Spontaneous and conA-induced suppressor lymphocytes: a comparative study.

abstract：:Recently, it could be shown that Cyclosporin A (CsA) inhibited the activation of T and B lymphocytes by interfering with an early step of the activation, namely the stimulation of the plasma membrane-bound lysophosphatide acyltransferase. In this report, we compared three CsA-derivatives, Dihydro-Cyclosporin C (Dihydr...

journal_title：Immunobiology

authors： Kroggel R,Goppelt-Strübe M,Martin M,Resch K

更新日期：1987-09-01 00:00:00

abstract：:Supernatants from Concanavalin A-stimulated murine spleen cells were subjected to hydrophobic interaction chromatography on phenyl-Sepharose. Macrophage cytotoxicity factor (MCF), macrophage migration inhibitory factor (MIF), T-helper cell-replacing factor (TRF) and colony-stimulating factor (CSF) were bound at high i...

journal_title：Immunobiology

authors： Hübner L,Kniep EM,Laukel H,Sorg C,Fischer H,Gassel WD,Havemann K,Kickhöfen B,Lohmann-Matthes ML,Schimpl A,Wecker E

更新日期：1980-07-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Immunobiology

authors： Luo HL,Wang DY,Wang HJ,Nie K,Huang WY

更新日期：2011-12-16 00:00:00

abstract：:CD40 is essential for optimal B cell activation. It has been shown that CD40 stimulation can augment BCR-induced B cell responses, but the molecular mechanism(s) by which CD40 regulates BCR signaling is poorly understood. In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated...

journal_title：Immunobiology

authors： Ying H,Li Z,Yang L,Zhang J

更新日期：2011-05-01 00:00:00

abstract：:The CD300 glycoproteins are a family of related leucocyte surface molecules that modulate a diverse array of cell processes via their paired triggering and inhibitory receptor functions. All family members have a single Ig-V like domain and they share a common evolutionary pathway. At least one member of the family ha...

journal_title：Immunobiology

authors： Clark GJ,Ju X,Azlan M,Tate C,Ding Y,Hart DN

更新日期：2009-01-01 00:00:00

abstract：:L-alanine was shown earlier to play a significant role for the proliferation of lymphocytes in vitro. In the present work the effect of L-alanine and some other amino acids on thymocyte proliferation was studied in vivo by local administration into one thymus lobe of guinea pigs. Proliferating cells were pulse labelle...

journal_title：Immunobiology

authors： Hägglund B,Sandberg G

更新日期：1993-06-01 00:00:00

abstract：:We investigated the effects of ML I and its isolated chains, A and B, in regard to selected functions of phagocytes (human granulocytes, paraffin-oil stimulated M phi from guinea pigs). On these cells, ML I has no cytotoxic effect between 10(-14) and 10(-8) (trypan blue exclusion and ethidium bromide exclusion). Over ...

journal_title：Immunobiology

authors： Metzner G,Franz H,Kindt A,Fahlbusch B,Süss J

更新日期：1985-07-01 00:00:00

abstract：:Trypanosoma cruzi is a real challenge to the host's immune system, because it requires strong humoral and cellular immune response to remove circulating trypomastigote forms, and to prevent the replication of amastigote forms in tissues, involving many regulator and effector components. This protozoan is responsible f...

journal_title：Immunobiology

authors： Basso B,Marini V

更新日期：2015-03-01 00:00:00

abstract：:Gammaherpesviruses (gammaHV) establish a life-long latency in the host and are associated with a number of malignant human diseases. It is generally believed that T cells play a major role in controlling the initial acute infection and subsequently maintaining the virus in a quiescent state. However, the nature of the...

journal_title：Immunobiology

authors： Woodland DL,Flaño E,Usherwood EJ,Liu Luzheng,Kim IJ,Husain SM,Sample JT,Blackman MA

更新日期：2001-12-01 00:00:00

abstract：:Cell walls from Streptococcus pyogenes strain Sv (Group A, M type 3) were lysed with M1 endo-N-acetylmuramidase, and the group A-specific carbohydrate antigen was purified by Sephadex G-100 gel filtration. The initial eluting antigen (M1gA) peak was assessed for mitogenic and polyclonal lymphocyte-activating propertie...

journal_title：Immunobiology

authors： Morisaki I,Kimura S,Torii M,Michalek SM,McGhee JR,Okahashi N,Hamada S

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:The soluble form of the haptoglobin-hemoglobin (Hp-Hb) scavenger receptor (sCD163) is a specific plasma/serum marker for macrophage activity. Here, we have characterized molecular forms in serum and investigated a role of sCD163 as a binder of Hp-Hb complexes. METHODS:The sCD163 species in serum (from 50 he...

