当前位置： SCI文献检索 > IMMUNOBIOLOGY期刊下所有文献 > UL16 binding proteins.

UL16 binding proteins.

Abstract：

:According to present concepts, innate immunity plays an important role in tumor surveillance and immune modulation. The state of NK cells depends on the balance between inhibitory and activating signals from corresponding receptors. As one of the activating receptors, NKG2D recognises some self ligands such as MICA/B in human and Rae1 in mice, which is dissimilar to those toll-like receptors that recognise some pathogen-derived ligands. NKG2D is expressed not only on NK cells, but on gammadelta T cells, CD8+ alphabeta T cells in normal individuals and CD4+ alphabeta T cells in rheumatoid arthritis patients and plays a different role on respective cells. Whereas NKG2D can only function as a costimulatory receptor on CD8+ alphabeta T cells under the domination of alphabeta TCR in spite of a deficiency of costimulatory molecule CD28, NKG2D can directly activate NK cells even in the presence of inhibitory signals from MHC-I and corresponding receptor complexes. Experiments in mice have identified that alternative splicing produces two distinct NKG2D polypeptides that associate differentially with the DAP10 and DAP12 signaling subunits and that differential expression of these isoforms and of signaling proteins determines whether NKG2D only functions as a costimulatory receptor in the adaptive immune system (CD8+ T cells) or as both a primary recognition unit and a costimulatory receptor in the innate immune system (natural killer cells and macrophages). This review summarizes the research achievements in a new ligand family (UL16 binding proteins) of NKG2D in human and shows the possible prospects of ULBP function and application.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Cao W,He W

doi

10.1016/j.imbio.2004.04.008

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

283-90

issue

3

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(04)00054-3

journal_volume

209

pub_type

杂志文章,评审

相关文献

IMMUNOBIOLOGY文献大全
  • Correlation between effector lymphocytes in natural and antibody-mediated cytotoxicity.

    abstract：:Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxi...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：

    authors： Benczur M,Györffy G,Garam T,Varga M,Medgyesi G,Sándor M,Petranyi GG

    更新日期：1979-09-01 00:00:00

  • Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells.

    abstract：:Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effec...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2012.06.009

    authors： Worthington JJ,Fenton TM,Czajkowska BI,Klementowicz JE,Travis MA

    更新日期：2012-12-01 00:00:00

  • CD163 positive subsets of blood dendritic cells: the scavenging macrophage receptors CD163 and CD91 are coexpressed on human dendritic cells and monocytes.

    abstract：:CD163 and CD91 are scavenging receptors with highly increased expression during the differentiation of monocytes into the anti-inflammatory macrophage phenotype. In addition, CD91 is expressed in monocyte-derived dendritic cells (MoDCs), where the receptor is suggested to be important for internalization of CD91-targe...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2006.05.019

    authors： Maniecki MB,Møller HJ,Moestrup SK,Møller BK

    更新日期：2006-01-01 00:00:00

  • An evaluation of the existence of soluble suppressor factors in cloned antigen-specific T suppressor lymphocytes.

    abstract：:The suppressive activity of two bovine serum albumin-specific class II-restricted T suppressor cell clones (BVI/5 and 83/2-D11) was compared to that of a feeder cell-independent, IL 2-dependent subline (HF1.IL-2) of an originally antigen-dependent class II-restricted Ts cell clone (HF1). No soluble suppressor factors ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(87)80008-6

    authors： Bettmann R,Degwert J,Heuer J,Kölsch E

    更新日期：1987-05-01 00:00:00

  • Lidocaine inhibits epithelial chemokine secretion via inhibition of nuclear factor kappa B activation.

    abstract：AIM:To study the antiinflammatory effect of lidocaine in intestinal epithelial cells. METHODS:HT-29 and T-84 cells were grown in culture with and without TNF-alpha, lidocaine, aconitine and veratridine. The secretion of IL-8 and IP-10 was measured by ELISA. A cDNA microarray was used to assess gene expression. Real-ti...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2009.05.006

    authors： Lang A,Ben Horin S,Picard O,Fudim E,Amariglio N,Chowers Y

    更新日期：2010-04-01 00:00:00

  • Modulatory activity of Lactobacillus rhamnosus OLL2838 in a mouse model of intestinal immunopathology.

    abstract：:Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study,...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2015.01.004

    authors： Ogita T,Bergamo P,Maurano F,D'Arienzo R,Mazzarella G,Bozzella G,Luongo D,Sashihara T,Suzuki T,Tanabe S,Rossi M

