Abstract:
:The tumor suppressor protein P53 is strongly involved in orchestrating cellular defenses in the diverse variety of human tissues. Anomalies to lung endothelium permeability are streaming severe consequences towards human health, often associated with fatal outcomes. Ongoing investigations suggest that P53 exerts a prominent strategic role in crucial signaling cascades, in charge of both the maintenance and defense of pulmonary endothelium against toxic intruders. The current study employs human and bovine lung microvascular cells, as well as pharmacologic and genetic P53 modulators to demonstrate the negative regulation of APE1/Ref1 by P53. Moreover, it includes real time measurements of endothelial permeability, to reveal the disruptive role of APE1/Ref1 towards endothelial integrity. Those findings supports our efforts to elucidate the highly sophisticated regulatory network that enact endothelial adaptations under the plethora of challenging environmental factors.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Uddin MA,Akhter MS,Siejka A,Catravas JD,Barabutis Ndoi
10.1016/j.imbio.2019.04.008subject
Has Abstractpub_date
2019-07-01 00:00:00pages
532-538issue
4eissn
0171-2985issn
1878-3279pii
S0171-2985(19)30117-2journal_volume
224pub_type
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