journal_title：Immunobiology

authors： Møller HJ,Nielsen MJ,Maniecki MB,Madsen M,Moestrup SK

更新日期：2010-05-01 00:00:00

abstract：:Anti-anaemic drug ferric-sorbitol citrate showed immunomodulatory effects, activating NF-kappaB in peritoneal macrophages, which consequently secrete tumour necrosis factor-alpha (TNF-alpha). TNF-alpha activates NF-kappaB in spleen cells. The aim of this study was to investigate the effect of iron polyisomaltosate, an...

journal_title：Immunobiology

authors： Poljak-Blazi M,Jaganjac M,Mustapic M,Pivac N,Muck-Seler D

更新日期：2009-01-01 00:00:00

abstract：:Dendritic cells (DCs) are potent antigen-presenting cells that initiate the primary immune response and whose functional properties in vivo depend on the maturation stimulus. We describe the functional properties of human monocyte-derived DCs after the maturation of immature DCs (iDCs) for 2 days with LPS (100 ng/ml),...

journal_title：Immunobiology

authors： da Silva I,Gomes GG,Menezes CC,Palma PV,Orellana MD,Covas DT,Chammas R,Greene LJ

更新日期：2013-02-01 00:00:00

abstract：:Soluble MHC antigens are detected in body fluids but their role and origin are still unclear. This study examined whether serum IA antigens, isolated from BALB/c mice (sIA(d)), could modulate the immune response. Specific purification procedures isolated intact IA molecules, which were thereafter applied to functional...

journal_title：Immunobiology

authors： Marios-Frankiskos S,Panagiota M,Katerina B,Athanassakis I

更新日期：2010-03-01 00:00:00

abstract：:When monocytes are stimulated with LPS (lipopolysaccharide) repeatedly then the initially high expression of the TNF (tumor necrosis factor) gene is only very low, i.e. the cells are tolerant to LPS. Tolerant cells still express the CD14 receptor and they can still be activated to mobilize NF-kappa B into nucleus. Ana...

journal_title：Immunobiology

authors： Frankenberger M,Ziegler-Heitbrock HW

更新日期：1997-12-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is a primary immunodeficiency caused by impaired Fas/FasL-mediated apoptosis of lymphocytes and is characterized by chronic nonmalignant or benign lymphoproliferation, autoimmune manifestations and expansion of double negative (DN) T-cells (TCRαβ+CD4-CD8-). Most cases of ...

journal_title：Immunobiology

authors： Martínez-Feito A,Melero J,Mora-Díaz S,Rodríguez-Vigil C,Elduayen R,González-Granado LI,Pérez-Méndez D,Sánchez-Zapardiel E,Ruiz-García R,Menchén M,Díaz-Madroñero J,Paz-Artal E,Del Orbe-Barreto R,Riñón M,Allende LM

更新日期：2016-01-01 00:00:00

abstract：:The role of the thymic microenvironment in the development of murine thymic B cells has yet to be fully clarified. We therefore investigate the microenvironment that supports the development of mature thymic B cells (sIg+/B220+/CD43-B cells) from thymic B cell progenitors with immunophenotypes of sIg-/B220med/CD43+ ce...

journal_title：Immunobiology

authors： Sugihara A,Inaba M,Mori SI,Taketani S,Adachi Y,Hisha H,Inaba K,Toki J,Horio T,Gershwin ME,Ikehara S

更新日期：2000-04-01 00:00:00

abstract：:We studied local events in the popliteal lymph nodes of CD4-deficient mice following foot pad injection with an MMTV strain which carries the gene for a V beta 14-specific superantigen. Injection of the V beta 14-specific MMTV induced vigorous expansion of V beta 14+ CD4+ T cells and B cells in their lymph nodes of CD...

journal_title：Immunobiology

authors： Ando Y,Wajjwalku W,Kishihara K,Arai T,Niimi N,Hiromatsu K,Morishima T,Yoshikai Y

更新日期：1996-08-01 00:00:00

abstract：:CD4(+)CD25(+)Foxp3(+) T regulatory cells (Tregs) and CD1d-restricted invariant natural killer T (iNKT) cells are two cell types that are known to regulate immune reactions. Depletion or inactivation of Tregs using specific anti-CD25 antibodies in combination with immunostimulation is an attractive modality especially ...

journal_title：Immunobiology

authors： Rosalia RA,Štěpánek I,Polláková V,Šímová J,Bieblová J,Indrová M,Moravcová S,Přibylová H,Bontkes HJ,Bubeník J,Sparwasser T,Reiniš M

更新日期：2013-06-01 00:00:00

abstract：:Canine visceral leishmaniasis (CVL) is known to affect the cellular immunity of infected dogs, through impairing lymphoproliferation and microbicidal mechanisms. This study examined heme oxygenase-1 (HO-1) and its metabolites, oxidative stress and IL-10 levels in CVL and investigated correlations between these paramet...

