The CD300 molecules regulate monocyte and dendritic cell functions.

abstract：:Five mouse hybridoma cell lines producing monoclonal antibody against bovine luteinizing hormone (LH) have been established and the respective antibodies characterized by radioimmunoassay, immunofluorescence and immunoelectrophoresis. All antibodies belong to the IgG class and bind to staphylococcus protein A. Intrasp...

journal_title：Immunobiology

authors： Kofler R,Kalchschmid E,Berger P,Wick G

更新日期：1981-01-01 00:00:00

abstract：:Blood dendritic cell precursors (DCps) are identified as mononuclear leukocytes expressing HLA-DR but lacking the characteristic antigens associated with T cells (CD3), NK cells (CD16 and CD56) and B cells (CD 19). Dendritic cell precursors are distinguished from monocytes by their lack of expression of CD64 rather th...

journal_title：Immunobiology

authors： Macey MG,Jawad N,McCarthy DA,Newland AC,Brown KA

更新日期：2000-05-01 00:00:00

abstract：:Toxoplasma gondii is a widespread protozoan parasite that causes severe disease only in immunocompromised individuals. Equipped with excellent animal models and relatively advanced systems for genetics, T. gondii provides an excellent system for understanding pathogenesis. Resistance to toxoplasmosis is governed by ra...

journal_title：Immunobiology

authors： Sibley LD,Mordue D,Howe DK

更新日期：1999-12-01 00:00:00

abstract：:The distribution of membrane-associated nucleotide pyrophosphatase activity has been investigated on mouse leucocytes of different origin. It is shown that enzyme-specific activity is higher on bone-marrow cells than on cells derived from peripheral organs. Since thymus lymphocytes show the lowest activity, it is obvi...

journal_title：Immunobiology

authors： Brockhaus A,Bösing-Schneider R,Sund H

更新日期：1982-01-01 00:00:00

abstract：:Anti-anaemic drug ferric-sorbitol citrate showed immunomodulatory effects, activating NF-kappaB in peritoneal macrophages, which consequently secrete tumour necrosis factor-alpha (TNF-alpha). TNF-alpha activates NF-kappaB in spleen cells. The aim of this study was to investigate the effect of iron polyisomaltosate, an...

journal_title：Immunobiology

authors： Poljak-Blazi M,Jaganjac M,Mustapic M,Pivac N,Muck-Seler D

更新日期：2009-01-01 00:00:00

abstract：:A cyclophosphamide (CP)-induced tolerance system in mice that primarily consists of donor cell injection followed by CP-treatment was found useful for inducing a long-lasting allo- or xeno-tolerance to various solid organs. In the cells-followed-by-CP system, the sequential mechanisms of tolerance were clarified using...

journal_title：Immunobiology

authors： Mayumi H,Umesue M,Nomoto K

更新日期：1996-07-01 00:00:00

abstract：:In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to S...

journal_title：Immunobiology

authors： Trück J,Lazarus R,Clutterbuck EA,Bowman J,Kibwana E,Bateman EA,Pollard AJ

更新日期：2013-03-01 00:00:00

abstract：:Activated macrophages have various characteristics in common with exudate and resident macrophages, but the ability to inhibit intracellular proliferation of the protozoa Toxoplasma gondii, the expression of Ia antigen and the capacity to produce H2O2 varies among these cells. Assessment of these features of macrophag...

journal_title：Immunobiology

authors： Nibbering PH,Langermans JA,van de Gevel JS,van der Hulst MB,van Furth R

更新日期：1991-12-01 00:00:00

abstract：:Gammaherpesviruses (gammaHV) establish a life-long latency in the host and are associated with a number of malignant human diseases. It is generally believed that T cells play a major role in controlling the initial acute infection and subsequently maintaining the virus in a quiescent state. However, the nature of the...

journal_title：Immunobiology

authors： Woodland DL,Flaño E,Usherwood EJ,Liu Luzheng,Kim IJ,Husain SM,Sample JT,Blackman MA

更新日期：2001-12-01 00:00:00

abstract：:The mechanisms of tolerance induction occurring in the course of allergen-specific immunotherapy have not been elucidated in full detail. Our study aimed to characterize high zone tolerance in mouse models of type I allergy and of allergic airway inflammation induced by subcutaneous sensitization of mice with high dos...

