Abstract:
:In a subgroup of CVID T cell abnormalities have been reported. Peripheral blood T lymphocytes from patients with common variable immunodeficiency (CVID) and blood donors were examined for expression of CD8alpha, CD8beta and CD28. In CVID, three CD8+ T cells could be defined: CD8beta(high)CD28+ (expressing CD8beta at a high median fluorescence intensity), CD8beta(low)CD28+ and CD8beta(low) CD28- cells. The number of CD8beta(low) cells was markedly increased compared to blood donors. After activation, CD8beta(high)CD28+ cells from cord blood differentiated into CD8beta(low) CD28- cells. Therefore, CD8beta(low) cells are induced by activation even in normal donors, but may reflect inflammatory activity in CVID.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Werwitzke S,Drescher B,Schmidt RE,Witte Tdoi
10.1016/S0171-2985(00)80062-5subject
Has Abstractpub_date
2000-08-01 00:00:00pages
168-71issue
2eissn
0171-2985issn
1878-3279pii
S0171-2985(00)80062-5journal_volume
202pub_type
杂志文章相关文献
IMMUNOBIOLOGY文献大全abstract::We studied immunohistological and biochemical aspects of the CD44 molecule with a mAb produced in our lab: GRHL-1. The characteristic expression of this antigen in cells of B lineage was analyzed. This mAb showed identical immunohistological patterns of reactivity to other mAbs included in CD44 cluster, on a variety l...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80181-6
更新日期:1991-09-01 00:00:00
abstract::Mast cells serve important roles as sentinels against bacterial infection by secreting mediators stored in granules. Much of their effectiveness depends upon recruiting and/or modulating other immune cells. The location of mast cells implies that they recognize pathogens invading tissues or mucosal tissues. Acinetobac...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.05.015
更新日期:2017-11-01 00:00:00
abstract::Intestinal epithelial cells produce cytokines in response to bacterial peptidoglycan (PGN), which is detected by several classes of pattern-recognition receptors (PRRs) as peptidoglycan recognition proteins (PGlyRPs), Toll-like receptor 2 (TLR2) and NOD receptors. All types of PGlyRPs recognize bacterial peptidoglycan...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2011.10.013
更新日期:2012-04-01 00:00:00
abstract::The majority of B lymphocytes, virgin T lymphocytes and a subpopulation of memory T cells express the addressin, L-selectin. Natural killer (NK) cells in rodents and humans also express L-selectin. We have shown that a similar proportion (40%) of NK cells in mouse spleen also express the integrin, CD18Mac-1, and moreo...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1078/0171-2985-00220
更新日期:2003-01-01 00:00:00
abstract::In contrast to murine spleen M phi, resident peritoneal M phi from health mice express very little Forssman glycolipid antigen (Fo). The following experiments suggest that Fo expression by peritoneal M phi may be associated with inflammation. Balb/c and CBA/J mice were given inflammatory stimuli by i.p. injection of l...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(11)80302-5
更新日期:1990-06-01 00:00:00
abstract::L-alanine was shown earlier to play a significant role for the proliferation of lymphocytes in vitro. In the present work the effect of L-alanine and some other amino acids on thymocyte proliferation was studied in vivo by local administration into one thymus lobe of guinea pigs. Proliferating cells were pulse labelle...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(11)80487-0
更新日期:1993-06-01 00:00:00
abstract::BCG infection of mice provides a convenient model to study natural and cellular immunity to mycobacteria and the mechanisms of granuloma formation and repair. We have used a range of macrophage (M phi) membrane molecules and secretory products to investigate resident M phi-pathogen interactions and T lymphocyte-depend...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/S0171-2985(11)80442-0
更新日期:1994-10-01 00:00:00
abstract::Polyclonally activated lymphoblasts, transferred to syngeneic recipient mice, elicited a host T-cell-mediated "response" in vivo. These T cells, which "responded" in vivo to syngeneic lymphoblasts (i.e. in vivo primed "responder" T-cell population), acquired the capacity to "stimulate" a "response" of syngeneic T cell...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(80)80015-5
更新日期:1980-12-01 00:00:00
abstract::Complement assays have for many years utilised buffers based on barbitone (veronal) despite the well-recognised toxicity of this agent and the tight regulations on its use in most countries. The use of barbitone in complement assay buffers is steeped in history, from a time when no other suitable buffers were availabl...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2018.07.016
更新日期:2018-12-01 00:00:00
abstract::Macrophage pre-treatment with bacterial lipopolysaccharide (LPS) boosts subsequent activation of the NLRP3 inflammasome, which controls caspase-1-dependent pro-inflammatory cytokine maturation. Previous work has attributed this phenomenon (known as LPS 'priming') to LPS-dependent induction of NLRP3 expression. Whilst ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2012.07.020
更新日期:2012-12-01 00:00:00
abstract::The defective antigen presenting ability of antigen presenting cells (APCs) modulates host cytokines and co-stimulatory signals that may lead to severity of leprosy. In the present study, we sought to evaluate the phenotypic features of APCs along with whether DC SIGN (DC-specific intercellular adhesion molecule-grabb...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2013.05.004
更新日期:2013-12-01 00:00:00
abstract::Recently, it could be shown that Cyclosporin A (CsA) inhibited the activation of T and B lymphocytes by interfering with an early step of the activation, namely the stimulation of the plasma membrane-bound lysophosphatide acyltransferase. In this report, we compared three CsA-derivatives, Dihydro-Cyclosporin C (Dihydr...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(87)80025-6
更新日期:1987-09-01 00:00:00
abstract::The inhibitory anti-CTLA-4 antibody, ipilimumab, dramatically improved survival in a subgroup of metastatic melanoma patients. The majority, however, suffered autoimmune-related adverse events (irAEs), sometimes pathognomonic of acute graft-versus-host-disease (GVHD). This implies that the CTLA-4 blockade is not tumor...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2014.11.019
更新日期:2015-05-01 00:00:00
