当前位置： SCI文献检索 > IMMUNOBIOLOGY期刊下所有文献 > MHC- and Igh-unrestricted interaction between L3T4+, Lyt-2- Ts inducer cells and L3T4-, Lyt-2+ Ts effector cells is required for T cell-dependent suppression of DTH to histocompatibility antigens.

MHC- and Igh-unrestricted interaction between L3T4+, Lyt-2- Ts inducer cells and L3T4-, Lyt-2+ Ts effector cells is required for T cell-dependent suppression of DTH to histocompatibility antigens.

Abstract：

:This paper describes the characteristics of T suppressor inducer (Ts ind) cells which can interact with T suppressor effector (Ts eff) cells and thereby can account for suppression of delayed-type hypersensitivity (DTH) to alloantigens. Adoptive transfer of spleen cells from mice intravenously (i.v.) injected with allogeneic spleen cells one day earlier induced an antigen-specific state of suppression in the recipients. This became apparent when DTH was induced by subcutaneous (s.c.) immunization of the recipients three days after transfer. The induction of suppression after adoptive transfer of spleen cells required Thy-1+, L3T4+, Lyt-1+2- cells. These cells that by themselves did not exert a suppressive effect induced a state of suppression in recipient mice by activation of recipient-type Ts eff cells. Therefore, the former cell type was classified as Ts ind cell. When athymic nude mice were used as recipients, Lyt-2+ precursors of Ts eff cells had to be transferred together with the Ts ind cells to induce a state of suppression in these mice. The Ts ind cells could activate Ts eff cells in MHC- and Igh-incompatible recipients. The results are discussed in relation to previously described immunoregulatory T cell pathways.

journal_name

Immunobiology

journal_title

Immunobiology

authors

Molendijk A,van Gurp RJ,Knulst AC,Benner R

doi

10.1016/s0171-2985(89)80007-5

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

56-67

issue

1

eissn

0171-2985

issn

1878-3279

pii

S0171-2985(89)80007-5

journal_volume

179

pub_type

杂志文章

相关文献

IMMUNOBIOLOGY文献大全
  • The pivotal role of p38 and NF-kappaB signal pathways in the maturation of human monocyte-derived dendritic cells stimulated by streptococcal agent OK-432.

    abstract：:OK-432, a streptococcal preparation, has been shown as an effective activator to induce human monocyte-derived dendritic cells maturation. During this process, the activation of Toll-like receptor 4 plays an important role. However, the signaling pathway involved in has not been fully understood. In the present study,...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2008.10.008

    authors： Pan K,Wang H,Liu WL,Zhang HK,Zhou J,Li JJ,Weng DS,Huang W,Sun JC,Liang XT,Xia JC

    更新日期：2009-01-01 00:00:00

  • Characterization of suppressor T cells in graft-versus-host reactions.

    abstract：:Intravenous (i.v.) immunization of mice with irradiated (2000 rads) allogeneic lymphoid cells induces the generation of suppressor T cells. Such suppressor T cells can suppress the anti-host delayed type hypersensitivity (DTH) by other T cells during acute Graft-versus-Host reactions in irradiated recipient mice. Supp...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(85)80035-8

    authors： Bril H,Molendijk-Lok BD,Hussaarts-Odijk LM,Benner R

    更新日期：1985-04-01 00:00:00

  • Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF.

    abstract：:Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activat...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.06.006

    authors： Nymo S,Niyonzima N,Espevik T,Mollnes TE

    更新日期：2014-10-01 00:00:00

  • Myeloid arginase-1 controls excessive inflammation and modulates T cell responses in Pseudomonas aeruginosa pneumonia.

    abstract：:Regulatory properties of macrophages associated with alternative activation serve to limit the exaggerated inflammatory response during pneumonia caused by Pseudomonas aeruginosa infection. Arginase-1 is an important effector of these macrophages believed to play an essential role in decreasing injury and promoting re...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2020.152034

    authors： Haydar D,Gonzalez R,Garvy BA,Garneau-Tsodikova S,Thamban Chandrika N,Bocklage TJ,Feola DJ