journal_title：Immunobiology

authors： Raker V,Stein J,Montermann E,Maxeiner J,Taube C,Reske-Kunz AB,Sudowe S

更新日期：2015-04-01 00:00:00

abstract：:Cytokines are important mediators of the effects observed after the administration of endotoxin. One of them, tumor necrosis factor, is particularly important since it plays a cardinal role in two major endotoxin activities: its antitumor effect and its capacity to induce a systemic inflammatory response syndrome. TNF...

journal_title：Immunobiology

authors： Brouckaert P,Libert C,Everaerdt B,Takahashi N,Cauwels A,Fiers W

更新日期：1993-04-01 00:00:00

abstract：:Monoclonal mouse anti-Thy-1.2 antibody of IgG3 isotype (MTA) inhibits in a significant and long-term manner the regional graft-versus-host reaction (GVHR) when administered to donors as well as to recipients. The process of sensitization in the reaction of delayed type hypersensitivity to SRBC (DTH) is, on the other h...

journal_title：Immunobiology

authors： Sůla K,Sobotková E,Svobodová M,Nouza K

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs. OBJECTIVES:The present study investigates the association between immune response and decline in lung function...

journal_title：Immunobiology

authors： Wölbeling F,Munder A,Kerber-Momot T,Neumann D,Hennig C,Hansen G,Tümmler B,Baumann U

更新日期：2011-08-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Immunobiology

authors： Luo HL,Wang DY,Wang HJ,Nie K,Huang WY

更新日期：2011-12-16 00:00:00

abstract：:The humoral immune response against alpha(1-->3) dextran (Dex) in BALB/c mice is characterized by the formation of predominantly IgM antibodies bearing the J558 idiotype. IgG antibodies do not appear in euthymic mice. In athymic animals, however, the response proceeds to a vigorous IgG production. In euthymic mice for...

journal_title：Immunobiology

authors： Specht C,Junker R,Krüger A,Rademaekers A,Redlich H,Kölsch E

更新日期：1999-09-01 00:00:00

abstract：:The collectins are a group of innate immune proteins structurally characterized by their content of a carbohydrate recognition domain and a collagen-like region. Collectin liver 1 (CL-L1) and collectin 11 (CL-11, alias collectin kidney 1, CL-K1) are the more recently described members of this group. Their genomic orga...

journal_title：Immunobiology

authors： Selman L,Hansen S

更新日期：2012-09-01 00:00:00

abstract：:"Brucelline INRA" is an aqueous extract of a rough strain of Brucella melitensis that is used to test cutaneous delayed hypersensitivity in man and animals. The cellular response of mice (either normal, or sensitized by a previous brucella infection) was investigated with local implanted "cell-traps" and by immunologi...

journal_title：Immunobiology

authors： Bureau JP,Caravano R,Garelli L,Lemaire J

更新日期：1989-03-01 00:00:00

abstract：:We studied immunohistological and biochemical aspects of the CD44 molecule with a mAb produced in our lab: GRHL-1. The characteristic expression of this antigen in cells of B lineage was analyzed. This mAb showed identical immunohistological patterns of reactivity to other mAbs included in CD44 cluster, on a variety l...

journal_title：Immunobiology

authors： Collado A,de Andres A,Cañadas E,Ruiz-Cabello F,Gomez O,Pedrinaci S,Garrido F

更新日期：1991-09-01 00:00:00

abstract：:Suppressor monocytes, Concanavalin A(ConA)-induced suppressor T cells, and short-lived suppressor lymphocytes have been describe in humans. The present study was performed to evaluate spontaneous suppression in a test system similar to that employed for the demonstration of ConA-induced suppressor cells: Lymphocytes w...

journal_title：Immunobiology

authors： Gattringer C,Huber H,Michlmayr G,Braunsteiner H

更新日期：1981-01-01 00:00:00

abstract：:IFN-γ produced during viral infections activates the IFN-γ receptor (IFNGR) complex for STAT1 transcriptional activity leading to expression of Interferon Regulatory Factors (IRF). Simultaneous activation of TBK/IKKε via TLR3 during viral infections activates the transcription factor IRF3. Together these transcription...

journal_title：Immunobiology

authors： Guinn ZP,Petro TM

更新日期：2019-07-01 00:00:00

abstract：:Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile...

