Increased cortisol levels in human umbilical cord blood inhibit interferon alpha production of neonates.

abstract：BACKGROUND:Ficolins serve as soluble recognition molecules in the lectin pathway of complement. They are known to participate in the systemic host-response to infection but their role in local pulmonary defence is still incompletely understood. The purpose of this study was to clarify whether acute lung and systemic in...

journal_title：Immunobiology

authors： Plovsing RR,Berg RM,Munthe-Fog L,Konge L,Iversen M,Møller K,Garred P

更新日期：2016-05-01 00:00:00

abstract：:By quantitative and functional methods, changes were assessed in NK(ASGM-1+) cell numbers and NK cell-mediated lytic function of the spleen and bone marrow of mice bearing a tumor of hemopoietic origin (FLV-induced erythroleukemia) for 9 days +/- simultaneous administration of indomethacin (10 micrograms/ml drinking w...

journal_title：Immunobiology

authors： Christopher FL,Dussault I,Miller SC

更新日期：1991-12-01 00:00:00

abstract：:In mice, monoclonal antibody (mAb) to the alpha1 integrin abrogate gastro-intestinal damage during graft-versus-host-disease (GVHD), suggesting anti alpha1 mAb as candidates for treatment in humans as well. Our current data show that one such reagent, mAb 1B3.1, when immobilized to plastic wells via rabbit- anti murin...

journal_title：Immunobiology

authors： Bank I,Hardan I,Lokshin E,Nas D,Miron S,Ohad D,Spong S,Garrod DR

更新日期：2000-09-01 00:00:00

abstract：:Surfactant protein D has multiple functions in innate immunity in the lung. The generation of SP-D knock-out mice has revealed a central role for this protein in the control of lung inflammation. Accumulating evidence in mouse models of infection and inflammation indicates that truncated recombinant forms of surfactan...

journal_title：Immunobiology

authors： Clark H,Reid KB

更新日期：2002-09-01 00:00:00

abstract：:Based on our findings that HIV-1 gp41 independently of CD4 can bind to the human helper T lymphoid cell line H9, B cell line Raji and monocyte cell line U937, we characterized putative binding of HIV-1 gp41 to human peripheral blood lymphocytes (PBLs) and monocytes. Using flow cytometry (FACS), we demonstrated that th...

journal_title：Immunobiology

authors： Chen YH,Böck G,Vornhagen R,Steindl F,Katinger H,Dierich MP

更新日期：1993-08-01 00:00:00

abstract：:Five mouse hybridoma cell lines producing monoclonal antibody against bovine luteinizing hormone (LH) have been established and the respective antibodies characterized by radioimmunoassay, immunofluorescence and immunoelectrophoresis. All antibodies belong to the IgG class and bind to staphylococcus protein A. Intrasp...

journal_title：Immunobiology

authors： Kofler R,Kalchschmid E,Berger P,Wick G

更新日期：1981-01-01 00:00:00

abstract：:Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium frequently isolated from lesions of patients with localized aggressive periodontitis. Lipopolysaccharide (LPS), a major cell wall component of Gram-negative bacteria, stimulates innate immune cells via Toll-like receptor 4 (TLR4) to initiate inflammato...

journal_title：Immunobiology

authors： Park OJ,Cho MK,Yun CH,Han SH

更新日期：2015-09-01 00:00:00

abstract：:Most malignant tumors contain so-called tumor-associated macrophages (TAM) as a major component of their leukocytic infiltrate. To investigate the impact of the tumor microenvironment on activation and differentiation of macrophages, we established a 3-dimensional model system by culturing human monocytes within multi...

journal_title：Immunobiology

authors： Gottfried E,Faust S,Fritsche J,Kunz-Schughart LA,Andreesen R,Miyake K,Kreutz M

更新日期：2003-01-01 00:00:00

abstract：:Activity of acid phosphatase was found to be higher in T than in non-T cells of human peripheral blood lymphocytes. The T cell mitogen PHA induced an increase in the magnitude of acid phosphatase activity, while the B cell mitogen LPS was not able to produce any effect on acid phosphatase activity. Acid phosphatase ac...

journal_title：Immunobiology

authors： Myśliwska J,Myśliwski A,Grzegorzewski K,Witkowski J

更新日期：1985-03-01 00:00:00

abstract：:A review of 250 patients with the catastrophic antiphospholipid (Asherson's) syndrome (CAPS) taken from the web site organized by the Europhospholipid Group (http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) is presented in this paper. A short historical overview of the antiphospholipid syndrome (APS) is followed by a descr...

