Abstract:
:The lymphotoxin beta receptor (LTbetaR) mediates crucial signals in host defense against intracellular bacteria and viruses. Mice deficient in LTbetaR readily succumb to infections with Listeria monocytogenes, Mycobacterium tuberculosis and murine cytomegalovirus (mCMV). LTbetaR has been shown to be important for the early induction of interferon (IFN) beta after infection with mCMV. However, up to now, it is not known which host effector molecules are induced in cells of the innate immune system after bacterial infections. In order to address this question, comprehensive transcriptome profiling of LTbetaR-deficient and control splenocytes depleted from T and B lymphocytes was performed and differentially regulated genes were identified. Interestingly, a deficiency in IFNalpha- and IFNgamma-mRNA transcription could be found in LTbetaR-deficient cells leading to a marked failure in the immediate up-regulation of IFN controlled genes. These encompass interferon regulatory factors (IRF1 and IRF7), signal transducer activator of transcription (STAT) proteins (STAT1 and STAT2), chemokines, IFN regulated GTPases (IRGs, GBPs), and IFN-induced protein with tetratricopeptide repeats (IFITs). Thus, the immediate LTbetaR-initiated transcriptional response of innate immune cells carries an IFN signature and is responsible for mounting an effective innate immune response to L. monocytogenes.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Kutsch S,Degrandi D,Pfeffer Kdoi
10.1016/j.imbio.2007.10.011subject
Has Abstractpub_date
2008-01-01 00:00:00pages
353-66issue
3-4eissn
0171-2985issn
1878-3279pii
S0171-2985(07)00132-5journal_volume
213pub_type
杂志文章相关文献
IMMUNOBIOLOGY文献大全abstract::CD45RA monoclonal antibodies recognize the higher molecular weight isoforms (220 and 205 kDa) of leukocyte common antigen family (CD45), which are typically expressed on B cells and unstimulated T cells. We have found that there are at least three distinct CD45RA monoclonal antibodies which react with platelet 42 kDa ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(11)80103-8
更新日期:1995-02-01 00:00:00
abstract:PROBLEM:NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. METHODS OF STUDY:Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present stud...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2013.09.002
更新日期:2014-03-01 00:00:00
abstract::A glycoprotein from human erythrocyte membranes has been found to inhibit lysis of target cells by the attack-phase components C5-C9 from human complement. The inhibiting molecule was purified and identified as glycophorin A. Thus, glycophorin A may have a regulatory function in the lytic complement attack on isologou...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(83)80053-9
更新日期:1983-08-01 00:00:00
abstract::We investigated the effects of ML I and its isolated chains, A and B, in regard to selected functions of phagocytes (human granulocytes, paraffin-oil stimulated M phi from guinea pigs). On these cells, ML I has no cytotoxic effect between 10(-14) and 10(-8) (trypan blue exclusion and ethidium bromide exclusion). Over ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(85)80002-4
更新日期:1985-07-01 00:00:00
abstract::Non-antigen-specific activation of human B lymphocytes for IgE production in vitro requires the presence of interleukin 4 and non-cognate physical interaction with T cells. The latter can be replaced by antibodies directed against the B cells' CD40 structure. Antigen-specific induction of immunoglobulin responses, inc...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80234-2
更新日期:1993-07-01 00:00:00
abstract::Pemphigus Vulgaris (PV), a relatively common autoimmune blistering disease in India, primarily mediated by anti-Desmoglein 3 (anti-Dsg3) autoantibodies. T-helper 17 (Th17) and T-regulatory (Treg) cells play significant role in regulating immune homeostasis in autoimmune disorders. To understand immunopathogenesis of P...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.06.008
更新日期:2015-10-01 00:00:00
abstract::The T effector lymphocytes of delayed type hypersensitivity reactions (TDH) are regulated by a complex T suppressor (Ts) cell circuit. Induction of TDH cells requires Ia+ adherent cells as antigen-presenting cells. Little is known about the antigen presentation of the induction of Ts cells. We describe an experimental...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(84)80114-X
更新日期:1984-12-01 00:00:00
