Abstract:
:Using irradiation bone marrow chimeras to analyze restriction specificity of helper T cells, we found that recipient H-2 type dictated the H-2 type which the T cells recognize as self (adaptive differentiation). T cells from (H-2b----H-2k) chimeras cooperate with non-T cells bearing Iak to generate a vigorous PFC response to sheep erythrocytes (SRBC) in vitro, but not with genetically identical H-2b cells. However, when T cells from the chimeras and H-2b non-T cells were adoptively transferred into irradiated (donor X recipient) F1 mice with SRBC, marked responses were seen in recipient spleens where radio-resistant F1 macrophages might exist and act as antigen presenting cells (APC). From these in vitro and in vivo observations, we considered that in the primary antibody response to a T dependent antigen such as SRBC, only T cell-macrophage (APC) matching is required. In contrast, when T cells from H-2 incompatible chimeras which had been primed with SRBC in vivo were analyzed in vitro, these cells cooperated also with H-2b non-T cells. These findings indicate that there may be two separate stages of T cell differentiation during which the self restriction specificity is acquired: one appears to be responsive to intrathymic influences and is not associated with antigenic stimuli, and the other shows signs of being responsive to post-thymic stimuli and of involving antigenic presentation. Moreover, the latter appears to utilize the influence of donor type macrophages.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Onoé K,Yasumizu R,Noguchi M,Iwabuchi K,Ogasawara M,Kakinuma M,Okuyama H,Good RA,Morikawa Kdoi
10.1016/S0171-2985(85)80054-1subject
Has Abstractpub_date
1985-02-01 00:00:00pages
60-70issue
1eissn
0171-2985issn
1878-3279pii
S0171-2985(85)80054-1journal_volume
169pub_type
杂志文章相关文献
IMMUNOBIOLOGY文献大全abstract::The aim of this study was to evaluate some immunological patterns involved in natural and acquired resistance against MHV3 using the original model of genetically modified lines of mice selected for high (HIII) and low (LIII) antibody responsiveness. As previously shown, a lower pre-existing anti-MHV antibody level wa...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1078/0171-2985-00239
更新日期:2003-01-01 00:00:00
abstract::Functional polymorphisms in RNA recognizing toll like receptors (TLR) 3, 7, 8 and toll-interleukin-1 receptor domain containing adapter protein adapter (TIRAP) coding genes were investigated in 120 dengue cases [87 dengue fever (DF) cases and 33 dengue hemorrhagic fever (DHF) cases] and 109 healthy controls (HC) to id...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.09.020
更新日期:2015-01-01 00:00:00
abstract::The inability of spontaneous and some laboratory-induced tumors to stimulate the immune system has continuously raised the question of the validity of using immunological maneuvers in order to control tumor growth. In this project we suggest that a tumor which is nonimmunogenic still has an immunogenic potential that ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(82)80101-0
更新日期:1982-10-01 00:00:00
abstract::Neutrophils, the most abundant leukocyte in human circulation are being more and more recognized as part of the immune reaction to cancer. In the last years, the understanding that neutrophils possess a dual role in cancer development has emerged. During tumor progression the number of neutrophils increase, and their ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2016.02.001
更新日期:2017-01-01 00:00:00
abstract::C1r, the enzyme responsible for intrinsic activation of the C1 complex of complement, is a modular serine protease featuring an overall structural organization homologous to those of C1s and the mannan-binding lectin-associated serine proteases (MASPs). This review will initially summarize current information on the s...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1078/0171-2985-00139
更新日期:2002-09-01 00:00:00
abstract::An ELISA with covalently fixed antigens was used to measure and define ferritin-labeled antibodies. In the presented model, RIG covalently fixed to glass tubes served as antigen. Twenty ferritin-labeled SWaRIG conjugates were prepared with different molar ratios of antibody: ferritin: glutaraldehyde. At various diluti...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(84)80021-2
更新日期:1984-05-01 00:00:00
abstract::Previous studies have demonstrated that methamphetamine (METH) alter inflammatory and anti-inflammatory cytokine production in the periphery. However, the effect of METH on lipopolysaccharide (LPS)-induced immune responses and its underlying mechanism of action remains unclear. The dopamine D3 receptor (D3R) plays an ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.12.021
