Abstract:
:Blood dendritic cell precursors (DCps) are identified as mononuclear leukocytes expressing HLA-DR but lacking the characteristic antigens associated with T cells (CD3), NK cells (CD16 and CD56) and B cells (CD 19). Dendritic cell precursors are distinguished from monocytes by their lack of expression of CD64 rather than of CD14. This study investigated whether CD14- DCps differed from CD64-DCps, which were predominantly CD14+, in their expression of five well-characterised adhesion molecules. There were significantly fewer cells expressing CD11b, CD18 and CD29 in the CD64-DCp population compared with CD14- DCps, and this CD64- DCp subpopulation also had a lower expression of CD11b and CD18. Our results suggest that the two DC precursor subpopulations may differ from one another in their binding characteristics to blood vessel walls and to other leukocytes.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Macey MG,Jawad N,McCarthy DA,Newland AC,Brown KAdoi
10.1016/S0171-2985(00)80053-4subject
Has Abstractpub_date
2000-05-01 00:00:00pages
59-67issue
1eissn
0171-2985issn
1878-3279pii
S0171-2985(00)80053-4journal_volume
202pub_type
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