    更新日期：2015-06-01 00:00:00

  • MHC- and Igh-unrestricted interaction between L3T4+, Lyt-2- Ts inducer cells and L3T4-, Lyt-2+ Ts effector cells is required for T cell-dependent suppression of DTH to histocompatibility antigens.

    abstract：:This paper describes the characteristics of T suppressor inducer (Ts ind) cells which can interact with T suppressor effector (Ts eff) cells and thereby can account for suppression of delayed-type hypersensitivity (DTH) to alloantigens. Adoptive transfer of spleen cells from mice intravenously (i.v.) injected with all...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(89)80007-5

    authors： Molendijk A,van Gurp RJ,Knulst AC,Benner R

    更新日期：1989-03-01 00:00:00

  • Anti-citrullinated protein antibodies suppress let-7a expression in monocytes from patients with rheumatoid arthritis and facilitate the inflammatory responses in rheumatoid arthritis.

    abstract：:We hypothesized that anti-citrullinated protein antibodies (ACPAs) could affect the expression of miRNAs in monocytes and contribute to the inflammatory responses in rheumatoid arthritis (RA). The expression profiles of 270 human miRNAs, co-cultured with ACPAs or human immunoglobulin G (IgG), were analyzed using real-...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2015.07.007

    authors： Lai NS,Yu HC,Yu CL,Koo M,Huang HB,Lu MC

    更新日期：2015-12-01 00:00:00

  • Differential effects of cell adherence on LPS-stimulated cytokine production by human monocytes and macrophages.

    abstract：:It is well known that adherence of monocytes (MO) to extracellular matrix substrates or tissue culture plastic activates these cells and induces the expression of a multitude of genes. Especially, it was described, that MO are primed by cell adhesion to produce higher amounts of some cytokines, e.g. interleukin (IL)-8...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(97)80069-1

    authors： Krause SW,Kreutz M,Andreesen R

    更新日期：1996-01-01 00:00:00

  • An advanced approach for the characterization of dendritic cell-induced T cell proliferation in situ.

    abstract：:It is commonly accepted that dendritic cells (DCs) play a pivotal role in the induction of adaptive T cell-mediated immune responses. The clonal expansion of antigen-specific T cells within secondary lymphoid organs reflects the efficiency of antigen processing and presentation by DCs. Consequently, the quantification...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2010.05.017

    authors： Florian C,Barth T,Wege AK,Männel DN,Ritter U

    更新日期：2010-09-01 00:00:00

  • Stimulation of human and mouse lymphocytes by ribosomal proteins.

    abstract：:Ribosomal 30S and 50S subunits as well as total proteins from the large subunit of E. coli ribosomes were found to be potent mitogens for both human adult and cord blood lymphocytes. On the other hand, the RNA fraction of the 50S subunit had only a weak stimulatory capacity suggesting that the protein moiety contains ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(80)80079-9

    authors： Sieber G,Rühl H

    更新日期：1980-01-01 00:00:00

  • Engagement of CD147 molecule-induced cell aggregation through the activation of protein kinases and reorganization of the cytoskeleton.

    abstract：:CD147 is a broadly expressed cell surface molecule of the immunoglobulin superfamily whose expression is up-regulated upon T cell activation. Engagement of CD147 by CD147 monoclonal antibodies (mAbs) has been shown to induce homotypic aggregation of U937 cells. To study intracellular signal transduction induced by the...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(01)80015-2

    authors： Khunkeawla P,Moonsom S,Staffler G,Kongtawelert P,Kasinrerk W

    更新日期：2001-05-01 00:00:00

  • All-trans retinoic acid up-regulates Prostaglandin-E Synthase expression in human macrophages.

    abstract：:All-trans retinoic acid (ATRA) is a potent retinoid, which has been used successfully in different clinical settings as a potential drug to treat COPD and emphysema. In the present study, we analyzed genes modulated by ATRA by performing mRNA expression array analysis on alveolar macrophages after treatment with ATRA....

