Differential expression of T cell receptor variable beta genes on CD4+ and CD8+ T cells: influence by sex linked genes?

abstract：:A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3d...

journal_title：Immunobiology

authors： Ling NR,Brown B

更新日期：1992-08-01 00:00:00

abstract：:The phenotype frequency of the platelet-specific antigens P1A1/A2 ( = Zw(a,b)) in the German population (N = 711) is 97.75% and 2.25% respectively. The corresponding gene frequencies are P1A1 0.85; P1A2 0.15. The P1A1 determinant is codominantly inherited (19 families; 151 family members). There is a strong gene dosag...

journal_title：Immunobiology

authors： Mueller-Eckhardt C,Marks HJ,Baur MP,Mueller-Eckhardt G

更新日期：1982-02-01 00:00:00

abstract：:Erythrocytes from paroxysmal nocturnal hemoglobinuria patients (PNH-E) are much more susceptible to lysis by acid-activated human serum than normal human erythrocytes. Acidification of normal human serum to pH 6.4 in the absence of erythrocytes generates this lytic activity independently of the alternative pathway of ...

journal_title：Immunobiology

authors： Hänsch G,Hammer C,Jiji R,Rother U,Shin M

更新日期：1983-03-01 00:00:00

abstract：:The recent purification and cloning of T cell-derived growth factors, should lead to rapid progress in delineating their role in the generation of accessory cells and the regulation of their function. The techniques that have allowed detailed in vitro studies of the T-dependent mast cells, should be generally applicab...

journal_title：Immunobiology

authors： Schrader JW,Clark-Lewis I,Wong GH

更新日期：1984-12-01 00:00:00

abstract：:The Fc gamma RIII receptor (CD16) has been described on natural killer cells and a small subset of T lymphocytes. CD16+bright lymphocytes represent the typical population of peripheral blood CD3- NK cells. In these studies in addition to CD16+bright NK cells Fc gamma RIII expressing cytotoxic T lymphocytes in peripher...

journal_title：Immunobiology

authors： Uciechowski P,Werfel T,Leo R,Gessner JE,Schubert J,Schmidt RE

更新日期：1992-06-01 00:00:00

abstract：:The defective antigen presenting ability of antigen presenting cells (APCs) modulates host cytokines and co-stimulatory signals that may lead to severity of leprosy. In the present study, we sought to evaluate the phenotypic features of APCs along with whether DC SIGN (DC-specific intercellular adhesion molecule-grabb...

journal_title：Immunobiology

authors： Kumar S,Naqvi RA,Bhat AA,Rani R,Ali R,Agnihotri A,Khanna N,Rao DN

更新日期：2013-12-01 00:00:00

abstract：:The Hepatitis B virus (HBV) e antigen (HBeAg) is a secretory, non-structural protein, and associated with persistent infection of HBV. Previous studies indicate that HBeAg is able to regulate T cell-mediated responses, however, the interaction between HBeAg and the innate immune system is poorly understood. In this st...

journal_title：Immunobiology

authors： Leu CM,Lu YC,Peng WL,Chu HT,Hu CP

更新日期：2014-11-01 00:00:00

abstract：:The specificity of cytotoxic T lymphocyte (CTL) responses generated in the presence of lymphokines was studied. Thymic responder cells were activated in the presence of stimulator cells that differed in their metabolic activity. After 5 days of culture, the cytotoxic response was estimated in a 4-h 51Cr-release test. ...

journal_title：Immunobiology

authors： Männel DN,Dröge W,Falk W

更新日期：1985-09-01 00:00:00

abstract：:Human Lymphocyte Associated Antigen-1 (LFA-1, CD11a/CD18, alpha L/beta 2) and p150,95 (CD11c/CD18, alpha X/beta 2) are cell surface alpha/beta heterodimers that, together with Mac-1 (CD11b/CD18, alpha M/beta 2) comprise the leukocyte-restricted beta 2 subfamily of integrins. LFA-1 is the only integrin expressed on all...

journal_title：Immunobiology

authors： López-Rodríguez C,Nueda A,Rubio M,Corbí AL

更新日期：1995-07-01 00:00:00

abstract：:The CD300 glycoproteins are a family of related leucocyte surface molecules that modulate a diverse array of cell processes via their paired triggering and inhibitory receptor functions. All family members have a single Ig-V like domain and they share a common evolutionary pathway. At least one member of the family ha...