abstract::Attenuating the sepsis-induced systemic inflammatory response, with subsequent homeostatic imbalance, has for years been one of the main tasks in sepsis related research. Complement and the TLR family constitute two important upstream sensor and effector-systems of innate immunity. Although they act as partly independ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2012.07.019
更新日期:2012-11-01 00:00:00
abstract::Although there have been numerous attempts to develop a successful vaccine against leishmaniasis, based on the clinical trial in this field, no vaccine against Leishmania in routine way can be found for globally effective vaccination in human. Amongst, first generation vaccines consisting of parasite fractions or whol...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.12.003
更新日期:2018-01-01 00:00:00
abstract::In bitches, the onset of pyometra, an infection of the uterus, characteristically occurs in the first half of the diestrous stage in the estrous cycle, in which the blood concentration of progesterone peaks and that of estradiol-17beta is lowest. To investigate the immunological mechanisms governing stage-specific ons...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2004.09.003
更新日期:2004-01-01 00:00:00
abstract::The distribution of membrane-associated nucleotide pyrophosphatase activity has been investigated on mouse leucocytes of different origin. It is shown that enzyme-specific activity is higher on bone-marrow cells than on cells derived from peripheral organs. Since thymus lymphocytes show the lowest activity, it is obvi...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80029-X
更新日期:1982-01-01 00:00:00
abstract::A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3d...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80656-X
更新日期:1992-08-01 00:00:00
abstract::The aim of the work was to justify the use of trifluoromethyl-dinitrobenzene sulfonate (CF3-DNBS) modification rather than trinitrobenzene-sulfonate (TNBS) modification, so as to be able to take advantage of the presence of fluorine atoms in the analogue, which allow the analysis of the hapten-carrier bonds by 19F-NMR...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(83)80012-6
更新日期:1983-02-01 00:00:00
abstract::Considering that imbalance of central tolerance in the thymus contributes to aggressive autoimmunity, we compared the expression of peripheral tissue autoantigens (PTA) genes, which are involved in self-representation in the thymic stroma, of two mouse strains; DBA-1/J (MHC-H2(q)) susceptible and DBA-2/J (MHC-H2(d)) r...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.09.007
更新日期:2011-05-01 00:00:00
abstract::Individuals infected with Strongyloides stercoralis have been reported to produce different immunoglobulins isotypes, yet few studies have evaluated their use in strongyloidiasis diagnosis. The aim of this work was to evaluate the immunoreactivity of different classes and subclasses of anti-S. stercoralis circulating ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2019.151898
更新日期:2020-03-01 00:00:00
abstract::By fusion of C3H/HeJ splenic adherent mononuclear cells enriched for macrophages with HPRT-deficient C57L/J HH- hepatoma cells, we have generated six macrophage-hepatoma hybrid clones. The hybrid nature of isolated clones was demonstrated by karyotypic analysis. The hybrid clones were screened for macrophage propertie...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(87)80017-7
更新日期:1987-08-01 00:00:00
abstract::Dendritic cells (DCs) play a key role in the orchestration of the immune system by virtue of their capacity to control both immunity and tolerance induction. The functions of DCs depend on the subset as well as their location and activation state. A number of in vitro protocols, developed to recapitulate DC generation...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2008.07.017
更新日期:2008-01-01 00:00:00
abstract::A mouse ear reaction for testing cell mediated immunity of human lymphocytes using the local graft-versus-host reaction assay is described. Five million human mononuclears were locally injected into the ears of immune suppressed NZW mice. The reaction mounted was quantitated by determining the 125I-Iodo-Deoxyuridine (...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(85)80050-4
更新日期:1985-02-01 00:00:00
abstract::Chromosome 1 of the mouse carries a number of genes for alloantigens which can be recognized by T cells, among those the mixed lymphocyte stimulation (Mls) locus and the lymphocyte stimulating determinant (Lsd) locus have been described. The Relationship between the antigens coded for by these two loci has been furthe...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(88)80037-8
