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Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction.

Abstract：

:Macrophage pre-treatment with bacterial lipopolysaccharide (LPS) boosts subsequent activation of the NLRP3 inflammasome, which controls caspase-1-dependent pro-inflammatory cytokine maturation. Previous work has attributed this phenomenon (known as LPS 'priming') to LPS-dependent induction of NLRP3 expression. Whilst this plays a role, here we demonstrate that rapid LPS priming of NLRP3 inflammasome activation can occur independently of NLRP3 induction, since the priming effect of LPS is still apparent at short pre-treatment times in which NLRP3 protein expression remains unchanged. Furthermore, rapid LPS priming is still evident in Nlrp3(-/-) primary macrophages with NLRP3 expression reconstituted using a constitutive promoter. Similarly, we found that LPS potentiates AIM2 inflammasome activation to submaximal doses of cytosolic DNA without concomitant upregulation of AIM2 protein expression. Our data suggest that, in addition to augmenting NLRP3 inflammasome activity via NLRP3 induction, LPS boosts caspase-1 activation by the NLRP3 and AIM2 inflammasomes by an acute mechanism that is independent of inflammasome sensor induction.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Schroder K,Sagulenko V,Zamoshnikova A,Richards AA,Cridland JA,Irvine KM,Stacey KJ,Sweet MJ

doi

10.1016/j.imbio.2012.07.020

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1325-9

issue

12

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(12)00184-2

journal_volume

217

pub_type

杂志文章

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