"Self-reactive" T cells. III. In vitro restimulation of T cells, "responding" in vivo or in vitro to syngeneic lymphoid cells.

abstract：:The mechanisms of tolerance induction occurring in the course of allergen-specific immunotherapy have not been elucidated in full detail. Our study aimed to characterize high zone tolerance in mouse models of type I allergy and of allergic airway inflammation induced by subcutaneous sensitization of mice with high dos...

journal_title：Immunobiology

authors： Raker V,Stein J,Montermann E,Maxeiner J,Taube C,Reske-Kunz AB,Sudowe S

更新日期：2015-04-01 00:00:00

abstract：:Dendritic cells (DCs) are potent antigen-presenting cells that initiate the primary immune response and whose functional properties in vivo depend on the maturation stimulus. We describe the functional properties of human monocyte-derived DCs after the maturation of immature DCs (iDCs) for 2 days with LPS (100 ng/ml),...

journal_title：Immunobiology

authors： da Silva I,Gomes GG,Menezes CC,Palma PV,Orellana MD,Covas DT,Chammas R,Greene LJ

更新日期：2013-02-01 00:00:00

abstract：:Previous work has shown that purified rat macrophages lack both accessory activity for T lymphocyte responses to mitogens and stimulatory activity in a mixed leukocyte reaction, in marked contrast to the potent activity of dendritic cells. This study was designed to re-evaluate macrophages as accessory cells by treati...

journal_title：Immunobiology

authors： Bowers WE,Ruhoff MS,Goodell EM,Stoltenborg JK

更新日期：1988-02-01 00:00:00

abstract：:The vitamin D receptor (VDR) is a hormone nuclear receptor regulating bone and calcium homeostasis. Studies revealing the expression of VDR on immune cells point toward a role for VDR-dependent signaling pathways in immunity. Here we verified the ability of the natural VDR ligand, 1,25-dihydroxyvitamin D(3) (1,25(OH)(...

journal_title：Immunobiology

authors： Korf H,Wenes M,Stijlemans B,Takiishi T,Robert S,Miani M,Eizirik DL,Gysemans C,Mathieu C

更新日期：2012-12-01 00:00:00

abstract：:Cartilage-hair hypoplasia (CHH), or McKusick type metaphyseal chondrodysplasia, was first recognized as a distinct entity in the Old Order Amish in the USA, but was later identified in other groups, and found to be unusually frequent among Finns. CHH is highly pleiotropic with manifestations that include short stature...

journal_title：Immunobiology

authors： Muñoz-Robles J,Allende LM,Clemente J,Calleja S,Varela P,Gonzalez L,de Pablos P,Paz E,Morales P

更新日期：2006-01-01 00:00:00

abstract：:CD40 is essential for optimal B cell activation. It has been shown that CD40 stimulation can augment BCR-induced B cell responses, but the molecular mechanism(s) by which CD40 regulates BCR signaling is poorly understood. In this report, we attempted to characterize the signaling synergy between BCR- and CD40-mediated...

journal_title：Immunobiology

authors： Ying H,Li Z,Yang L,Zhang J

更新日期：2011-05-01 00:00:00

abstract：:Non-antigen-specific activation of human B lymphocytes for IgE production in vitro requires the presence of interleukin 4 and non-cognate physical interaction with T cells. The latter can be replaced by antibodies directed against the B cells' CD40 structure. Antigen-specific induction of immunoglobulin responses, inc...

journal_title：Immunobiology

authors： Armerding D,van Reijsen FC,Hren A,Mudde GC

更新日期：1993-07-01 00:00:00

abstract：:In bitches, the onset of pyometra, an infection of the uterus, characteristically occurs in the first half of the diestrous stage in the estrous cycle, in which the blood concentration of progesterone peaks and that of estradiol-17beta is lowest. To investigate the immunological mechanisms governing stage-specific ons...

journal_title：Immunobiology

authors： Sugiura K,Nishikawa M,Ishiguro K,Tajima T,Inaba M,Torii R,Hatoya S,Wijewardana V,Kumagai D,Tamada H,Sawada T,Ikehara S,Inaba T

更新日期：2004-01-01 00:00:00

abstract：:Cytophotometric measurements of DNA, dry mass (total proteins) and surface localized IgM and Ia were performed on individual cells of a Burkitt lymphoma derived cell line after X-irradiation and after polyploidization. Blockage of cell division was achieved with 250 r, and an arrest in G2 was found 48 hr after irradia...

journal_title：Immunobiology

authors： Killander D,Klein E,Shapiro I,Lundin L

更新日期：1980-07-01 00:00:00

abstract：:OK-432, a streptococcal preparation, has been shown as an effective activator to induce human monocyte-derived dendritic cells maturation. During this process, the activation of Toll-like receptor 4 plays an important role. However, the signaling pathway involved in has not been fully understood. In the present study,...

