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Regulation of TGFβ in the immune system: an emerging role for integrins and dendritic cells.

Abstract：

:Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effects on many different cells of the immune system, and plays fundamental roles in the regulation of immune responses during homeostasis, infection and disease. Although many cells can produce TGFβ, it is always produced as an inactive complex that must be activated to bind to the TGFβ receptor complex and promote downstream signalling. Thus, regulation of TGFβ activation is a crucial step in controlling TGFβ function. This review will discuss how TGFβ controls diverse immune responses and how TGFβ function is regulated, with a focus on recent work highlighting a critical role for the integrin αvβ8 expressed by dendritic cells in activating TGFβ.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Worthington JJ,Fenton TM,Czajkowska BI,Klementowicz JE,Travis MA

doi

10.1016/j.imbio.2012.06.009

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

1259-65

issue

12

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(12)00149-0

journal_volume

217

pub_type

杂志文章,评审

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