journal_title：Immunobiology

authors： Bonura A,Vlah S,Longo A,Bulati M,Melis MR,Cibella F,Colombo P

更新日期：2016-12-01 00:00:00

abstract：:C1q binds to immune complexes to elicit complement-dependent microbial killing and enhance phagocytosis. Besides this classical role, C1q also opsonizes apoptotic cells for clearance by phagocytes. C1q deficiency increases susceptibility to microbial infections and is also associated with elevated autoimmunity as char...

journal_title：Immunobiology

authors： Lu J,Wu X,Teh BK

更新日期：2007-01-01 00:00:00

abstract：:Fifty-nine patients with metastatic malignant melanoma were entered into a phase II trial of recombinant alpha-2 interferon given in a dosage of 10 million IU/M2 subcutaneously three times per week for one year. Forty-five of these were evaluable for response. Of five evaluable patients with ocular primaries, none res...

journal_title：Immunobiology

authors： Robinson WA,Mughal TI,Thomas MR,Johnson M,Spiegel RJ

更新日期：1986-09-01 00:00:00

abstract：:Considering that imbalance of central tolerance in the thymus contributes to aggressive autoimmunity, we compared the expression of peripheral tissue autoantigens (PTA) genes, which are involved in self-representation in the thymic stroma, of two mouse strains; DBA-1/J (MHC-H2(q)) susceptible and DBA-2/J (MHC-H2(d)) r...

journal_title：Immunobiology

authors： Donate PB,Fornari TA,Junta CM,Magalhães DA,Macedo C,Cunha TM,Nguyen C,Cunha FQ,Passos GA

更新日期：2011-05-01 00:00:00

abstract：:To investigate the role of IL-13 during a severe systemic Candida albicans infection, BALB/c control and IL-13-/- mice were examined for colony forming units (CFU) in the kidneys and survival days after intravenous infection. Proinflammatory mediators and cell recruitment into the tissue were measured by quantitative ...

journal_title：Immunobiology

authors： Abe Y,Yamamoto N,Nakamura K,Arai K,Sakurai C,Hatsuzawa K,Ogura Y,Iseki K,Tase C,Kanemitsu K

更新日期：2019-01-01 00:00:00

abstract：:In the thymus of non-obese diabetic (NOD) mice, the expression of the autoimmune regulator (Aire) gene varies with age, and its down-regulation in young mice precedes the later emergence of type 1 diabetes mellitus (T1D). In addition, the insulin (Ins2) peripheral tissue antigen (PTA) gene, which is Aire-dependent, is...

journal_title：Immunobiology

authors： Oliveira EH,Macedo C,Donate PB,Almeida RS,Pezzi N,Nguyen C,Rossi MA,Sakamoto-Hojo ET,Donadi EA,Passos GA

更新日期：2013-01-01 00:00:00

abstract：:Regulatory properties of macrophages associated with alternative activation serve to limit the exaggerated inflammatory response during pneumonia caused by Pseudomonas aeruginosa infection. Arginase-1 is an important effector of these macrophages believed to play an essential role in decreasing injury and promoting re...

journal_title：Immunobiology

authors： Haydar D,Gonzalez R,Garvy BA,Garneau-Tsodikova S,Thamban Chandrika N,Bocklage TJ,Feola DJ

更新日期：2020-11-24 00:00:00

abstract：:A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3d...

journal_title：Immunobiology

authors： Ling NR,Brown B

更新日期：1992-08-01 00:00:00

abstract：:Porphyromonas gingivalis 381 lipid A induced strong mitogenic response in splenic B cells separated from LPS-non-responsive C3H/HeJ mice as well as LPS-responsive C3H/HeN mice, by using a magnetic cell sorting system. The lipid A also exhibited mitogenic activity in splenic T cells. P. gingivalis lipid A induced lower...

journal_title：Immunobiology

authors： Ogawa T,Shimauchi H,Uchida H,Mori Y

更新日期：1996-01-01 00:00:00

abstract：:Human sera enhanced spontaneous cell-mediated cytotoxicity (SCMC), while anti-IgG (Fab') 2 treatment decreased this cytotoxic activity of human lymphocytes for an in vitro growing cell line (K--562). Trypsin treatment of the effector cells considerably decreased the cytotoxic potential. However, a significant cytotoxi...

journal_title：Immunobiology

authors： Benczur M,Györffy G,Garam T,Varga M,Medgyesi G,Sándor M,Petranyi GG

更新日期：1979-09-01 00:00:00