journal_title：Immunobiology

authors： Pan K,Wang H,Liu WL,Zhang HK,Zhou J,Li JJ,Weng DS,Huang W,Sun JC,Liang XT,Xia JC

更新日期：2009-01-01 00:00:00

abstract：:Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effec...

journal_title：Immunobiology

authors： Worthington JJ,Fenton TM,Czajkowska BI,Klementowicz JE,Travis MA

更新日期：2012-12-01 00:00:00

abstract：:C1q binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. C1q binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology o...

journal_title：Immunobiology

authors： Sim RB,Kishore U,Villiers CL,Marche PN,Mitchell DA

更新日期：2007-01-01 00:00:00

abstract：:Toll-like receptors (TLR) initiate innate and often affect adaptive immune response. This study aimed to determine if TLR response and T regulatory cell (Treg) function in peripheral blood mononuclear cells (PBMC) correlate with clinical severity in non-infectious asthma. TLR1-9 expression and representative response ...

journal_title：Immunobiology

authors： Lee WI,Yao TC,Yeh KW,Chen LC,Ou LS,Huang JL,PATCH Study Group.

更新日期：2013-02-01 00:00:00

abstract：:Interleukin-7 (IL-7) supports the proliferation of mature T lymphocytes, however, the cellular source of IL-7 for T lymphocyte activation has not been well established. We therefore investigated whether human peripheral blood dendritic cells (DC) produce IL-7 as a contribution towards T lymphocyte activation. Human CM...

journal_title：Immunobiology

authors： Sorg RV,McLellan AD,Hock BD,Fearnley DB,Hart DN

更新日期：1998-03-01 00:00:00

abstract：:IL-33 targeting ST2 receptor (T1/ST2), expressed on Th2 cell surface, regulates the production of cytokines like IL-17A and IL-31. We studied the role of IL-33/ST2 axis in IL-31 and IL-17A production in patients with allergic rhinitis (AR) and with concomitant allergic asthma and rhinitis (AAR). 20 healthy control sub...

journal_title：Immunobiology

authors： Vocca L,Di Sano C,Uasuf CG,Sala A,Riccobono L,Gangemi S,Albano GD,Bonanno A,Gagliardo R,Profita M

更新日期：2015-08-01 00:00:00

abstract：:Numerous studies have shown that over-activation of microglia could cause neuroinflammation and release pro-inflammatory mediators, which could result in neurodegenerative diseases, like Parkinson's disease, Alzheimer's disease etc. Beta-naphthoflavone (BNF) has anti-oxidant and anti-inflammatory effects in borderline...

journal_title：Immunobiology

authors： Gao X,He D,Liu D,Hu G,Zhang Y,Meng T,Su Y,Zhou A,Huang B,Du J,Fu S

更新日期：2020-07-01 00:00:00

abstract：:CD8-positive cytotoxic T cells (CTL) recognize antigenic peptides in combination with major histocompatibility complex (MHC) class I molecules on the surface of syngeneic antigen presenting cells (APC). In the present paper we show that cells from tumor antigen-specific CTL clones present their cognate antigenic pepti...

journal_title：Immunobiology

authors： Staege MS,Schneider J,Eulitz M,Scholz S,Bornkamm GW,Wölfel T,Reske-Kunz AB

更新日期：2000-01-01 00:00:00

abstract：:The homotypic cell aggregation of leukocytes is an unique adhesive event which is caused by cellular activation. Anti-CD44 monoclonal antibody (mAb) induces homotypic cell aggregation of hematopoietic cell lines expressing CD44, but the mechanism of homotypic cell aggregation is poorly understood. We used four mAbs ag...

journal_title：Immunobiology

authors： Cao L,Yoshino T,Nishiuchi R,Yamadori I,Akagi T

更新日期：1995-06-01 00:00:00

abstract：:This study assessed variation in plasma levels of the complement regulatorC1 inhibitor (C1inh) in patients with age related macular degeneration (AMD) and controls. Plasma from391 AMD cases and 370 controls was assayed by rate nephelometry to determine C1inh protein levels. Protein levels were analysed for relationshi...

journal_title：Immunobiology

authors： Gibson J,Hakobyan S,Cree AJ,Collins A,Harris CL,Ennis S,Morgan BP,Lotery AJ

更新日期：2012-02-01 00:00:00

abstract：:A C1q receptor that upregulates the phagocytic capacity of professional phagocytes, C1qRp, has been identified, and its primary structure determined by cDNA cloning and sequencing. Monoclonal antibodies that immunoprecipitate this 126,000 Mr polypeptide inhibit the enhancement of phagocytosis triggered not only by C1q...