更新日期:2015-06-01 00:00:00
abstract::Based on the similar effects that HIV-1 gp41 like human type I interferons (IFN-alpha and -beta) upregulated MHC expression and inhibited lymphocyte proliferation, we compared amino acid sequences of gp41 and human type I interferons (IFN-alpha and -beta), and found sequence-similarity existing between the immunosuppr...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(98)80043-0
更新日期:1998-02-01 00:00:00
abstract:INTRODUCTION:Fexofenadine (FXF) is a third-generation antihistamine drug and osthole is assumed as a natural antihistamine alternative. This paper compares results of histamine, FXF and osthole impact on HRH-1, COX-2, NF-κB-p50, CCR1 mRNA expression. We also measured mRNA expression of IL-1β and CCL5/RANTES in incubate...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.11.004
更新日期:2017-03-01 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells capable of abrogating T and B cells responses and have been identified in numerous cancers. As with other regulatory cell populations, they aim to maintain balance between host-defence-associated inflammation and ensuing tissue pathology. MDSC accumulati...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2017.07.001
更新日期:2018-01-01 00:00:00
abstract::The concept of using mesenchymal stem cells (MSCs) in bone repair has progressively evolved, and the goal of cell-mediated therapy is to prolong the natural physiological abilities of healing, or substitute them, when these are lacking, failing, or progressing too slowly. The future application of MSCs in human therap...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2008.07.030
更新日期:2009-01-01 00:00:00
abstract::Prior work demonstrated that a splice variant of SCN5A, a voltage-gated sodium channel gene, acts as a cytoplasmic sensor for viral dsRNA in human macrophages. Expression of this channel also polarizes macrophages to an anti-inflammatory phenotype in vitro and in vivo. Here we utilized global expression analysis of sp...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2018.10.005
更新日期:2019-01-01 00:00:00
abstract::The CD83 molecule (CD83) is a well-known surface marker present on mature dendritic cells (mDC). In this study, we show that CD83 is also expressed on a subset of T cells which mediate regulatory T cell (Treg)-like suppressor functions in vitro and in vivo. Treg-associated molecules including CD25, cytotoxic T lymphoc...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.08.005
更新日期:2015-02-01 00:00:00
abstract::LIF activity production by ConA-stimulated mononuclear cells was tested by measuring granulocyte migration from clotted plasma droplets placed in Microtest II plates. 90 min. incubation of MNC cultures with ConA assured a significant LIF activity in the 24 h. culture supernatants. Removal of the adherent cells after C...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(81)80097-6
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Ficolins serve as soluble recognition molecules in the lectin pathway of complement. They are known to participate in the systemic host-response to infection but their role in local pulmonary defence is still incompletely understood. The purpose of this study was to clarify whether acute lung and systemic in...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.11.015
更新日期:2016-05-01 00:00:00
abstract::Culture supernatants (CS) from Hodgkin derived cell lines have previously been shown to contain colony stimulating activity (CSF) for human cord blood cells, fetal bone marrow and fetal liver cells. In this study 3-day CS from four Hodgkin lines (L428, L538, L540, L591) and two sublines (L428KS, L428KSA) were examined...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(84)80049-2
更新日期:1984-05-01 00:00:00
abstract::The interaction between the T cell receptor (TCR) and the peptide-MHC complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC) is the main event controlling the specificity of antigen recognition by T cells. It is thought that TCR/pMHC binding kinetics are critical for the selection of ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2005.09.003
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:T helper cells can differentiate into several subsets of T lymphocytes, including Th1, Th2, and regulatory T (Treg) cells. As a result of this ability to differentiate, the corresponding T cell receptor (TCR) spectra display considerable cellular plasticity and interchangeability. In contrast, T lymphocyte d...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.02.007