    更新日期：2020-11-24 00:00:00

  • The dopamine D3 receptor regulates the effects of methamphetamine on LPS-induced cytokine production in murine mast cells.

    abstract：:Previous studies have demonstrated that methamphetamine (METH) alter inflammatory and anti-inflammatory cytokine production in the periphery. However, the effect of METH on lipopolysaccharide (LPS)-induced immune responses and its underlying mechanism of action remains unclear. The dopamine D3 receptor (D3R) plays an ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.12.021

    authors： Xue L,Li X,Ren HX,Wu F,Li M,Wang B,Chen FY,Cheng WY,Li JP,Chen YJ,Chen T

    更新日期：2015-06-01 00:00:00

  • Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients.

    abstract：:T-lymphocytes, including Th17-cells and T-cells expressing acetylcholine (ACh), are key components of systemic inflammation in chronic obstructive pulmonary disease (COPD). We investigated whether ACh promotes Th17 cells in COPD. ACh, IL-17A, IL-22, RORγt, FOXP3 expression and AChIL-17A, AChIL-22, AChRORγt coexpressio...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.01.004

    authors： Profita M,Albano GD,Riccobono L,Di Sano C,Montalbano AM,Gagliardo R,Anzalone G,Bonanno A,Pieper MP,Gjomarkaj M

    更新日期：2014-05-01 00:00:00

  • Activation of the first component of complement, C1: comparison of the effect of sixteen different enzymes on serum C1.

    abstract：:In this study, the effect of sixteen different enzymes on serum C1 and its subcomponents was investigated. The sixteen enzymes could be divided into three groups. First, enzymes which activate native C1: trypsin (optimal concentration 2.4 x 10(-4) mM); alpha-chymotrypsin (2.3 x 10(3) mM); thrombin (1.0 x 10(-5) mM); p...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(83)80058-8

    authors： Heinz HP,Loos M

    更新日期：1983-08-01 00:00:00

  • Leucine rich repeats and calponin homology domain containing 1 inhibits NK-92 cell cytotoxicity through attenuating Src signaling.

    abstract：:NK-92 cell line has been used as anti-tumor cytotoxic effector cells in immunotherapy. Leucine-rich repeats and calponin homology domain containing 1 (LRCH1) is a novel gene of which the function is unclear. In the present study, we investigated the role of LRCH1 in NK-92 cell cytotoxicity. LRCH1 was ablated in NK-92 ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2020.151934

    authors： Dai K,Chen Z,She S,Shi J,Zhu J,Huang Y

    更新日期：2020-05-01 00:00:00

  • The course of Legionella pneumonia in guinea pigs after inhalation of various quantities of L. pneumophila.

    abstract：:The course of legionella pneumonia in guinea pigs after infection with various quantities of virulent L. pneumophila serogroup 1 organisms by aerosol exposure was investigated. The clinical course, histopathological characteristics, manifestations in the lungs and clearance of the legionella organisms from the lungs a...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(87)80104-3

    authors： Twisk-Meijssen MJ,Meenhorst PL,van Cronenburg BJ,Mulder JD,Scheffer E,van Furth R

    更新日期：1987-12-01 00:00:00

  • Multiorgan failure and antiphospholipid antibodies: the catastrophic antiphospholipid (Asherson's) syndrome.

    abstract：:A review of 250 patients with the catastrophic antiphospholipid (Asherson's) syndrome (CAPS) taken from the web site organized by the Europhospholipid Group (http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) is presented in this paper. A short historical overview of the antiphospholipid syndrome (APS) is followed by a descr...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2005.10.002

    authors： Asherson RA

    更新日期：2005-01-01 00:00:00

  • Carbohydrate surface constituents of T cells mediating delayed-type hypersensitivity that control entry into sites of antigen deposition.

    abstract：:Peritoneal exudate T lymphocytes (PETLs) that mediate delayed-type hypersensitivity (DTH) to sheep red blood cells in mice were modified by in vitro treatment methods which modify surface carbohydrate constituents. Neuraminidase treatment resulted in the release of both N-acetylneuraminic acid and N-glycolyl-neuramini...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(81)80046-0

    authors： Kaufmann SH,Schauer R,Hahn H

    更新日期：1981-01-01 00:00:00

  • An advanced approach for the characterization of dendritic cell-induced T cell proliferation in situ.