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:An association between Tako-Tsubo cardiomyopathy (TTC) and underlying malignancies has been observed, suggesting that TTC might be the consequence of paraneoplastic phenomena. This study investigates the presence of autoantibodies against cardiomyocytes as well as adrenergic (β1, β2) and muscarinic (M2) rece...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2018.11.005
更新日期:2019-03-01 00:00:00
abstract::Recent studies have suggested that odontoblasts are involved in the dental pulp immune response to oral pathogens that invade human dentin during the caries process. How odontoblasts regulate the early inflammatory and immune pulp response to Gram-positive bacteria, which predominate in shallow and moderate dentin car...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.08.006
更新日期:2011-04-01 00:00:00
abstract::Successful reconstitution of T lymphocytes after allogeneic haematopoietic stem cell transplantation (HSCT) is needed to establish the graft-versus-leukaemia effect and an effective anti-microbial defense, but the ratio between functionally different T-cell subsets needs to be balanced to avoid graft-versus-host disea...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.10.023
更新日期:2018-02-01 00:00:00
abstract::Dogs infected with Leishmania infantum have a reduced number of T lymphocytes. PD-1 (Programmed cell death 1) a new member of the B7-CD28 family that is expressed by immune cells, and its binding to PD-L1 (CD274) or PD-L2 (CD273) induces the deactivation or apoptosis of T cells. This study aimed to evaluate the expres...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.03.007
更新日期:2016-08-01 00:00:00
abstract::Shigella spp. are known to penetrate the colonic epithelial cells causing shigellosis, which results in production of convalescent antibodies against porin, the surface exposed major outer membrane protein. Porin has been categorized as primarily TLR2-ligand and here we validated its signaling procedure in colonic INT...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2013.12.002
更新日期:2014-05-01 00:00:00
abstract::The activating C-type lectin-like receptor NKG2D, which is expressed by mouse NK cells and activated CD8 T cells, was previously demonstrated to be involved in tumor rejection and as a defense mechanism against viral and bacterial infections. Because CD8 T cells are important for protective immune responses during chr...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.09.010
更新日期:2011-05-01 00:00:00
abstract::Functional polymorphisms in RNA recognizing toll like receptors (TLR) 3, 7, 8 and toll-interleukin-1 receptor domain containing adapter protein adapter (TIRAP) coding genes were investigated in 120 dengue cases [87 dengue fever (DF) cases and 33 dengue hemorrhagic fever (DHF) cases] and 109 healthy controls (HC) to id...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.09.020
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Analysis of peripheral blood lymphocyte subsets has become an essential tool in the evaluation of outcome of diagnostic and research related questions in immunological and pathological conditions. Periodic evaluation and establishment of normal lymphocyte reference ranges are required in clinical and researc...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.02.010
更新日期:2014-07-01 00:00:00
abstract::Activated macrophages have various characteristics in common with exudate and resident macrophages, but the ability to inhibit intracellular proliferation of the protozoa Toxoplasma gondii, the expression of Ia antigen and the capacity to produce H2O2 varies among these cells. Assessment of these features of macrophag...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80575-9
更新日期:1991-12-01 00:00:00
abstract::The anticonvulsant drug phenytoin, in less than cytotoxic concentrations, caused significant reductions in Ig secretion by unstimulated or EBV-stimulated normal MNC, as measured by PFC or secretion of Ig into the culture medium. Isotype-specific LBL varied in their sensitivity, the secretion of IgA (1 line) and IgG (3...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(85)80094-2
更新日期:1985-09-01 00:00:00
abstract::IFN-γ produced during viral infections activates the IFN-γ receptor (IFNGR) complex for STAT1 transcriptional activity leading to expression of Interferon Regulatory Factors (IRF). Simultaneous activation of TBK/IKKε via TLR3 during viral infections activates the transcription factor IRF3. Together these transcription...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2019.04.004
更新日期:2019-07-01 00:00:00