journal_title：Immunobiology

authors： Asherson RA

更新日期：2005-01-01 00:00:00

abstract：:It is established that (1) subclinical Bordetella pertussis colonization of the nasopharynx persists in highly vaccinated populations, and (2) B. pertussis toxin is a potent adjuvant that, when co-administered with neural antigens, induces neuropathology in experimental autoimmune encephalomyelitis, the principle anim...

journal_title：Immunobiology

authors： Rubin K,Glazer S

更新日期：2016-04-01 00:00:00

abstract：:Kinetic methods can provide significant information concerning the mechanism of cellular cytotoxicity reactions. Previous kinetic studies of cytotoxic T lymphocytes (Tc) have been hampered by the heterogeneity of the effector cell population tested. We therefore examined the kinetics of lysis mediated by cloned, IL 2 ...

journal_title：Immunobiology

authors： Callewaert DM,Meyers P,Hiernaux J,Radcliff G

更新日期：1988-12-01 00:00:00

abstract：:Attenuating the sepsis-induced systemic inflammatory response, with subsequent homeostatic imbalance, has for years been one of the main tasks in sepsis related research. Complement and the TLR family constitute two important upstream sensor and effector-systems of innate immunity. Although they act as partly independ...

journal_title：Immunobiology

authors： Barratt-Due A,Pischke SE,Brekke OL,Thorgersen EB,Nielsen EW,Espevik T,Huber-Lang M,Mollnes TE

更新日期：2012-11-01 00:00:00

abstract：:The macrophage population of the gastro-intestinal tract of the rat was studied by using a set of three monoclonal antibodies (ED1, ED2 and ED3) directed against rat macrophages, an anti-Ia monoclonal antibody and by performing an acid phosphatase reaction. The lamina propria of the whole gastro-intestinal tract compr...

journal_title：Immunobiology

authors： Sminia T,Jeurissen SH

更新日期：1986-08-01 00:00:00

abstract：:Interleukin-6 (IL-6) induced increased, leukocyte and platelet counts on around day 20 when it was administered into [BALB/c-->C3H/He] bone marrow chimeras from day 1 to day 12. Increased leukocyte counts and hemoglobin (Hb) levels were also observed at around day 60 and from day 41 to 80, respectively. On the other h...

journal_title：Immunobiology

authors： Imamura M,Hashino S,Kobayashi H,Tanaka J,Imai K,Han M,Fujii Y,Kobayashi M,Higa T,Kasai M

更新日期：1994-06-01 00:00:00

abstract：:The mechanisms of tolerance induction occurring in the course of allergen-specific immunotherapy have not been elucidated in full detail. Our study aimed to characterize high zone tolerance in mouse models of type I allergy and of allergic airway inflammation induced by subcutaneous sensitization of mice with high dos...

journal_title：Immunobiology

authors： Raker V,Stein J,Montermann E,Maxeiner J,Taube C,Reske-Kunz AB,Sudowe S

更新日期：2015-04-01 00:00:00

abstract：:α-Synuclein plays a crucial role in Parkinson's disease and dementias defined as synucleinopathies. α-Synuclein is expressed in hematopoietic and immune cells, but its functions in hematopoiesis and immune responses are unknown. We utilized α-synuclein(-/-) (KO) mice to investigate its role in hematopoiesis and B cell...

journal_title：Immunobiology

authors： Xiao W,Shameli A,Harding CV,Meyerson HJ,Maitta RW

更新日期：2014-11-01 00:00:00

abstract：:Surfactant proteins SP-A and SP-D are pattern recognition innate immune molecules that belong to the C-type lectin family. In lungs, they play an important role in the clearance of pathogens and control of inflammation. SP-A and SP-D are also expressed in the female reproductive tract where they play an important role...

journal_title：Immunobiology

authors： Madhukaran SP,Koippallil Gopalakrishnan AR,Pandit H,Marri ED,Kouser L,Jamil K,Alhamlan FS,Kishore U,Madan T

更新日期：2016-02-01 00:00:00

abstract：:The inability of spontaneous and some laboratory-induced tumors to stimulate the immune system has continuously raised the question of the validity of using immunological maneuvers in order to control tumor growth. In this project we suggest that a tumor which is nonimmunogenic still has an immunogenic potential that ...

journal_title：Immunobiology

authors： Klein BY,Sharon R,Tarcic N,Naor D

更新日期：1982-10-01 00:00:00

abstract：:Purified CD8+ T cells from influenza A/WSN-immune BALB/c (H-2d) mice respond with the generation of secondary A/WSN-specific Tc cells in vitro when stimulated with a synthetic peptide (NPP) with a sequence derived from influenza A virus nucleoprotein with high affinity for Kd class I MHC molecules. The process of the ...

