Abstract:
:In a rat model, we compared the effects of various soluble products released by T cells, such as the unspecifically acting gamma-interferon or the newly detected alloantigen-induced factors that specifically act on nonlymphoid, hemopoietic bone marrow cells. We found two types of reactivity patterns with regard to the induction of MHC class II antigen expression on these cells. The very same patterns could be demonstrated when we investigated the modulation of their stimulatory capacity, i.e., their immunogenicity in a T proliferation assay. These findings are discussed in relation to the increasing incidence of immunologically mediated graft rejections in clinical bone marrow transplantation following T cell purging.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Wottge HU,Müller-Ruchholtz Wdoi
10.1016/s0171-2985(87)80096-7subject
Has Abstractpub_date
1987-12-01 00:00:00pages
14-23issue
1-2eissn
0171-2985issn
1878-3279pii
S0171-2985(87)80096-7journal_volume
176pub_type
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