Effect of spleen exposure to ultrasound on cellular and antibody-mediated immune reactions in man.

abstract：:Human urinary colony-stimulating factor (CSF-HU) has been partially purified using five purification procedures (preparation II) for clinical use. In phase I study, six healthy volunteers were injected with preparation II of CSF-HU by a single intravenous droplet infusion. Two volunteers received 4 X 10(6) units (U), ...

journal_title：Immunobiology

authors： Motoyoshi K,Ishizaka Y,Miura Y,Takaku F

更新日期：1986-09-01 00:00:00

abstract：:Interleukin (IL)-27, a member of the IL-6/IL-12 heterodimeric cytokine family, induces pro-inflammatory responses including early T helper (Th)1 differentiation and generation of cytotoxic T lymphocytes, and also anti-inflammatory responses including the differentiation to IL-10-producing regulatory T cells, inhibitio...

journal_title：Immunobiology

authors： Shimizu M,Ogura K,Mizoguchi I,Chiba Y,Higuchi K,Ohtsuka H,Mizuguchi J,Yoshimoto T

更新日期：2013-04-01 00:00:00

abstract：:When monocytes are stimulated with LPS (lipopolysaccharide) repeatedly then the initially high expression of the TNF (tumor necrosis factor) gene is only very low, i.e. the cells are tolerant to LPS. Tolerant cells still express the CD14 receptor and they can still be activated to mobilize NF-kappa B into nucleus. Ana...

journal_title：Immunobiology

authors： Frankenberger M,Ziegler-Heitbrock HW

更新日期：1997-12-01 00:00:00

abstract：:Human T-lymphocyte clones showing proliferative and cytotoxic responses specific for HLA antigens were isolated. To obtain enriched numbers of functionally active colonies, the cells were first sensitized in vitro in a tertiary mixed lymphocyte culture (MLC), using 10 stimulating cells for each responding cell. To ass...

journal_title：Immunobiology

authors： Schendel DJ,Wank R

更新日期：1981-01-01 00:00:00

abstract：:Surfactant protein D has multiple functions in innate immunity in the lung. The generation of SP-D knock-out mice has revealed a central role for this protein in the control of lung inflammation. Accumulating evidence in mouse models of infection and inflammation indicates that truncated recombinant forms of surfactan...

journal_title：Immunobiology

authors： Clark H,Reid KB

更新日期：2002-09-01 00:00:00

abstract：:This study investigated the actin scavenger function of the vitamin D binding protein (DBP) in vivo using DBP null (-/-) mice. Intravenous injection of G-actin into wild-type (DBP+/+) and DBP-/- mice showed that contrary to expectations, DBP+/+ mice developed more severe acute lung inflammation. Inflammation was restr...

journal_title：Immunobiology

authors： Ge L,Trujillo G,Miller EJ,Kew RR

更新日期：2014-03-01 00:00:00

abstract：:Mast cells serve important roles as sentinels against bacterial infection by secreting mediators stored in granules. Much of their effectiveness depends upon recruiting and/or modulating other immune cells. The location of mast cells implies that they recognize pathogens invading tissues or mucosal tissues. Acinetobac...

journal_title：Immunobiology

authors： Kikuchi-Ueda T,Kamoshida G,Ubagai T,Nakano R,Nakano A,Akuta T,Hikosaka K,Tansho-Nagakawa S,Kikuchi H,Ono Y

更新日期：2017-11-01 00:00:00

abstract：:α-Synuclein plays a crucial role in Parkinson's disease and dementias defined as synucleinopathies. α-Synuclein is expressed in hematopoietic and immune cells, but its functions in hematopoiesis and immune responses are unknown. We utilized α-synuclein(-/-) (KO) mice to investigate its role in hematopoiesis and B cell...

journal_title：Immunobiology

authors： Xiao W,Shameli A,Harding CV,Meyerson HJ,Maitta RW

更新日期：2014-11-01 00:00:00

abstract：:Previous work has shown that purified rat macrophages lack both accessory activity for T lymphocyte responses to mitogens and stimulatory activity in a mixed leukocyte reaction, in marked contrast to the potent activity of dendritic cells. This study was designed to re-evaluate macrophages as accessory cells by treati...

journal_title：Immunobiology

authors： Bowers WE,Ruhoff MS,Goodell EM,Stoltenborg JK

更新日期：1988-02-01 00:00:00

abstract：:Peptide immunotherapy (PIT) represents a safe and efficacious therapeutic modality for allergic diseases. Present study evaluates immunotherapeutic potential of T cell peptides of major cockroach allergen, Per a 10 in murine model of airway allergy. Treatment with peptides T-P8 and T-P10 demonstrated maximal resolutio...