journal_title：Immunobiology

authors： Kos FJ,Müllbacher A

更新日期：1992-11-01 00:00:00

abstract：:The majority of B lymphocytes, virgin T lymphocytes and a subpopulation of memory T cells express the addressin, L-selectin. Natural killer (NK) cells in rodents and humans also express L-selectin. We have shown that a similar proportion (40%) of NK cells in mouse spleen also express the integrin, CD18Mac-1, and moreo...

journal_title：Immunobiology

authors： Lejtenyi D,Osmond DG,Miller SC

更新日期：2003-01-01 00:00:00

abstract：:During bacterial peritonitis of patients on continuous ambulatory peritoneal dialysis (CAPD) leukocytes, particularly polymorphonuclear neutrophilic granulocytes (PMNs), migrate into the peritoneal cavity. However, at the site of inflammation PMNs are not sufficiently able to protect the host against micro-organisms. ...

journal_title：Immunobiology

authors： Elsner J,Sach M,Knopf HP,Norgauer J,Kapp A,Schollmeyer P,Dobos GJ

更新日期：1995-08-01 00:00:00

abstract：:Macrophage pre-treatment with bacterial lipopolysaccharide (LPS) boosts subsequent activation of the NLRP3 inflammasome, which controls caspase-1-dependent pro-inflammatory cytokine maturation. Previous work has attributed this phenomenon (known as LPS 'priming') to LPS-dependent induction of NLRP3 expression. Whilst ...

journal_title：Immunobiology

authors： Schroder K,Sagulenko V,Zamoshnikova A,Richards AA,Cridland JA,Irvine KM,Stacey KJ,Sweet MJ

更新日期：2012-12-01 00:00:00

abstract：:C1q binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. C1q binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology o...

journal_title：Immunobiology

authors： Sim RB,Kishore U,Villiers CL,Marche PN,Mitchell DA

更新日期：2007-01-01 00:00:00

abstract：:Acute lung injury (ALI) is an acute inflammatory disorder. Toll-like receptor-4 (TLR-4) and Stanniocalcin -1 (STC-1) had roles in lung endothelial protection. This study aims to assess TLR-4 and SCT-1 genes expressions in peripheral blood of ALI patients. Total RNA was extracted from peripheral blood of 48 subjects (2...

journal_title：Immunobiology

authors： Esawy MM,Shabana MA,Baioumy SA,Ismail NA

更新日期：2019-11-01 00:00:00

abstract：:Macrophages are major effector cells of the innate immune system, and appropriate regulation of macrophage function requires the integration of multiple signalling inputs derived from the recognition of host factors (e.g. interferon-gamma/IFNgamma) and pathogen products (e.g. toll-like receptor/TLR agonists). The prof...

journal_title：Immunobiology

authors： Schroder K,Sweet MJ,Hume DA

更新日期：2006-01-01 00:00:00

abstract：:CD4(+)CD25(+)Foxp3(+) T regulatory cells (Tregs) and CD1d-restricted invariant natural killer T (iNKT) cells are two cell types that are known to regulate immune reactions. Depletion or inactivation of Tregs using specific anti-CD25 antibodies in combination with immunostimulation is an attractive modality especially ...

journal_title：Immunobiology

authors： Rosalia RA,Štěpánek I,Polláková V,Šímová J,Bieblová J,Indrová M,Moravcová S,Přibylová H,Bontkes HJ,Bubeník J,Sparwasser T,Reiniš M

更新日期：2013-06-01 00:00:00

abstract：:Intestinal epithelial cells produce cytokines in response to bacterial peptidoglycan (PGN), which is detected by several classes of pattern-recognition receptors (PRRs) as peptidoglycan recognition proteins (PGlyRPs), Toll-like receptor 2 (TLR2) and NOD receptors. All types of PGlyRPs recognize bacterial peptidoglycan...

journal_title：Immunobiology

authors： Zenhom M,Hyder A,de Vrese M,Heller KJ,Roeder T,Schrezenmeir J

更新日期：2012-04-01 00:00:00

abstract：:We hypothesized that anti-citrullinated protein antibodies (ACPAs) could affect the expression of miRNAs in monocytes and contribute to the inflammatory responses in rheumatoid arthritis (RA). The expression profiles of 270 human miRNAs, co-cultured with ACPAs or human immunoglobulin G (IgG), were analyzed using real-...

journal_title：Immunobiology

authors： Lai NS,Yu HC,Yu CL,Koo M,Huang HB,Lu MC

更新日期：2015-12-01 00:00:00

abstract：:A "lectin-like" receptor for bacterial cell wall sugars, originally described in the membrane of mouse peritoneal macrophages, which facilitates binding of various bacteria to the macrophage surface, has now been shown to be present on most phagocytes from a variety of species. The role of such a receptor in the infla...

journal_title：Immunobiology

authors： Weir DM,Stewart J,Glass E

更新日期：1982-04-01 00:00:00