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2011.10.022

    authors： Mamidi S,Hofer TP,Hoffmann R,Ziegler-Heitbrock L,Frankenberger M

    更新日期：2012-06-01 00:00:00

  • The role of ficolins in innate immunity.

    abstract：:Ficolins are a group of proteins containing both a collagen-like domain and a fibrinogen-like domain and are found in varying tissues. Ficolins present in sera have a lectin activity toward N-acetylglucosamine through their fibrinogen-like domains. The domain organizations between ficolins and mannose-binding lectin (...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1078/0171-2985-00149

    authors： Matsushita M,Fujita T

    更新日期：2002-09-01 00:00:00

  • Neutrophil--CD4+CD25+ T regulatory cell interactions: a possible new mechanism of infectious tolerance.

    abstract：:This study tested the hypothesis that CD4(+)CD25(+)CD127(low) regulatory T (Treg) cells might induce immunosuppressive properties in apoptotic neutrophils. Treg cells are recognized as a major subset of immune cells possessing potent suppressive properties directed at T effector cells. However, Treg cells have recentl...

    journal_title：Immunobiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.imbio.2012.05.029

    authors： Lewkowicz N,Klink M,Mycko MP,Lewkowicz P

    更新日期：2013-04-01 00:00:00

  • Predictive role of IL-17A/IL-10 ratio in persistent asthmatic patients on vitamin D supplement.

    abstract：:Asthma is an airway inflammatory disorder. Vitamin (Vit) D is a potent immuno-modulator. It suppresses Interleukin (IL)-17 and induces IL-10. This study aims to investigate the role of IL-17A and IL-10 in predicting asthma control in case of Vit D supplementation. Seventy-nine patients enrolled in this study (42 patie...

    journal_title：Immunobiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.imbio.2019.09.005

    authors： Shabana MA,Esawy MM,Ismail NA,Said AM

    更新日期：2019-11-01 00:00:00

  • Differentiation from thymic B cell progenitors to mature B cells in vitro.

    abstract：:The role of the thymic microenvironment in the development of murine thymic B cells has yet to be fully clarified. We therefore investigate the microenvironment that supports the development of mature thymic B cells (sIg+/B220+/CD43-B cells) from thymic B cell progenitors with immunophenotypes of sIg-/B220med/CD43+ ce...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(00)80071-6

    authors： Sugihara A,Inaba M,Mori SI,Taketani S,Adachi Y,Hisha H,Inaba K,Toki J,Horio T,Gershwin ME,Ikehara S

    更新日期：2000-04-01 00:00:00

  • The macrophage population of the gastro-intestinal tract of the rat.

    abstract：:The macrophage population of the gastro-intestinal tract of the rat was studied by using a set of three monoclonal antibodies (ED1, ED2 and ED3) directed against rat macrophages, an anti-Ia monoclonal antibody and by performing an acid phosphatase reaction. The lamina propria of the whole gastro-intestinal tract compr...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(86)80053-5

    authors： Sminia T,Jeurissen SH

    更新日期：1986-08-01 00:00:00

  • The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs.

    abstract：:Reggie-1/flotillin-2 is a plasma membrane-associated cytoplasmic protein, which defines non-caveolar raft microdomains. Reggie-1/flotillin-2 is enriched in detergent insoluble (TX100) membrane fractions (DIG), co-localizes with activated GPI-linked proteins and the fyn-kinase in neurons and T cells, and thus apparentl...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1078/0171-2985-00114

    authors： Solomon S,Masilamani M,Rajendran L,Bastmeyer M,Stuermer CA,Illges H

    更新日期：2002-03-01 00:00:00

  • Carbohydrate surface constituents of T cells mediating delayed-type hypersensitivity that control entry into sites of antigen deposition.

    abstract：:Peritoneal exudate T lymphocytes (PETLs) that mediate delayed-type hypersensitivity (DTH) to sheep red blood cells in mice were modified by in vitro treatment methods which modify surface carbohydrate constituents. Neuraminidase treatment resulted in the release of both N-acetylneuraminic acid and N-glycolyl-neuramini...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(81)80046-0

    authors： Kaufmann SH,Schauer R,Hahn H

    更新日期：1981-01-01 00:00:00

  • Cell wall preparation consisting of group A carbohydrate and peptidoglycan moieties from Streptococcus pyogenes activates murine B lymphocytes.

    abstract：:Cell walls from Streptococcus pyogenes strain Sv (Group A, M type 3) were lysed with M1 endo-N-acetylmuramidase, and the group A-specific carbohydrate antigen was purified by Sephadex G-100 gel filtration. The initial eluting antigen (M1gA) peak was assessed for mitogenic and polyclonal lymphocyte-activating propertie...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(85)80078-4

    authors： Morisaki I,Kimura S,Torii M,Michalek SM,McGhee JR,Okahashi N,Hamada S

    更新日期：1985-11-01 00:00:00

  • Induction of antitumor reactive cells or suppressor cells by different molecular species isolated from the same nonimmunogenic tumor.