journal_title：Immunobiology

authors： Govindaraj D,Sharma S,Singh N,Arora N

更新日期：2019-05-01 00:00:00

abstract：:Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activat...

journal_title：Immunobiology

authors： Nymo S,Niyonzima N,Espevik T,Mollnes TE

更新日期：2014-10-01 00:00:00

abstract：:In contrast to murine spleen M phi, resident peritoneal M phi from health mice express very little Forssman glycolipid antigen (Fo). The following experiments suggest that Fo expression by peritoneal M phi may be associated with inflammation. Balb/c and CBA/J mice were given inflammatory stimuli by i.p. injection of l...

journal_title：Immunobiology

authors： von Kleist R,Schmitt E,Westermann J,Mühlradt PF

更新日期：1990-06-01 00:00:00

abstract：:We investigated the mRNA expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in human T cell lymphotropic virus type I (HTLV-I) p40tax-transfected U937 cells, a human monoblast cell line. Transfection of HTLV-I p40tax U937 cells induced up-regulation of iNOS mRNA expression and...

journal_title：Immunobiology

authors： Goto H,Nakamura T,Shirabe S,Ueki Y,Nishiura Y,Furuya T,Tsujino A,Nakane S,Eguchi K,Nagataki S

更新日期：1997-11-01 00:00:00

abstract：:A modified immunoperoxidase assay on microscope slides (IPSA) was adopted as a screening procedure for hybridoma supernatants with specificity for human lymphocyte subpopulations. The method proved to be suitable for testing a large number of hybridomas with a minimum of cells and reagents. In addition, the slide-tech...

journal_title：Immunobiology

authors： Morich FJ,Momburg F,Moldenhauer G,Hartmann KU,Bross KJ

更新日期：1983-03-01 00:00:00

abstract：:Respiratory viral infections have been implicated in the origin of, protection from and exacerbation of allergy-related symptoms in a variety of ways. Viral infections are closely linked to infantile wheezing. Severe bronchiolitis in early infancy may predispose to chronic childhood asthma as well as allergic sensitiz...

journal_title：Immunobiology

authors： Xepapadaki P,Papadopoulos NG

更新日期：2007-01-01 00:00:00

abstract：:Neutrophilic granulocytes (PMN) are attracted to sites of inflammation by chemotactic factors, the most potent of which are the complement split product C5a, the leukotriene B4 and the bacterial chemotactic factor-related tripeptide formyl-methionyl-leucyl-phenylalanine (FMLP). In addition to inducing directed migrati...

journal_title：Immunobiology

authors： Kownatzki E,Uhrich S,Grüninger G

更新日期：1988-09-01 00:00:00

abstract：:CD8-positive cytotoxic T cells (CTL) recognize antigenic peptides in combination with major histocompatibility complex (MHC) class I molecules on the surface of syngeneic antigen presenting cells (APC). In the present paper we show that cells from tumor antigen-specific CTL clones present their cognate antigenic pepti...

journal_title：Immunobiology

authors： Staege MS,Schneider J,Eulitz M,Scholz S,Bornkamm GW,Wölfel T,Reske-Kunz AB

更新日期：2000-01-01 00:00:00

abstract：:Immunosuppressive effects of corticosteroids are generally known, but the mechanisms influencing the immune system are poorly understood. However, a correlation between cortisol levels and cytokine production has been reported by several investigators. In the present study we determined cortisol concentrations in huma...

journal_title：Immunobiology

authors： Reissland P,Wandinger KP

更新日期：1999-06-01 00:00:00

abstract：:The alarming rise of obesity and type 2 diabetes (T2D) has put a tremendous strain on global healthcare systems. Over the past decade extensive research has focused on the role of macrophages as key mediators of inflammation in T2D. The inflammatory environment in the obese adipose tissue and pancreatic β-cell islets ...

journal_title：Immunobiology

authors： Ahmed M,de Winther MPJ,Van den Bossche J

更新日期：2017-10-01 00:00:00

abstract：:When sheep red blood cells (SRBC) were injected intraperitoneally (i.p.), intravenously (i.v.), or into the Peyer's patches, definite plaque-forming cell (PFC) and rosette-forming cell (RFC) responses were induced in the spleen but not in the mesenteric lymph nodes (MLN). When SRBC were injected directly into the sple...

