Positive association of Bx genotype, KIR2L5, KIR2DS5 and full-length KIR2DS4 with the risk of meningioma.

Abstract:

BACKGROUND:NK cells as a part of innate immune system, are controlled by a set of activating and inhibitory KIR receptors (aKIR, iKIR) which are implicated in tumor microenvironment immunity through a variety of activating and inhibitory immune signals. KIRs are multi gene family receptors that differ in the number and type of genes among individuals. In the current research we determined the KIRs genes and genotypes impact on predisposition to meningioma development in Iranians. METHODS:Sequence-specific primers-polymerase chain reaction (SSP-PCR) was performed for genotyping of 16 KIRs in 159 meningioma cases and 362 age and sex matched healthy controls (CNs) at Shiraz Institute for Cancer Research. RESULTS:Comparison of the KIR genotypes frequencies between cases and controls disclosed a highly significant increase in Bx genotype, CxTx subset and Cen AB and Tel AB in meningioma cases and a decrease in AA genotype, C4Tx subset and Cen AA, Tel AA, Tel BB in healthy controls. Among all 16 KIR genes, the carriers of KIR2DL5 and KIR2DS5 constituted a much greater proportion in meningioma than control group. Comparison of carrier frequencies of KIR2DS4 variants between case and controls revealed a higher frequency of KIR2DS4 full length (KIR2DS4fl) in meningioma cases and a lower frequency of KIR2DS4 deleted variant (KIR2DS4del) in controls. Furthermore, the simultaneous presence of 2DS5, 2DS4fl, CenAB, TelAB and absence of 2DS4del, CenAA, TelAA, TelBB, magnify the risk of developing meningioma substantially (OR ≈ 23). Altogether, 41 distinct KIR genotypes were characterized in 521 subjects. Among them, some individuals were characterized by seven peculiar genotypes that the linkage disequilibrium between KIR2DS2-KIR2DL2 and KIR2DL5-KIR2DS3-KIR2DS5 has not been detected. The carriers of certain genotypes with presence of as KIR2DL5 and absence of KIR2DS3, KIR2DS5 constituted a much higher proportion in meningioma than control group which increase the risk of meningioma up to 72 times. CONCLUSION:This case- control study suggests carriers of Bx genotype, KIR2DL5, KIR2DS5, 2DS4fl, ≥ 4 iKIR, CxTx subset as well as Cen AB and Tel AB are associated with an increased risk of developing meningioma whereas carrying KIR2DS4del, AA, C4TX genotypes and Cen AA, Tel AA, Tel BB reduce the genetic predisposition for meningioma.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Barani S,Taghipour M,Ghaderi A

doi

10.1016/j.imbio.2019.151900

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

151900

issue

2

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(19)30299-2

journal_volume

225

pub_type

杂志文章
  • Light chain heterogeneity of type lambda anti-streptococcal group A-variant polysaccharide antibodies in rabbits.

    abstract::BASILEA rabbits lack the expression of chi-polypeptide chains and compensate for this lack with expression of lambda polypeptide light chains. These rabbits were immunized with streptococcal group A-variant vaccines. The heterogeneity of the lambda polypeptide chains of specific antibodies was analyzed and compared wi...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:

    authors: Weiss S,Hild K,Braun DG

    更新日期:1979-08-01 00:00:00

  • Collagen induced arthritis (CIA) in mice features regulatory transcriptional network connecting major histocompatibility complex (MHC H2) with autoantigen genes in the thymus.

    abstract::Considering that imbalance of central tolerance in the thymus contributes to aggressive autoimmunity, we compared the expression of peripheral tissue autoantigens (PTA) genes, which are involved in self-representation in the thymic stroma, of two mouse strains; DBA-1/J (MHC-H2(q)) susceptible and DBA-2/J (MHC-H2(d)) r...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2010.09.007

    authors: Donate PB,Fornari TA,Junta CM,Magalhães DA,Macedo C,Cunha TM,Nguyen C,Cunha FQ,Passos GA

