P53 supports endothelial barrier function via APE1/Ref1 suppression.

Abstract:

:The tumor suppressor protein P53 is strongly involved in orchestrating cellular defenses in the diverse variety of human tissues. Anomalies to lung endothelium permeability are streaming severe consequences towards human health, often associated with fatal outcomes. Ongoing investigations suggest that P53 exerts a prominent strategic role in crucial signaling cascades, in charge of both the maintenance and defense of pulmonary endothelium against toxic intruders. The current study employs human and bovine lung microvascular cells, as well as pharmacologic and genetic P53 modulators to demonstrate the negative regulation of APE1/Ref1 by P53. Moreover, it includes real time measurements of endothelial permeability, to reveal the disruptive role of APE1/Ref1 towards endothelial integrity. Those findings supports our efforts to elucidate the highly sophisticated regulatory network that enact endothelial adaptations under the plethora of challenging environmental factors.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Uddin MA,Akhter MS,Siejka A,Catravas JD,Barabutis N

doi

10.1016/j.imbio.2019.04.008

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

532-538

issue

4

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(19)30117-2

journal_volume

224

pub_type

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