journal_title：Immunobiology

authors： Clark GJ,Ju X,Azlan M,Tate C,Ding Y,Hart DN

更新日期：2009-01-01 00:00:00

abstract：:The Early Growth Response Genes (EGR-1 to AT133/EGR-4) encode a family of proteins that are composed of three homologous consecutive zinc fingers of the Cys2-His2 type and different flanking sequence. Upon growth stimulation of resting cells the four EGR-genes are simultaneously transcribed. We have analyzed the expre...

journal_title：Immunobiology

authors： Skerka C,Decker EL,Zipfel PF

更新日期：1997-12-01 00:00:00

abstract：:L-alanine was shown earlier to play a significant role for the proliferation of lymphocytes in vitro. In the present work the effect of L-alanine and some other amino acids on thymocyte proliferation was studied in vivo by local administration into one thymus lobe of guinea pigs. Proliferating cells were pulse labelle...

journal_title：Immunobiology

authors： Hägglund B,Sandberg G

更新日期：1993-06-01 00:00:00

abstract：:People deficient in C1-INH present recurrent angioedema localized to subcutaneous or mucous tissues. The defect can be caused by impaired synthesis, due to a genetic defect (hereditary angioedema), or by increased catabolism (acquired angioedema). In our experience the majority of patients with acquired angioedema (16...

journal_title：Immunobiology

authors： Cicardi M,Bergamaschini L,Cugno M,Beretta A,Zingale LC,Colombo M,Agostoni A

更新日期：1998-08-01 00:00:00

abstract：:The heavy-chain variable regions (VH) from 14F7 MAb, an IgG1 antibody specific for GM3(NeuGc) ganglioside, and its anti-idiotype, the 4G9 MAb, were cloned and sequenced. Comparison with previously reported sequences showed that VH 14F7 belongs to the J558(VHI) gene family and that it is highly mutated. VH 4G9 belongs ...

journal_title：Immunobiology

authors： Rodríguez M,Roque-Navarro L,López-Requena A,Moreno E,Mateo de Acosta C,Pérez R,María Vázquez A

更新日期：2007-01-01 00:00:00

abstract：:The lymphotoxin beta receptor (LTbetaR) mediates crucial signals in host defense against intracellular bacteria and viruses. Mice deficient in LTbetaR readily succumb to infections with Listeria monocytogenes, Mycobacterium tuberculosis and murine cytomegalovirus (mCMV). LTbetaR has been shown to be important for the ...

journal_title：Immunobiology

authors： Kutsch S,Degrandi D,Pfeffer K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Following any acute irritation lung function declines rapidly. Reasons for pulmonary deterioration in humans had been attributed to the action of either interleukin-6 or interleukin-8 in the lungs. OBJECTIVES:The present study investigates the association between immune response and decline in lung function...

journal_title：Immunobiology

authors： Wölbeling F,Munder A,Kerber-Momot T,Neumann D,Hennig C,Hansen G,Tümmler B,Baumann U

更新日期：2011-08-01 00:00:00

abstract：:A heterogeneous set of cells that are commonly grouped as "myeloid cells", interacts in a complex landscape of physiological and pathological situations. In this review we attempt to trace a profile of the "myeloid connection" through different normal and pathological states, by analyzing common metabolic pathways of ...

journal_title：Immunobiology

authors： Peranzoni E,Marigo I,Dolcetti L,Ugel S,Sonda N,Taschin E,Mantelli B,Bronte V,Zanovello P

更新日期：2007-01-01 00:00:00

abstract：:In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to S...

journal_title：Immunobiology

authors： Trück J,Lazarus R,Clutterbuck EA,Bowman J,Kibwana E,Bateman EA,Pollard AJ

更新日期：2013-03-01 00:00:00

abstract：:A glycoprotein from human erythrocyte membranes has been found to inhibit lysis of target cells by the attack-phase components C5-C9 from human complement. The inhibiting molecule was purified and identified as glycophorin A. Thus, glycophorin A may have a regulatory function in the lytic complement attack on isologou...

journal_title：Immunobiology

authors： Brauch H,Roelcke D,Rother U

更新日期：1983-08-01 00:00:00

abstract：:OK-432, a streptococcal preparation, has been shown as an effective activator to induce human monocyte-derived dendritic cells maturation. During this process, the activation of Toll-like receptor 4 plays an important role. However, the signaling pathway involved in has not been fully understood. In the present study,...

journal_title：Immunobiology

authors： Pan K,Wang H,Liu WL,Zhang HK,Zhou J,Li JJ,Weng DS,Huang W,Sun JC,Liang XT,Xia JC