    abstract：:It is commonly accepted that dendritic cells (DCs) play a pivotal role in the induction of adaptive T cell-mediated immune responses. The clonal expansion of antigen-specific T cells within secondary lymphoid organs reflects the efficiency of antigen processing and presentation by DCs. Consequently, the quantification...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2010.05.017

    authors： Florian C,Barth T,Wege AK,Männel DN,Ritter U

    更新日期：2010-09-01 00:00:00

  • Regulation of expression of the LFA-1 and p150,95 leukocyte integrins: involvement of the CD11a and CD11c gene promoters.

    abstract：:Human Lymphocyte Associated Antigen-1 (LFA-1, CD11a/CD18, alpha L/beta 2) and p150,95 (CD11c/CD18, alpha X/beta 2) are cell surface alpha/beta heterodimers that, together with Mac-1 (CD11b/CD18, alpha M/beta 2) comprise the leukocyte-restricted beta 2 subfamily of integrins. LFA-1 is the only integrin expressed on all...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/s0171-2985(11)80560-7

    authors： López-Rodríguez C,Nueda A,Rubio M,Corbí AL

    更新日期：1995-07-01 00:00:00

  • Dipeptidyl peptidase IV (CD26) on human lymphocytes. Synthetic inhibitors of and antibodies against dipeptidyl peptidase IV suppress the proliferation of pokeweed mitogen-stimulated peripheral blood mononuclear cells, and IL-2 and IL-6 production.

    abstract：:In the present report, we describe that synthetic inhibitors of and polyclonal and monoclonal antibodies against the membrane ectoenzyme dipeptidyl peptidase IV (DP IV, CD26) inhibit the production of IL-2 and IL-6 and, concomitantly, DNA synthesis of pokeweed mitogen-stimulated peripheral blood mononuclear cells (PBM...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80223-8

    authors： Reinhold D,Bank U,Bühling F,Neubert K,Mattern T,Ulmer AJ,Flad HD,Ansorge S

    更新日期：1993-08-01 00:00:00

  • Autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline caspase-10 (CASP10) variation.

    abstract：:Autoimmune lymphoproliferative syndrome (ALPS) is a primary immunodeficiency caused by impaired Fas/FasL-mediated apoptosis of lymphocytes and is characterized by chronic nonmalignant or benign lymphoproliferation, autoimmune manifestations and expansion of double negative (DN) T-cells (TCRαβ+CD4-CD8-). Most cases of ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2015.08.004

    authors： Martínez-Feito A,Melero J,Mora-Díaz S,Rodríguez-Vigil C,Elduayen R,González-Granado LI,Pérez-Méndez D,Sánchez-Zapardiel E,Ruiz-García R,Menchén M,Díaz-Madroñero J,Paz-Artal E,Del Orbe-Barreto R,Riñón M,Allende LM

    更新日期：2016-01-01 00:00:00

  • The role of matrix metalloproteinase 7 in innate immunity.

    abstract：:Matrix metalloproteinase 7 (MMP-7), or matrilysin, is a secreted protease expressed by glandular and mucosal epithelial cells, keratinocytes, fibroblasts and macrophages. As with other MMPs it can act on the extracellular matrix and thereby regulate cell migration and tissue repair. In addition, MMP-7 has an important...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.imbio.2004.04.005

    authors： Burke B

    更新日期：2004-01-01 00:00:00

  • Induction of innate immunity by Aspergillus fumigatus cell wall polysaccharides is enhanced by the composite presentation of chitin and beta-glucan.

    abstract：:Chitin and β-glucan are conserved throughout evolution in the fungal cell wall and are the most common polysaccharides in fungal species. Together, these two polysaccharides form a structural scaffold that is essential for the survival of the fungus. In the present study, we demonstrated that Aspergillus fumigatus alk...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2013.10.003

    authors： Dubey LK,Moeller JB,Schlosser A,Sorensen GL,Holmskov U

    更新日期：2014-03-01 00:00:00

  • Psoriatic inflammation causes hepatic inflammation with concomitant dysregulation in hepatic metabolism via IL-17A/IL-17 receptor signaling in a murine model.