journal_title：Immunobiology

authors： Kojima T,Kamei H,Kondo T,Nakashima I,Kato N

更新日期：1982-05-01 00:00:00

abstract：:Culture supernatants (CS) from Hodgkin derived cell lines have previously been shown to contain colony stimulating activity (CSF) for human cord blood cells, fetal bone marrow and fetal liver cells. In this study 3-day CS from four Hodgkin lines (L428, L538, L540, L591) and two sublines (L428KS, L428KSA) were examined...

journal_title：Immunobiology

authors： Kortmann C,Burrichter H,Monner D,Jahn G,Diehl V,Peter HH

更新日期：1984-05-01 00:00:00

abstract：:Dogs infected with Leishmania infantum have a reduced number of T lymphocytes. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family that is expressed by immune cells, and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces the deactivation or apoptosis of T cells. This study aimed to evaluate the expres...

journal_title：Immunobiology

authors： Chiku VM,Silva KL,de Almeida BF,Venturin GL,Leal AA,de Martini CC,de Rezende Eugênio F,Dos Santos PS,de Lima VM

更新日期：2016-08-01 00:00:00

abstract：:Several, and not necessarily alternative, pathogenic mechanisms have been suggested to sustain the thrombophilic diathesis of the anti-phospholipid syndrome. Among them, interference of anti-phospholipid antibodies with cell acting in the coagulation cascade likely plays a major role. Anti-phospholipid antibodies have...

journal_title：Immunobiology

authors： Riboldi P,Gerosa M,Raschi E,Testoni C,Meroni PL

更新日期：2003-01-01 00:00:00

abstract：:The ability of RPMI 1640 enriched with FCS or AATSZ (L-alanine, BSA, human transferrin, zinc chloride, and sodium selenite) to support mitogen-induced activation (G0-G1 shift) and proliferation (G1-S shift) of thymocytes has been investigated. The two culture media were found to be equally supportive. In terms of viab...

journal_title：Immunobiology

authors： Kristensen F,Walker C,Müller J,de Weck AL

更新日期：1982-05-01 00:00:00

abstract：:The majority of B lymphocytes, virgin T lymphocytes and a subpopulation of memory T cells express the addressin, L-selectin. Natural killer (NK) cells in rodents and humans also express L-selectin. We have shown that a similar proportion (40%) of NK cells in mouse spleen also express the integrin, CD18Mac-1, and moreo...

journal_title：Immunobiology

authors： Lejtenyi D,Osmond DG,Miller SC

更新日期：2003-01-01 00:00:00

abstract：:Exposure of resident peritoneal macrophages or thioglycollate-induced macrophages (TG-Mø) to influenza or Sendai virus-infected spleen cell culture supernatants (MAS) resulted in macrophage activation. When normal resident macrophages were used as effector cells, both infected P815 and L929 cells were lysed in the pre...

journal_title：Immunobiology

authors： Mak NK,Ada GL

更新日期：1984-05-01 00:00:00

abstract：:Macrophages are key players not only during initiation of inflammation but also during its resolution. This is achieved by their high functional plasticity and the demand to recognize an enormous repertoire of danger signals and cytokines/chemokines derived from adaptive immune cells. Studies predominantly conducted o...

journal_title：Immunobiology

authors： Ley S,Weigert A,Brüne B

更新日期：2010-09-01 00:00:00

abstract：:A case of a 35-year-old female with multiple sclerosis is reported who developed without apparent prior sensitization a lymphocytotoxic antibody with anti-HLA-B8 specificity. The antibody persisted for several years with the same titer. The cytotoxic activity of the patient's serum was contained within the IgM fractio...

journal_title：Immunobiology

authors： Lenhard V,Diehm H,Römer W,Rauterberg EW,Kownatzki E,Roelcke D

更新日期：1982-02-01 00:00:00

abstract：UNLABELLED:The lymphoid tissue of the appendix is considered as part of the gut-associated lymphoid tissue (GALT). In order to understand better the immunological significance of the appendix we analyzed the cellular composition of normal and inflamed human appendix tissue by flow cytometer with special attention to ex...

journal_title：Immunobiology

authors： Somekh E,Serour F,Gorenstein A,Vohl M,Lehman D

更新日期：2000-01-01 00:00:00

abstract：:During bacterial peritonitis of patients on continuous ambulatory peritoneal dialysis (CAPD) leukocytes, particularly polymorphonuclear neutrophilic granulocytes (PMNs), migrate into the peritoneal cavity. However, at the site of inflammation PMNs are not sufficiently able to protect the host against micro-organisms. ...

journal_title：Immunobiology

authors： Elsner J,Sach M,Knopf HP,Norgauer J,Kapp A,Schollmeyer P,Dobos GJ

更新日期：1995-08-01 00:00:00