更新日期：2009-01-01 00:00:00

abstract：:CD147 is a broadly expressed cell surface molecule of the immunoglobulin superfamily whose expression is up-regulated upon T cell activation. Engagement of CD147 by CD147 monoclonal antibodies (mAbs) has been shown to induce homotypic aggregation of U937 cells. To study intracellular signal transduction induced by the...

journal_title：Immunobiology

authors： Khunkeawla P,Moonsom S,Staffler G,Kongtawelert P,Kasinrerk W

更新日期：2001-05-01 00:00:00

abstract：:The majority of B lymphocytes, virgin T lymphocytes and a subpopulation of memory T cells express the addressin, L-selectin. Natural killer (NK) cells in rodents and humans also express L-selectin. We have shown that a similar proportion (40%) of NK cells in mouse spleen also express the integrin, CD18Mac-1, and moreo...

journal_title：Immunobiology

authors： Lejtenyi D,Osmond DG,Miller SC

更新日期：2003-01-01 00:00:00

abstract：:In a subgroup of CVID T cell abnormalities have been reported. Peripheral blood T lymphocytes from patients with common variable immunodeficiency (CVID) and blood donors were examined for expression of CD8alpha, CD8beta and CD28. In CVID, three CD8+ T cells could be defined: CD8beta(high)CD28+ (expressing CD8beta at a...

journal_title：Immunobiology

authors： Werwitzke S,Drescher B,Schmidt RE,Witte T

更新日期：2000-08-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is an environmental sensor and ligand-activated transcription factor that is critically involved in the regulation of inflammatory responses and the induction of tolerance by modulating immune cells. As dendritic cells (DCs) express high AhR levels, they are efficient to induce immu...

journal_title：Immunobiology

authors： Michalski J,Deinzer A,Stich L,Zinser E,Steinkasserer A,Knippertz I

更新日期：2020-07-01 00:00:00

abstract：:Living organisms have strong defense mechanisms against invading microorganisms as survival strategies. One of the defense mechanisms is the complement system, composed of more than 30 serum and cell surface components. This system collaborates in recognition and elimination of pathogens as a part of both the innate a...

journal_title：Immunobiology

authors： Endo Y,Takahashi M,Fujita T

更新日期：2006-01-01 00:00:00

abstract：:Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...

journal_title：Immunobiology

authors： De Schryver M,Leemans A,Pintelon I,Cappoen D,Maes L,Caljon G,Cos P,Delputte PL

更新日期：2017-06-01 00:00:00

abstract：:Immunosuppressive effects of corticosteroids are generally known, but the mechanisms influencing the immune system are poorly understood. However, a correlation between cortisol levels and cytokine production has been reported by several investigators. In the present study we determined cortisol concentrations in huma...

journal_title：Immunobiology

authors： Reissland P,Wandinger KP

更新日期：1999-06-01 00:00:00

abstract：:Autoantibodies against DNA topoisomerase I (anti-topo I) have been reported to be specific to systemic sclerosis (SSc), however, anti-topo I was detected in patients with silicone breast implants, SLE without features of SSc, and rheumatic diseases. We detected anti-topo I positive silicosis patients without any sympt...

journal_title：Immunobiology

authors： Ueki A,Isozaki Y,Tomokuni A,Ueki H,Kusaka M,Tanaka S,Otsuki T,Sakaguchi H,Hyodoh F

更新日期：2001-12-01 00:00:00

abstract：:Cytotoxicity and production of cytokines are two important functions of NK cells. These two different NK functions were studied in a syngeneic rat model in relation to MHC class I expression. We focussed on the mechanism by which NK cells modulate MHC class I expression on target cells and how this interferes with NK ...

journal_title：Immunobiology

authors： Jonges LE,Giezeman-Smits KM,van Vlierberghe RL,Ensink NG,Hagenaars M,Joly E,Eggermont AM,van de Velde CJ,Fleuren GJ,Kuppen PJ

更新日期：2000-11-01 00:00:00

abstract：:A mouse ear reaction for testing cell mediated immunity of human lymphocytes using the local graft-versus-host reaction assay is described. Five million human mononuclears were locally injected into the ears of immune suppressed NZW mice. The reaction mounted was quantitated by determining the 125I-Iodo-Deoxyuridine (...

journal_title：Immunobiology

authors： Mukamel E,Umiel T,Shohat B,Pecht M,Servadio C,Trainin N

更新日期：1985-02-01 00:00:00