Abstract：
:A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3dg prepared from human or mouse serum and to u.v.-inactivated Epstein-Barr virus. SDS-PAGE analysis of culture supernates of B-lymphoid cells labelled by growth in medium containing 35S-methionine revealed a major component of molecular weight approximately 130 kDa and another band at 30 kDa. Incubation with endoglycosidase F reduced the size of the high molecular weight component. Gel filtration of untreated serum or culture supernate revealed that, in its native state, sCR2 behaved as a molecule or complex of apparent molecular weight 320 kDa. Possible explanations are discussed.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Ling NR,Brown Bdoi
10.1016/S0171-2985(11)80656-Xsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
403-14issue
2-4eissn
0171-2985issn
1878-3279pii
S0171-2985(11)80656-Xjournal_volume
185pub_type
杂志文章相关文献
IMMUNOBIOLOGY文献大全abstract：:This study assessed variation in plasma levels of the complement regulatorC1 inhibitor (C1inh) in patients with age related macular degeneration (AMD) and controls. Plasma from391 AMD cases and 370 controls was assayed by rate nephelometry to determine C1inh protein levels. Protein levels were analysed for relationshi...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2011.07.015
更新日期：2012-02-01 00:00:00
abstract：:Macrophage functions in the immune response depend on their ability to infiltrate tissues and organs. The penetration between and within the tissues requires degradation of extracellular matrix (ECM), a function performed by the specialized, endopeptidase- and actin filament- rich organelles located at the ventral sur...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2018.07.009
更新日期：2018-11-01 00:00:00
abstract：:Gaucher disease (GD) is associated with upregulation of CD1d and MHC-class II expression by monocytes. While the physiological impact of CD1d upregulation remains uncertain, it has been proposed that MHC-class II upregulation is associated with inflammation. Hereby, we show that the decrease in MHC-class II expression...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2009.07.002
更新日期：2010-06-01 00:00:00
abstract：:Interleukin-1beta (IL-1beta) is a potent proinflammatory cytokine that initiates and amplifies a wide variety of effects associated with innate immunity and host responses to microbial invasion and tissue injury. Production and release of IL-1beta are stimulated by either pathogen-associated molecular pattern molecule...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2008.11.007
更新日期：2009-01-01 00:00:00
abstract：:Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium frequently isolated from lesions of patients with localized aggressive periodontitis. Lipopolysaccharide (LPS), a major cell wall component of Gram-negative bacteria, stimulates innate immune cells via Toll-like receptor 4 (TLR4) to initiate inflammato...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2015.05.008
更新日期：2015-09-01 00:00:00
abstract：:Tumor necrosis factor (TNF) has been determined as an endogenous mediator for endotoxin-induced tumor necrosis. This macrophage product has been biochemically characterized and its protein structure defined by molecular cloning of the TNF gene. Experiments with antibodies to TNF demonstrated that TNF acts as an effect...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(86)80110-3
更新日期：1986-09-01 00:00:00
abstract：INTRODUCTION:The interaction between the immune system and malignant diseases is a proven key target for cancer therapy. We describe an innovative 3D cell culture system comprising both immune and cancer cells to evaluate their interaction and immune cell infiltration to provide an innovative in vitro screening of immu...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2015.12.010
更新日期：2016-05-01 00:00:00
abstract：:CD40 is essential for optimal B cell activation. It has been shown that CD40 stimulation can augment BCR-induced B cell responses, but the molecular mechanism(s) by which CD40 regulates BCR signaling is poorly understood. In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2010.09.016
更新日期：2011-05-01 00:00:00
abstract：:A "lectin-like" receptor for bacterial cell wall sugars, originally described in the membrane of mouse peritoneal macrophages, which facilitates binding of various bacteria to the macrophage surface, has now been shown to be present on most phagocytes from a variety of species. The role of such a receptor in the infla...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(82)80090-9
更新日期：1982-04-01 00:00:00
abstract：:Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxi...
journal_title：Immunobiology
pub_type： 杂志文章
doi：
更新日期：1979-09-01 00:00:00
abstract：:The suppressive activity of two bovine serum albumin-specific class II-restricted T suppressor cell clones (BVI/5 and 83/2-D11) was compared to that of a feeder cell-independent, IL 2-dependent subline (HF1.IL-2) of an originally antigen-dependent class II-restricted Ts cell clone (HF1). No soluble suppressor factors ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(87)80008-6
更新日期：1987-05-01 00:00:00
abstract：:Mast cells serve important roles as sentinels against bacterial infection by secreting mediators stored in granules. Much of their effectiveness depends upon recruiting and/or modulating other immune cells. The location of mast cells implies that they recognize pathogens invading tissues or mucosal tissues. Acinetobac...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2017.05.015
更新日期：2017-11-01 00:00:00
abstract：:Several, and not necessarily alternative, pathogenic mechanisms have been suggested to sustain the thrombophilic diathesis of the anti-phospholipid syndrome. Among them, interference of anti-phospholipid antibodies with cell acting in the coagulation cascade likely plays a major role. Anti-phospholipid antibodies have...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1078/0171-2985-00211
更新日期：2003-01-01 00:00:00
abstract：:To recognize patients with inhibitory and neutralizing auto-antibodies to interferon-γ (AutoAbs-IFN-γ) presenting with the sporadic phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) mainly characterized by recurrent intracellular mycobacterium or/and salmonella infections, we comprehensively invest...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2012.08.281
更新日期：2013-05-01 00:00:00
abstract：:Macrophages orchestrate the initiation and resolution of inflammation by producing pro- and anti-inflammatory products. An imbalance in these mediators may originate from a deficient or excessive immune response. Therefore, macrophages are valid therapeutic targets to restore homeostasis under inflammatory conditions....