journal_title：Immunobiology

authors： Tenner AJ

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Analysis of peripheral blood lymphocyte subsets has become an essential tool in the evaluation of outcome of diagnostic and research related questions in immunological and pathological conditions. Periodic evaluation and establishment of normal lymphocyte reference ranges are required in clinical and researc...

journal_title：Immunobiology

authors： Valiathan R,Deeb K,Diamante M,Ashman M,Sachdeva N,Asthana D

更新日期：2014-07-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells capable of abrogating T and B cells responses and have been identified in numerous cancers. As with other regulatory cell populations, they aim to maintain balance between host-defence-associated inflammation and ensuing tissue pathology. MDSC accumulati...

journal_title：Immunobiology

authors： Tamadaho RSE,Hoerauf A,Layland LE

更新日期：2018-01-01 00:00:00

abstract：:It is established that (1) subclinical Bordetella pertussis colonization of the nasopharynx persists in highly vaccinated populations, and (2) B. pertussis toxin is a potent adjuvant that, when co-administered with neural antigens, induces neuropathology in experimental autoimmune encephalomyelitis, the principle anim...

journal_title：Immunobiology

authors： Rubin K,Glazer S

更新日期：2016-04-01 00:00:00

abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is a primary immunodeficiency caused by impaired Fas/FasL-mediated apoptosis of lymphocytes and is characterized by chronic nonmalignant or benign lymphoproliferation, autoimmune manifestations and expansion of double negative (DN) T-cells (TCRαβ+CD4-CD8-). Most cases of ...

journal_title：Immunobiology

authors： Martínez-Feito A,Melero J,Mora-Díaz S,Rodríguez-Vigil C,Elduayen R,González-Granado LI,Pérez-Méndez D,Sánchez-Zapardiel E,Ruiz-García R,Menchén M,Díaz-Madroñero J,Paz-Artal E,Del Orbe-Barreto R,Riñón M,Allende LM

更新日期：2016-01-01 00:00:00

abstract：:The goal of our work was to titer the IgG, IgM and IgA in Pentaglobin® (a preparation enriched in IgM), targeting specific surface antigens of Gram-positive and Gram-negative bacteria as well as a C. albicans strain. Lipopolysaccharides from Gram-negative bacteria, peptidoglycan and lipoteichoic acid from the other mi...

journal_title：Immunobiology

authors： Stracquadanio S,Lo Verde F,Cialfi A,Zega A,Stefani S,Cafiso V

更新日期：2020-03-01 00:00:00

abstract：:This paper describes the characteristics of T suppressor inducer (Ts ind) cells which can interact with T suppressor effector (Ts eff) cells and thereby can account for suppression of delayed-type hypersensitivity (DTH) to alloantigens. Adoptive transfer of spleen cells from mice intravenously (i.v.) injected with all...

journal_title：Immunobiology

authors： Molendijk A,van Gurp RJ,Knulst AC,Benner R

更新日期：1989-03-01 00:00:00

abstract：:Exposure of resident peritoneal macrophages or thioglycollate-induced macrophages (TG-Mø) to influenza or Sendai virus-infected spleen cell culture supernatants (MAS) resulted in macrophage activation. When normal resident macrophages were used as effector cells, both infected P815 and L929 cells were lysed in the pre...

journal_title：Immunobiology

authors： Mak NK,Ada GL

更新日期：1984-05-01 00:00:00

abstract：:In the thymus of non-obese diabetic (NOD) mice, the expression of the autoimmune regulator (Aire) gene varies with age, and its down-regulation in young mice precedes the later emergence of type 1 diabetes mellitus (T1D). In addition, the insulin (Ins2) peripheral tissue antigen (PTA) gene, which is Aire-dependent, is...

journal_title：Immunobiology

authors： Oliveira EH,Macedo C,Donate PB,Almeida RS,Pezzi N,Nguyen C,Rossi MA,Sakamoto-Hojo ET,Donadi EA,Passos GA

更新日期：2013-01-01 00:00:00

abstract：:In the last decade new glucocorticoid (GC)-signalling mechanisms have emerged. The evolving field of non-genomic GC actions was precipitated from two major directions: (i) some rapid/acute clinical GC applications could not be explained based on the relatively slowly appearing genomic GC action and (ii) accumulating e...

journal_title：Immunobiology

authors： Boldizsar F,Talaber G,Szabo M,Bartis D,Palinkas L,Nemeth P,Berki T

更新日期：2010-07-01 00:00:00

abstract：:Intraepithelial intestinal T lymphocytes (IEL) bearing alpha beta or gamma delta T cell receptors (TCR) are positioned to serve as a first line of defense against enteric pathogens. To investigate whether intestinal IEL are subject to antigenic selective forces distinct from that influencing (xp T cells in the periphe...

journal_title：Immunobiology

authors： Pluschke G,Taube H,Krawinkel U,Pfeffer K,Wagner H,Classen M,Deusch K

更新日期：1994-12-01 00:00:00