更新日期:2017-07-01 00:00:00
abstract::Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2016.07.009
更新日期:2016-12-01 00:00:00
abstract::The immunoglobulin production capacities of peripheral blood lymphocytes obtained from patients with various chronic inflammatory liver diseases and from normal individuals were compared. Using a reverse hemolytic plaque assay, immunoglobulin-secreting cells (ISC) were counted immediately after isolation (immediate IS...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(88)80066-4
更新日期:1988-12-01 00:00:00
abstract::The polymorphonuclear neutrophil (PMN) regulates in vivo and in vitro immune responses. We report that the immunoenhancing properties of PMN culture supernatants from PMN recruited by the bacterium Actinomyces viscosus (AV) show its exclusive effects on the T cell lymphocyte population. A study of the effect of PMN su...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(83)80066-7
更新日期:1983-12-01 00:00:00
abstract::The T effector lymphocytes of delayed type hypersensitivity reactions (TDH) are regulated by a complex T suppressor (Ts) cell circuit. Induction of TDH cells requires Ia+ adherent cells as antigen-presenting cells. Little is known about the antigen presentation of the induction of Ts cells. We describe an experimental...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(84)80114-X
更新日期:1984-12-01 00:00:00
abstract::It is well known that adherence of monocytes (MO) to extracellular matrix substrates or tissue culture plastic activates these cells and induces the expression of a multitude of genes. Especially, it was described, that MO are primed by cell adhesion to produce higher amounts of some cytokines, e.g. interleukin (IL)-8...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(97)80069-1
更新日期:1996-01-01 00:00:00
abstract::We investigated the mRNA expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in human T cell lymphotropic virus type I (HTLV-I) p40tax-transfected U937 cells, a human monoblast cell line. Transfection of HTLV-I p40tax U937 cells induced up-regulation of iNOS mRNA expression and...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(97)80083-6
更新日期:1997-11-01 00:00:00
abstract::Surfactant protein D has multiple functions in innate immunity in the lung. The generation of SP-D knock-out mice has revealed a central role for this protein in the control of lung inflammation. Accumulating evidence in mouse models of infection and inflammation indicates that truncated recombinant forms of surfactan...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1078/0171-2985-00159
更新日期:2002-09-01 00:00:00
abstract::Most malignant tumors contain so-called tumor-associated macrophages (TAM) as a major component of their leukocytic infiltrate. To investigate the impact of the tumor microenvironment on activation and differentiation of macrophages, we established a 3-dimensional model system by culturing human monocytes within multi...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1078/0171-2985-00246
更新日期:2003-01-01 00:00:00
abstract::In bitches, the onset of pyometra, an infection of the uterus, characteristically occurs in the first half of the diestrous stage in the estrous cycle, in which the blood concentration of progesterone peaks and that of estradiol-17beta is lowest. To investigate the immunological mechanisms governing stage-specific ons...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2004.09.003
更新日期:2004-01-01 00:00:00
abstract::We examined the expression of seven V alpha or V beta T cell receptor (TCR) segments on human CD4+ and CD8+ T cells. Confirming previously published results, we found a preferential expression of four V segment gene products on CD4+ T cells. One of these markers (V beta 6.7) was constantly expressed on more CD4+ T cel...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(11)80242-1
更新日期:1993-01-01 00:00:00
abstract::The octamer motif is a crucial regulatory element for immunoglobulin promoter and enhancer function. We have investigated the molecular mechanisms that underlie octamer-mediated gene activation in B cells. This B cell-specific transcriptional regulation is subject to a novel type of regulatory mechanism. We could demo...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(11)80540-1
更新日期:1995-07-01 00:00:00
abstract::Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the TLRs are of considerable interest. Here we seek to determine the molecular mechanism by ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2019.12.004
更新日期:2020-03-01 00:00:00