abstract::CD147 is a broadly expressed cell surface molecule of the immunoglobulin superfamily whose expression is up-regulated upon T cell activation. Engagement of CD147 by CD147 monoclonal antibodies (mAbs) has been shown to induce homotypic aggregation of U937 cells. To study intracellular signal transduction induced by the...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(01)80015-2
更新日期:2001-05-01 00:00:00
abstract::Splenic B cells of BALB/c mice were stimulated in vitro either with lipopolysaccharide (LPS), dextran sulphate (DxS), or with both LPS and DxS. The absolute frequency of B cells that differentiate into clones of immunoglobulin (Ig)-secreting cells upon activation with these mitogens was determined by means of limiting...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(88)80060-3
更新日期:1988-02-01 00:00:00
abstract::Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(81)80014-9
更新日期:1981-06-01 00:00:00
abstract::The prevailing paradigm defines sarcoidosis as a disease of unknown etiology characterized by a systemic noncaseating epithelioid granulomatous response (SGR). This formulation fails to account for the elusiveness of the etiological agent, the nature of the Kveim response, the paradox of cutaneous delayed type hyperse...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2016.12.005
更新日期:2017-04-01 00:00:00
abstract::We utilized antisera specific for murine IL 1 alpha and IL 1 beta proteins to characterize cell-associated IL 1 according to two distinct criteria, immunochemical detection of radiolabeled IL 1 polypeptides and inhibition of IL 1 activity in cell lysates. Evidence is presented that IL 1 alpha and IL 1 beta are each sy...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(89)80064-6
更新日期:1989-02-01 00:00:00
abstract::LIF activity production by ConA-stimulated mononuclear cells was tested by measuring granulocyte migration from clotted plasma droplets placed in Microtest II plates. 90 min. incubation of MNC cultures with ConA assured a significant LIF activity in the 24 h. culture supernatants. Removal of the adherent cells after C...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(81)80097-6
更新日期:1981-01-01 00:00:00
abstract::The interaction between the T cell receptor (TCR) and the peptide-MHC complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC) is the main event controlling the specificity of antigen recognition by T cells. It is thought that TCR/pMHC binding kinetics are critical for the selection of ...
journal_title:Immunobiology
pub_type: 杂志文章,评审
doi:10.1016/j.imbio.2005.09.003
更新日期:2006-01-01 00:00:00
abstract::Infection of human monocytes with influenza A virus induces a broad range of proinflammatory cytokines and mononuclear cell attracting chemokines before the infected cells undergo apoptosis. The underlying mechanisms by which the corresponding genes are transcriptionally initiated after virus infection are still poorl...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/S0171-2985(97)80049-6
更新日期:1997-12-01 00:00:00
abstract:PROBLEM:NK lymphocytes play critical yet poorly defined role in implantation and during development in early pregnancy. METHODS OF STUDY:Recently, we showed that the proportion of NK that expressed CD69⁺ after incubation with K562 (CD69(stim)) cells reflected the NK population excitation potential. In the present stud...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2013.09.002
更新日期:2014-03-01 00:00:00
abstract::In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to S...
journal_title:Immunobiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.imbio.2012.05.008
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Male reproductive tract infection and inflammation are important aetiological factors of infertility. Experimental Autoimmune Orchitis (EAO) is a model of chronic inflammation useful to study mechanisms of inflammatory reactions leading to testicular impairment. EAO is characterised by interstitial cell infi...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2012.04.007
更新日期:2012-08-01 00:00:00
abstract::Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium frequently isolated from lesions of patients with localized aggressive periodontitis. Lipopolysaccharide (LPS), a major cell wall component of Gram-negative bacteria, stimulates innate immune cells via Toll-like receptor 4 (TLR4) to initiate inflammato...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2015.05.008
更新日期:2015-09-01 00:00:00
abstract::CD40 is essential for optimal B cell activation. It has been shown that CD40 stimulation can augment BCR-induced B cell responses, but the molecular mechanism(s) by which CD40 regulates BCR signaling is poorly understood. In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2010.09.016
更新日期:2011-05-01 00:00:00
abstract::Although there have been numerous attempts to develop a successful vaccine against leishmaniasis, based on the clinical trial in this field, no vaccine against Leishmania in routine way can be found for globally effective vaccination in human. Amongst, first generation vaccines consisting of parasite fractions or whol...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2017.12.003
更新日期:2018-01-01 00:00:00
abstract::Antibody-mediated elimination of foreign antigens contributes to immune protection from viral infection. We have generated phycoerythrin-conjugated HIV-1 Gag/p24 and influenza virus nucleoprotein tetramers for flow cytometric analysis of blood cell populations involved in antibody-mediated immunity. We show that in th...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2009.02.004
更新日期:2010-03-01 00:00:00
abstract::Mugwort pollen allergy is frequent in parts of Europe. As mugwort pollen contains only one major allergen, Art v 1, which harbors only one T cell epitope, we employed mugwort pollen allergy as a model to study allergen-specific T cell responses. However, after 2004, we noticed a drastic decrease in the T cell response...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/j.imbio.2019.07.003
更新日期:2019-09-01 00:00:00
abstract::Cytotoxicity and production of cytokines are two important functions of NK cells. These two different NK functions were studied in a syngeneic rat model in relation to MHC class I expression. We focussed on the mechanism by which NK cells modulate MHC class I expression on target cells and how this interferes with NK ...
journal_title:Immunobiology
pub_type: 杂志文章
doi:10.1016/s0171-2985(00)80037-6
更新日期:2000-11-01 00:00:00