journal_title：Immunobiology

authors： Almeida BF,Silva KL,Chiku VM,Leal AA,Venturin GL,Narciso LG,Fink MF,Eugênio FR,Santos PS,Ciarlini PC,Lima VM

更新日期：2017-05-01 00:00:00

abstract：:MHC class II molecules presenting MHC class II restricted antigens play an important role in the activation of CD4+ T cells, which are the central orchestrating cells of an immune response. This review focuses on the particular role of MHC class II molecules in tumour immunology. The MHC class II antigen presentation ...

journal_title：Immunobiology

authors： Chamuleau ME,Ossenkoppele GJ,van de Loosdrecht AA

更新日期：2006-01-01 00:00:00

abstract：:Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...

journal_title：Immunobiology

authors： Joncourt F,Bettens F,Kristensen F,de Weck AL

更新日期：1981-06-01 00:00:00

abstract：:CD45RA monoclonal antibodies recognize the higher molecular weight isoforms (220 and 205 kDa) of leukocyte common antigen family (CD45), which are typically expressed on B cells and unstimulated T cells. We have found that there are at least three distinct CD45RA monoclonal antibodies which react with platelet 42 kDa ...

journal_title：Immunobiology

authors： Holada K,Dyr JE,Koubek K,Suttnar J,Simák J

更新日期：1995-02-01 00:00:00

abstract：:Surfactant proteins SP-A and SP-D are pattern recognition innate immune molecules that belong to the C-type lectin family. In lungs, they play an important role in the clearance of pathogens and control of inflammation. SP-A and SP-D are also expressed in the female reproductive tract where they play an important role...

journal_title：Immunobiology

authors： Madhukaran SP,Koippallil Gopalakrishnan AR,Pandit H,Marri ED,Kouser L,Jamil K,Alhamlan FS,Kishore U,Madan T

更新日期：2016-02-01 00:00:00

abstract：:In an immunohistochemical study using monoclonal antibodies, which exclusively recognize cells of the monocyte-macrophage lineage, and monoclonal antibodies against the Ia-antigen, we describe the occurrence of macrophages in the developing and adult central nervous system (CNS). In normal adult brain, no macrophages ...

journal_title：Immunobiology

authors： Sminia T,de Groot CJ,Dijkstra CD,Koetsier JC,Polman CH

更新日期：1987-01-01 00:00:00

abstract：:Immunocytochemical studies on both the light-microscopic and electron-microscopic levels proved that peritoneal resident macrophages derive from a precursor cell in the bone marrow. Evidence that this precursor cell differs from that of the monocyte is described. Progenitor cells of peritoneal resident macrophages wer...

journal_title：Immunobiology

authors： Daems WT,de Bakker JM

更新日期：1982-04-01 00:00:00

abstract：:In a subgroup of CVID T cell abnormalities have been reported. Peripheral blood T lymphocytes from patients with common variable immunodeficiency (CVID) and blood donors were examined for expression of CD8alpha, CD8beta and CD28. In CVID, three CD8+ T cells could be defined: CD8beta(high)CD28+ (expressing CD8beta at a...

journal_title：Immunobiology

authors： Werwitzke S,Drescher B,Schmidt RE,Witte T

更新日期：2000-08-01 00:00:00

abstract：:Human urinary colony-stimulating factor (CSF-HU) has been partially purified using five purification procedures (preparation II) for clinical use. In phase I study, six healthy volunteers were injected with preparation II of CSF-HU by a single intravenous droplet infusion. Two volunteers received 4 X 10(6) units (U), ...

journal_title：Immunobiology

authors： Motoyoshi K,Ishizaka Y,Miura Y,Takaku F

更新日期：1986-09-01 00:00:00

abstract：:Leukocytes found at the human maternal-fetal interface participate in the inflammatory process associated with both preterm and term labor; therein, effective methods for their isolation that allow further phenotypic and functional analyses are necessary. Leukocyte isolation is usually carried out through scraping or ...

journal_title：Immunobiology

authors： MacDonald-Ramos K,Arenas-Hernandez M,Mancilla-Herrera I,Rangel-Escareño C,Vega-Sanchez R

更新日期：2019-01-01 00:00:00

abstract：:By quantitative and functional methods, changes were assessed in NK(ASGM-1+) cell numbers and NK cell-mediated lytic function of the spleen and bone marrow of mice bearing a tumor of hemopoietic origin (FLV-induced erythroleukemia) for 9 days +/- simultaneous administration of indomethacin (10 micrograms/ml drinking w...

journal_title：Immunobiology

authors： Christopher FL,Dussault I,Miller SC

更新日期：1991-12-01 00:00:00