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2016.08.010
更新日期：2017-02-01 00:00:00
abstract：:Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2016.11.013
更新日期：2017-06-01 00:00:00
abstract：:The expression level of Mac-1 on the surface of neutrophils is an important indicator of neutrophil activation. Under pathological conditions, Mac-1 is believed a key adhesion molecule that facilitates cancer progression and mediates the adhesion of tumour cells to the endothelium of blood vessels. Our previous findin...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2015.10.003
更新日期：2016-02-01 00:00:00
abstract：:In mice, monoclonal antibody (mAb) to the alpha1 integrin abrogate gastro-intestinal damage during graft-versus-host-disease (GVHD), suggesting anti alpha1 mAb as candidates for treatment in humans as well. Our current data show that one such reagent, mAb 1B3.1, when immobilized to plastic wells via rabbit- anti murin...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/s0171-2985(00)80031-5
更新日期：2000-09-01 00:00:00
abstract：:This study tested the hypothesis that prolonged severe hypoxia during monocyte to macrophage differentiation results in macrophages with a pattern of gene expression and phenotype distinct from those maturing in normal oxygen levels. Macrophages accumulate in hypoxic and anoxic areas within pathological sites such as ...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2010.12.005
更新日期：2011-07-01 00:00:00
abstract：:Monoclonal mouse anti-Thy-1.2 antibody of IgG3 isotype (MTA) inhibits in a significant and long-term manner the regional graft-versus-host reaction (GVHR) when administered to donors as well as to recipients. The process of sensitization in the reaction of delayed type hypersensitivity to SRBC (DTH) is, on the other h...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(88)80049-4
更新日期：1988-07-01 00:00:00
abstract：:Recent studies have suggested that odontoblasts are involved in the dental pulp immune response to oral pathogens that invade human dentin during the caries process. How odontoblasts regulate the early inflammatory and immune pulp response to Gram-positive bacteria, which predominate in shallow and moderate dentin car...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2010.08.006
更新日期：2011-04-01 00:00:00
abstract：:Natural killer (NK) cells are the main population of leukocytes in decidua during the first trimester of pregnancy. NK cells can have contact with trophoblast cells during pregnancy, which raises the possibility of mutual influence. This research aimed to evaluate the proliferation and phenotype of peripheral blood NK...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2020.151910
更新日期：2020-05-01 00:00:00
abstract：:The aim of this study was to evaluate some immunological patterns involved in natural and acquired resistance against MHV3 using the original model of genetically modified lines of mice selected for high (HIII) and low (LIII) antibody responsiveness. As previously shown, a lower pre-existing anti-MHV antibody level wa...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1078/0171-2985-00239
更新日期：2003-01-01 00:00:00
abstract：:According to present concepts, innate immunity plays an important role in tumor surveillance and immune modulation. The state of NK cells depends on the balance between inhibitory and activating signals from corresponding receptors. As one of the activating receptors, NKG2D recognises some self ligands such as MICA/B ...
journal_title：Immunobiology
pub_type： 杂志文章,评审
doi：10.1016/j.imbio.2004.04.008
更新日期：2004-01-01 00:00:00
abstract：:Porphyromonas gingivalis 381 lipid A induced strong mitogenic response in splenic B cells separated from LPS-non-responsive C3H/HeJ mice as well as LPS-responsive C3H/HeN mice, by using a magnetic cell sorting system. The lipid A also exhibited mitogenic activity in splenic T cells. P. gingivalis lipid A induced lower...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(96)80062-3
更新日期：1996-01-01 00:00:00
abstract：:Chitin and β-glucan are conserved throughout evolution in the fungal cell wall and are the most common polysaccharides in fungal species. Together, these two polysaccharides form a structural scaffold that is essential for the survival of the fungus. In the present study, we demonstrated that Aspergillus fumigatus alk...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2013.10.003
更新日期：2014-03-01 00:00:00
abstract：:Reggie-1/flotillin-2 is a plasma membrane-associated cytoplasmic protein, which defines non-caveolar raft microdomains. Reggie-1/flotillin-2 is enriched in detergent insoluble (TX100) membrane fractions (DIG), co-localizes with activated GPI-linked proteins and the fyn-kinase in neurons and T cells, and thus apparentl...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1078/0171-2985-00114
更新日期：2002-03-01 00:00:00
abstract：:Trypanosoma cruzi is a real challenge to the host's immune system, because it requires strong humoral and cellular immune response to remove circulating trypomastigote forms, and to prevent the replication of amastigote forms in tissues, involving many regulator and effector components. This protozoan is responsible f...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/j.imbio.2014.10.003
更新日期：2015-03-01 00:00:00
abstract：:Peritoneal as well as peripheral blood, but not spleen macrophages inhibit natural killer (NK) cell activity directed against adherent growing target cells. Inhibition was observed with macrophages (Mø): spleen cell ratios as low as 0.01:1. It was independent from the activation status of Mø and was not MHC restricted...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(82)80063-6
更新日期：1982-12-01 00:00:00
abstract：:The part played by MHC antigens on lymphocyte homing has been investigated by inducing modifications of their expression on lymphoid cells. A significant, though moderate, enhancement of H-2 antigen expression has been observed following in vitro treatment of lymphocytes with alpha-IFN. A decrease has been obtained af...
journal_title：Immunobiology
pub_type： 杂志文章
doi：10.1016/S0171-2985(84)80073-X
更新日期：1984-12-01 00:00:00