    更新日期:2011-05-01 00:00:00

  • Chemical characterization of macrophage cytotoxicity factor, macrophage migration inhibitory factor, T-helper cell-replacing factor and colony-stimulating factor from culture supernatants of concanavalin A-stimulated murine spleen cells.

    abstract::Supernatants from Concanavalin A-stimulated murine spleen cells were subjected to hydrophobic interaction chromatography on phenyl-Sepharose. Macrophage cytotoxicity factor (MCF), macrophage migration inhibitory factor (MIF), T-helper cell-replacing factor (TRF) and colony-stimulating factor (CSF) were bound at high i...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(80)80098-2

    authors: Hübner L,Kniep EM,Laukel H,Sorg C,Fischer H,Gassel WD,Havemann K,Kickhöfen B,Lohmann-Matthes ML,Schimpl A,Wecker E

    更新日期:1980-07-01 00:00:00

  • Analysis of CD16+dim and CD16+bright lymphocytes--comparison of peripheral and clonal non-MHC-restricted T cells and NK cells.

    abstract::The Fc gamma RIII receptor (CD16) has been described on natural killer cells and a small subset of T lymphocytes. CD16+bright lymphocytes represent the typical population of peripheral blood CD3- NK cells. In these studies in addition to CD16+bright NK cells Fc gamma RIII expressing cytotoxic T lymphocytes in peripher...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(11)80315-3

    authors: Uciechowski P,Werfel T,Leo R,Gessner JE,Schubert J,Schmidt RE

    更新日期:1992-06-01 00:00:00

  • Emerging pathways of non-genomic glucocorticoid (GC) signalling in T cells.

    abstract::In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating e...

    journal_title:Immunobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.imbio.2009.10.003

    authors: Boldizsar F,Talaber G,Szabo M,Bartis D,Palinkas L,Nemeth P,Berki T

    更新日期:2010-07-01 00:00:00

  • Anti-CD26 monoclonal antibodies can reversibly arrest human T lymphocytes in the late G1 phase of the cell cycle.

    abstract::Three different anti-CD26 monoclonal antibodies (mAbs) are described, which specifically inhibited proliferation of human T lymphocytes after stimulation with PHA, tetanus toxoid or soluble anti-CD3 mAb. Anti-CD26 mAbs induced in T cells a dose-dependent shift of the maximum of DNA synthesis, which was due to a transi...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(11)80485-7

    authors: Mattern T,Ansorge S,Flad HD,Ulmer AJ

    更新日期:1993-06-01 00:00:00

  • Comparative analysis of the internalization of the macrophage receptor sialoadhesin in human and mouse primary macrophages and cell lines.

    abstract::Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2016.11.013

    authors: De Schryver M,Leemans A,Pintelon I,Cappoen D,Maes L,Caljon G,Cos P,Delputte PL

    更新日期:2017-06-01 00:00:00

  • Epigenetic mechanisms of macrophage activation in type 2 diabetes.

    abstract::The alarming rise of obesity and type 2 diabetes (T2D) has put a tremendous strain on global healthcare systems. Over the past decade extensive research has focused on the role of macrophages as key mediators of inflammation in T2D. The inflammatory environment in the obese adipose tissue and pancreatic β-cell islets ...

    journal_title:Immunobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.imbio.2016.08.011

    authors: Ahmed M,de Winther MPJ,Van den Bossche J

    更新日期:2017-10-01 00:00:00

  • Cytokine production of the human monocytic cell line Mono Mac 6 in comparison to mature monocytes in peripheral blood mononuclear cells.

