Abstract：
:In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating evidence came to light about the discrepancy in the apoptosis sensitivity and GR expression of thymocytes and other lymphoid cell types. Herein, we attempt to sample the latest information in the field of non-genomic GC signalling in T cells, and correlate it with results from our laboratory. We discuss some aspects of the regulation of thymocyte apoptosis by GCs, paying special interest to the potential role(s) of mitochondrial GR signalling. The interplay between the T cell receptor (TcR) and glucocorticoid receptor (GR) signalling pathways is described in more detail, focusing on ZAP-70, which is a novel target of rapid GC action.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Boldizsar F,Talaber G,Szabo M,Bartis D,Palinkas L,Nemeth P,Berki Tdoi
10.1016/j.imbio.2009.10.003subject
Has Abstractpub_date
2010-07-01 00:00:00pages
521-6issue
7eissn
0171-2985issn
1878-3279pii
S0171-2985(09)00167-3journal_volume
215pub_type
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