Abstract:
:Intravenous (i.v.) immunization of mice with irradiated (2000 rads) allogeneic lymphoid cells induces the generation of suppressor T cells. Such suppressor T cells can suppress the anti-host delayed type hypersensitivity (DTH) by other T cells during acute Graft-versus-Host reactions in irradiated recipient mice. Suppression of anti-host DTH is detectable at least 50 days after i.v. induction of the state of suppression in the donors. The generation of suppressor T cells in the donors is associated with proliferation. Furthermore, the suppressor T cells need to proliferate further in the irradiated allogeneic hosts in order to display a maximal suppressive effect. Two types of suppressor T cells were found to be required for suppression of the anti-host DTH response: a Lyt-1+2- cell population and a Lyt-1-2+ cell population.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Bril H,Molendijk-Lok BD,Hussaarts-Odijk LM,Benner Rdoi
10.1016/S0171-2985(85)80035-8subject
Has Abstractpub_date
1985-04-01 00:00:00pages
213-27issue
3eissn
0171-2985issn
1878-3279pii
S0171-2985(85)80035-8journal_volume
169pub_type
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