to T helper interaction by cell-cell contact.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Bettmann R,Degwert J,Heuer J,Kölsch Edoi
10.1016/S0171-2985(87)80008-6subject
Has Abstractpub_date
1987-05-01 00:00:00pages
339-46issue
3eissn
0171-2985issn
1878-3279pii
S0171-2985(87)80008-6journal_volume
174pub_type
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