Abstract：
:The supernatant from cultures of T cell clones derived from (BALB/c----C3H/He) chimeras suppresses BALB/c anti-C3H/He or BALB/c anti-C57BL/6 MLRs. When we studied the alloantigen specificity of the suppressor activity in culture supernatant, we observed three types of the suppressor activity (i.e., the suppressor activity against BALB/c anti-C3H/He MLR, against BALB/c anti-C57BL/6 MLR, and against both MLRs) on day 3 after stimulation of the T cell clones with 20% crude IL2 and feeder cells. Since the alloantigen specificity fluctuated somewhat with time, we considered that a time-course study was needed to determine it correctly. We thought it unlikely that any IFN-gamma or PGE2 in the culture supernatant of the T cell clones would have mediated the suppression. Our results suggest that alloantigen specific and non-specific suppressor T cells exist in bone marrow chimeras. The former appears to play an important role in inducing and maintaining transplantation tolerance, while the latter seems to have a rather harmful effect upon chimeras.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Imamura M,Fujimoto H,Fukuhara T,Kobayashi M,Hashino S,Kasai M,Sakurada K,Miyazaki Tdoi
10.1016/S0171-2985(88)80095-0subject
Has Abstractpub_date
1988-04-01 00:00:00pages
91-103issue
1eissn
0171-2985issn
1878-3279pii
S0171-2985(88)80095-0journal_volume
177pub_type
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