Abstract：
:Attenuating the sepsis-induced systemic inflammatory response, with subsequent homeostatic imbalance, has for years been one of the main tasks in sepsis related research. Complement and the TLR family constitute two important upstream sensor and effector-systems of innate immunity. Although they act as partly independent branches of pattern recognition, recent evidence indicate a considerable cross-talk implying that they can either compensate, synergize or antagonize each other. Combined inhibition of these pathways is therefore a particularly interesting approach with a profound anti-inflammatory potential. In previous preclinical studies, we demonstrated that targeting the key molecules C3 or C5 of complement and CD14 of the TLR family had a vast anti-inflammatory effect on Gram-negative bacteria-induced inflammation and sepsis. In this review, we elucidate the significance of these key molecules as important targets for intervention in sepsis and systemic inflammatory response syndrome. Finally, we argue that a combined inhibition of complement and CD14 represent a potential general treatment regimen, beyond the limit of sepsis, including non-infectious systemic inflammation and ischemia reperfusion injury.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Barratt-Due A,Pischke SE,Brekke OL,Thorgersen EB,Nielsen EW,Espevik T,Huber-Lang M,Mollnes TEdoi
10.1016/j.imbio.2012.07.019subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1047-56issue
11eissn
0171-2985issn
1878-3279pii
S0171-2985(12)00183-0journal_volume
217pub_type
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