    abstract::Mono Mac 6 is a human monocytic cell line with several features of mature blood monocytes such as CD 14 antigen expression, phagocytotic ability, and the functional ability to produce cytokines. This line is often used as an in vitro model to demonstrate the actions of monocytes. In our study, the production of cytoki...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(11)80237-8

    authors: Neustock P,Brand JM,Kruse A,Kirchner H

    更新日期:1993-07-01 00:00:00

  • Decreased density in membrane localized macromolecules in cells enlarged after X-irradiation or polyploidization.

    abstract::Cytophotometric measurements of DNA, dry mass (total proteins) and surface localized IgM and Ia were performed on individual cells of a Burkitt lymphoma derived cell line after X-irradiation and after polyploidization. Blockage of cell division was achieved with 250 r, and an arrest in G2 was found 48 hr after irradia...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(80)80099-4

    authors: Killander D,Klein E,Shapiro I,Lundin L

    更新日期:1980-07-01 00:00:00

  • Multidirectional interactions in vitro between lymphoid cells from Mls-disparate strains.

    abstract::Chromosome 1 of the mouse carries a number of genes for alloantigens which can be recognized by T cells, among those the mixed lymphocyte stimulation (Mls) locus and the lymphocyte stimulating determinant (Lsd) locus have been described. The Relationship between the antigens coded for by these two loci has been furthe...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(88)80037-8

    authors: Goldbach J,Prahl H,Stäb F,Steinhausen D,Kölsch E

    更新日期:1988-05-01 00:00:00

  • MHC- and Igh-unrestricted interaction between L3T4+, Lyt-2- Ts inducer cells and L3T4-, Lyt-2+ Ts effector cells is required for T cell-dependent suppression of DTH to histocompatibility antigens.

    abstract::This paper describes the characteristics of T suppressor inducer (Ts ind) cells which can interact with T suppressor effector (Ts eff) cells and thereby can account for suppression of delayed-type hypersensitivity (DTH) to alloantigens. Adoptive transfer of spleen cells from mice intravenously (i.v.) injected with all...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/s0171-2985(89)80007-5

    authors: Molendijk A,van Gurp RJ,Knulst AC,Benner R

    更新日期:1989-03-01 00:00:00

  • Vitamin D reduces the differentiation and expansion of Th17 cells in young asthmatic children.

    abstract::Vitamin D [25(OH)D3] deficiency has been associated with asthma as in many inflammatory and autoimmune pathologies; however, there is still a lack of data about the effects of administration of vitamin D in immune regulation in young asthmatic patients. In this study, we investigated its inhibitory effect on the immun...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2014.07.009

    authors: Hamzaoui A,Berraïes A,Hamdi B,Kaabachi W,Ammar J,Hamzaoui K

    更新日期:2014-11-01 00:00:00

  • Properties of soluble CR2 in human serum.

    abstract::A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3d...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(11)80656-X

    authors: Ling NR,Brown B

    更新日期:1992-08-01 00:00:00

  • Age-related changes of mitogen responsiveness in different lymphoid organs from outbred NMRI mice.

    abstract::Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(81)80014-9

    authors: Joncourt F,Bettens F,Kristensen F,de Weck AL

    更新日期:1981-06-01 00:00:00

  • Regulation of expression of the LFA-1 and p150,95 leukocyte integrins: involvement of the CD11a and CD11c gene promoters.

    abstract::Human Lymphocyte Associated Antigen-1 (LFA-1, CD11a/CD18, alpha L/beta 2) and p150,95 (CD11c/CD18, alpha X/beta 2) are cell surface alpha/beta heterodimers that, together with Mac-1 (CD11b/CD18, alpha M/beta 2) comprise the leukocyte-restricted beta 2 subfamily of integrins. LFA-1 is the only integrin expressed on all...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/s0171-2985(11)80560-7

    authors: López-Rodríguez C,Nueda A,Rubio M,Corbí AL

    更新日期:1995-07-01 00:00:00

  • The CD300 molecules regulate monocyte and dendritic cell functions.