    abstract：:The inability of spontaneous and some laboratory-induced tumors to stimulate the immune system has continuously raised the question of the validity of using immunological maneuvers in order to control tumor growth. In this project we suggest that a tumor which is nonimmunogenic still has an immunogenic potential that ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(82)80101-0

    authors： Klein BY,Sharon R,Tarcic N,Naor D

    更新日期：1982-10-01 00:00:00

  • Interaction of lipoteichoic acid and CpG-DNA during activation of innate immune cells.

    abstract：:The innate immune system recognizes pathogen-associated molecular patterns (PAMP) to cope with evolving infections. Toll-like receptors (TLRs) play a pivotal role in recognition of PAMPs. In the course of infection not a single but rather a full panel of different microbial components interacts with distinct TLRs simu...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1078/0171-2985-00189

    authors： Dalpke AH,Frey M,Morath S,Hartung T,Heeg K

    更新日期：2002-10-01 00:00:00

  • Immunofluorescence studies on the codistribution immune deposits and complement in the thyroid glands of Obese strain (OS) chickens.

    abstract：:This study demonstrates immune complexes in thyroid glands of Obese strain (OS) chickens, that consist of thyroglobulin (Tg) and antibodies to Tg. In IIF tests it was shown that these complexes fix complement with an age-dependent increase from 12% in 19-day-old embryos up to 100% in 6-week-old animals. This finding a...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(83)80035-7

    authors： Kofler H,Kofler R,Wolf H,Wick G

    更新日期：1983-05-01 00:00:00

  • Endocrine and immune system interactions during pregnancy.

    abstract：:Pregnancy is known to induce a transient depression of maternal cell-mediated immunity, to prevent rejection of the fetus, while at the same time it keeps adequate maternal host defense mechanisms to fight infection. Presently, the aim of this paper was to investigate a possible endocrine and immunologic alteration ob...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.09.005

    authors： Brazão V,Kuehn CC,dos Santos CD,da Costa CM,Júnior JC,Carraro-Abrahão AA

    更新日期：2015-01-01 00:00:00

  • Roles of cytotoxic delayed-type hypersensitivity and macrophage-activating cell-mediated immunity in the pathogenesis of tuberculosis.

    abstract：:The tubercle bacillus is a facultative intracellular parasite that grows well in non-activated macrophages. When large numbers of these bacilli have grown intracellularly within such macrophages, a cytotoxic immune response, herein called tissue-damaging (or necrotizing) delayed-type hypersensitivity (DTH), kills the ...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/S0171-2985(11)80452-3

    authors： Dannenberg AM Jr

    更新日期：1994-10-01 00:00:00

  • The diversity of circulating neutrophils in cancer.

    abstract：:Neutrophils, the most abundant leukocyte in human circulation are being more and more recognized as part of the immune reaction to cancer. In the last years, the understanding that neutrophils possess a dual role in cancer development has emerged. During tumor progression the number of neutrophils increase, and their ...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2016.02.001

    authors： Mishalian I,Granot Z,Fridlender ZG

    更新日期：2017-01-01 00:00:00

  • Elevated CD4 antigen expression among activated T cells in lymph nodes draining mammary regions chronically exposed to Staphylococcus aureus antigen.

    abstract：:We examined the cell cycle distribution and subset marker characteristics of mucosal-associated supramammary lymph node (MALN) T cell subpopulations at sites proximal and distal to the mammary region of animals repeatedly injected with Staphylococcus aureus antigen. Multiparameter flow cytometric analysis of draining ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80317-7

    authors： Dobrzanski MJ,Yang TJ

    更新日期：1992-06-01 00:00:00

  • Distinctive Treg associated CCR4-CCL22 expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris.

    abstract：:Pemphigus Vulgaris (PV), a relatively common autoimmune blistering disease in India, primarily mediated by anti-Desmoglein 3 (anti-Dsg3) autoantibodies. T-helper 17 (Th17) and T-regulatory (Treg) cells play significant role in regulating immune homeostasis in autoimmune disorders. To understand immunopathogenesis of P...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2015.06.008

    authors： Asothai R,Anand V,Das D,Antil PS,Khandpur S,Sharma VK,Sharma A

    更新日期：2015-10-01 00:00:00

  • Human dendritic cells express functional interleukin-7.

    abstract：:Interleukin-7 (IL-7) supports the proliferation of mature T lymphocytes, however, the cellular source of IL-7 for T lymphocyte activation has not been well established. We therefore investigated whether human peripheral blood dendritic cells (DC) produce IL-7 as a contribution towards T lymphocyte activation. Human CM...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(98)80075-2

    authors： Sorg RV,McLellan AD,Hock BD,Fearnley DB,Hart DN

    更新日期：1998-03-01 00:00:00