Abstract:
:In contrast to murine spleen M phi, resident peritoneal M phi from health mice express very little Forssman glycolipid antigen (Fo). The following experiments suggest that Fo expression by peritoneal M phi may be associated with inflammation. Balb/c and CBA/J mice were given inflammatory stimuli by i.p. injection of live BCG, thioglycollate (TG), Corynebacterium parvum (CP), proteose peptone (PP), or LPS. Control animals received pyrogen-free saline. Expression of Fo and Ia antigen by peritoneal M phi was determined by immunofluorescence after 4 d. Application of TG or CP led to an up to 30-fold increase in Fo+, Ia+ double positive M phi over that in control animals. LPS caused mainly an increase in the percentage of double-positive M phi, whereas no effects were seen in BCG or PP treated animals. To clarify the possible involvement of cytokines in this process and to identify these, the effects of LPS and various cytokines on in vitro induction of Fo and Ia expression were studied in further experiments. LPS, IL6, and IL4 caused induction of up to 15% Fo+ and Ia+ M phi after a 4 d culture period. M phi colony stimulating factor (M-CSF) from lung-conditioned medium was also moderately active. IL1, TNF, and IL2 had no influence, whereas IFN-gamma only induced Ia. For a successful in vitro induction of Fo and Ia, a prior priming of the mice with PP appeared mandatory. This suggests that only M phi of a certain developmental stage can acquire Fo under the influence of the appropriate cytokines. The data may provide the first evidence for cytokine-mediated modulation of a glycolipid antigen of known chemical structure.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
von Kleist R,Schmitt E,Westermann J,Mühlradt PFdoi
10.1016/s0171-2985(11)80302-5subject
Has Abstractpub_date
1990-06-01 00:00:00pages
405-18issue
4-5eissn
0171-2985issn
1878-3279pii
S0171-2985(11)80302-5journal_volume
180pub_type
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