    abstract::The CD300 glycoproteins are a family of related leucocyte surface molecules that modulate a diverse array of cell processes via their paired triggering and inhibitory receptor functions. All family members have a single Ig-V like domain and they share a common evolutionary pathway. At least one member of the family ha...

    journal_title:Immunobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.imbio.2009.06.004

    authors: Clark GJ,Ju X,Azlan M,Tate C,Ding Y,Hart DN

    更新日期:2009-01-01 00:00:00

  • Circulating complexes of the vitamin D binding protein with G-actin induce lung inflammation by targeting endothelial cells.

    abstract::This study investigated the actin scavenger function of the vitamin D binding protein (DBP) in vivo using DBP null (-/-) mice. Intravenous injection of G-actin into wild-type (DBP+/+) and DBP-/- mice showed that contrary to expectations, DBP+/+ mice developed more severe acute lung inflammation. Inflammation was restr...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2013.10.001

    authors: Ge L,Trujillo G,Miller EJ,Kew RR

    更新日期:2014-03-01 00:00:00

  • Effect of L-alanine and some other amino acids on thymocyte proliferation in vivo.

    abstract::L-alanine was shown earlier to play a significant role for the proliferation of lymphocytes in vitro. In the present work the effect of L-alanine and some other amino acids on thymocyte proliferation was studied in vivo by local administration into one thymus lobe of guinea pigs. Proliferating cells were pulse labelle...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(11)80487-0

    authors: Hägglund B,Sandberg G

    更新日期:1993-06-01 00:00:00

  • Lung function and inflammation during murine Pseudomonas aeruginosa airway infection.

    abstract:BACKGROUND:Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs. OBJECTIVES:The present study investigates the association between immune response and decline in lung function...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2011.02.003

    authors: Wölbeling F,Munder A,Kerber-Momot T,Neumann D,Hennig C,Hansen G,Tümmler B,Baumann U

    更新日期:2011-08-01 00:00:00

  • Differential effector functions of central and peripheral compartments of immune response system: characterization of immune responses in the spleen and mesenteric lymph nodes to directly injected sheep red blood cells.

    abstract::When sheep red blood cells (SRBC) were injected intraperitoneally (i.p.), intravenously (i.v.), or into the Peyer's patches, definite plaque-forming cell (PFC) and rosette-forming cell (RFC) responses were induced in the spleen but not in the mesenteric lymph nodes (MLN). When SRBC were injected directly into the sple...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/s0171-2985(82)80047-8

    authors: Kojima T,Kamei H,Kondo T,Nakashima I,Kato N

    更新日期:1982-05-01 00:00:00

  • Identifying patients with neutrophil elastase (ELANE) mutations from patients with a presumptive diagnosis of autoimmune neutropenia.

    abstract::To differentiate severe congenital neutropenia (SCN) from autoimmune neutropenia (AIN) in patients with persistent neutropenia ≤1000/mm(3) over three months, we evaluated anti-neutrophil auto-antibodies, candidate genes of ELANA, HAX1 and GCSFR, and neutrophil elastase (NE) activity in 38 patients (21 females; average...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2012.09.001

    authors: Lee WI,Chen SH,Huang JL,Jaing TH,Chung HT,Yeh KW,Chen LC,Yao TC,Hsieh MY,Lin SJ,Kuo ML

    更新日期:2013-05-01 00:00:00

  • "Self-reactive" T cells. III. In vitro restimulation of T cells, "responding" in vivo or in vitro to syngeneic lymphoid cells.

    abstract::Polyclonally activated lymphoblasts, transferred to syngeneic recipient mice, elicited a host T-cell-mediated "response" in vivo. These T cells, which "responded" in vivo to syngeneic lymphoblasts (i.e. in vivo primed "responder" T-cell population), acquired the capacity to "stimulate" a "response" of syngeneic T cell...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(80)80015-5

    authors: Reimann J,Diamantstein T

    更新日期:1980-12-01 00:00:00

  • Functional analysis of mouse ficolin-B and detection in neutrophils.

    abstract::Ficolins and mannan-binding lectin recognize pathogen-associated molecular patterns and initiate the lectin pathway of complement activation via the associated serine proteases. In contrast to human ficolins and mouse ficolin-A, mouse ficolin-B has been considered incapable of complement activation. Dose-dependent bin...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2012.01.013

    authors: Hunold K,Weber-Steffens D,Runza VL,Jensenius JC,Männel DN

    更新日期:2012-10-01 00:00:00

  • Effect of fetal calf serum on cytokine release by bone marrow-derived macrophages during infection with intracellular bacteria.

    abstract::Bone marrow-derived macrophages (BMM) comprise a population of quiescent cells which can be activated by defined signals. Here, we directly compare the release of chemokines and monokines by BMM raised either in serum-supplemented or in serum-free medium in response to Listeria monocytogenes EGD or Mycobacterium bovis...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(99)80037-0

    authors: Flesch IE,Kaufmann SH

    更新日期:1999-02-01 00:00:00

  • RNA interference mediated silencing of Hsp60 gene in human monocytic myeloma cell line U937 revealed decreased dengue virus multiplication.

    abstract::Heat shock proteins (Hsps) or stress proteins are highly conserved molecules and expressed in all cell types under stressful conditions like heat, cold, hypoxia and infections. The objective of the present study was to determine the effect of dengue virus infection on relative expression of stress proteins and their r...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2008.11.010

    authors: Padwad YS,Mishra KP,Jain M,Chanda S,Karan D,Ganju L

    更新日期:2009-01-01 00:00:00

  • Lidocaine inhibits epithelial chemokine secretion via inhibition of nuclear factor kappa B activation.

    abstract:AIM:To study the antiinflammatory effect of lidocaine in intestinal epithelial cells. METHODS:HT-29 and T-84 cells were grown in culture with and without TNF-alpha, lidocaine, aconitine and veratridine. The secretion of IL-8 and IP-10 was measured by ELISA. A cDNA microarray was used to assess gene expression. Real-ti...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2009.05.006

    authors: Lang A,Ben Horin S,Picard O,Fudim E,Amariglio N,Chowers Y

    更新日期:2010-04-01 00:00:00

  • A mouse ear reaction for assessment of human lymphocyte immunocompetence.

    abstract::A mouse ear reaction for testing cell mediated immunity of human lymphocytes using the local graft-versus-host reaction assay is described. Five million human mononuclears were locally injected into the ears of immune suppressed NZW mice. The reaction mounted was quantitated by determining the 125I-Iodo-Deoxyuridine (...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(85)80050-4

    authors: Mukamel E,Umiel T,Shohat B,Pecht M,Servadio C,Trainin N

    更新日期:1985-02-01 00:00:00

  • Insights into the immunogenetic basis of two ganglioside-associated idiotypic networks.

    abstract::The heavy-chain variable regions (VH) from 14F7 MAb, an IgG1 antibody specific for GM3(NeuGc) ganglioside, and its anti-idiotype, the 4G9 MAb, were cloned and sequenced. Comparison with previously reported sequences showed that VH 14F7 belongs to the J558(VHI) gene family and that it is highly mutated. VH 4G9 belongs ...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/j.imbio.2006.08.005

    authors: Rodríguez M,Roque-Navarro L,López-Requena A,Moreno E,Mateo de Acosta C,Pérez R,María Vázquez A

    更新日期:2007-01-01 00:00:00

  • Expression of transcription factor genes after influenza A virus infection.

    abstract::Infection of human monocytes with influenza A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis. The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorl...

    journal_title:Immunobiology

    pub_type: 杂志文章

    doi:10.1016/S0171-2985(97)80049-6

    authors: Bussfeld D,Bacher M,Moritz A,Gemsa D,Sprenger H

    更新日期:1997-12-01 00:00:00