    abstract：:Psoriatic inflammation has been shown to be associated with cardiovascular dysfunction and systemic inflammation. Recently, psoriasis has also been linked to hepatic disorders, however underlying mechanism connecting the two are unknown. IL-17A being a central pro-inflammatory cytokine in the pathogenesis of psoriasis...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2016.10.013

    authors： Al-Harbi NO,Nadeem A,Al-Harbi MM,Zoheir KMA,Ansari MA,El-Sherbeeny AM,Alanazi KM,Alotaibi MR,Ahmad SF

    更新日期：2017-02-01 00:00:00

  • LPS priming in early life decreases antigen uptake of dendritic cells via NO production.

    abstract：:Immunological mechanisms of hygiene hypothesis are expected to develop a novel strategy for allergy prevention. Although a large number of studies has investigated the relation between allergies and infection, little is known about the influence of the exposure to infections on antigen uptake by dendritic cells (DCs)....

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2017.10.018

    authors： Mizuno N,Sasaki Y,Segawa R,Asakawa S,Hiratsuka M,Hirasawa N

    更新日期：2018-01-01 00:00:00

  • Roles of cytotoxic delayed-type hypersensitivity and macrophage-activating cell-mediated immunity in the pathogenesis of tuberculosis.

    abstract：:The tubercle bacillus is a facultative intracellular parasite that grows well in non-activated macrophages. When large numbers of these bacilli have grown intracellularly within such macrophages, a cytotoxic immune response, herein called tissue-damaging (or necrotizing) delayed-type hypersensitivity (DTH), kills the ...

    journal_title：Immunobiology

    pub_type： 杂志文章,评审

    doi：10.1016/S0171-2985(11)80452-3

    authors： Dannenberg AM Jr

    更新日期：1994-10-01 00:00:00

  • Antibody response in aged C57BL/6 mice: T helper cells are responsible for the decline of the primary antibody response to a bacterial antigen in aging.

    abstract：:One of the most important effects of aging is the decline of immune effectiveness. A study is described here on the primary (IgM) antibody response to phosphorylcholine (PC), an antigen expressed on the surface of the Streptococcus pneumoniae R36a, in aged (18-22 mo.) C57BL/6 mice. Preliminary data showed a significan...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80288-3

    authors： Nicoletti C

    更新日期：1994-02-01 00:00:00

  • A novel RMRP mutation in a Spanish patient with cartilage-hair hypoplasia.

    abstract：:Cartilage-hair hypoplasia (CHH), or McKusick type metaphyseal chondrodysplasia, was first recognized as a distinct entity in the Old Order Amish in the USA, but was later identified in other groups, and found to be unusually frequent among Finns. CHH is highly pleiotropic with manifestations that include short stature...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2006.05.001

    authors： Muñoz-Robles J,Allende LM,Clemente J,Calleja S,Varela P,Gonzalez L,de Pablos P,Paz E,Morales P

    更新日期：2006-01-01 00:00:00

  • Lewis lung carcinoma cells enhance the synthesis of C3 and are opsonized by C3 secreted from murine macrophages.

    abstract：:We investigated the effect of Lewis Lung carcinoma cells on the production of C3 by murine macrophages and examined the capacity of secreted C3 to opsonize Lewis Lung carcinoma cells. C3 released in culture from macrophages obtained from tumor-bearing C57Bl/6 mice as well as from normal macrophages exposed to Lewis Lu...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(88)80043-3

    authors： Lipari M,Di Renzo L,Zicari A,Schulz TF,Magliocca A,Mardente S,Dierich MP,Pontieri GM

    更新日期：1988-07-01 00:00:00

  • Differential production of inflammatory chemokines by murine dendritic cell subsets.

    abstract：:Dendritic cells (DC) are efficient antigen presenting cells with the ability to activate naïve T cells. Murine DC represent a heterogeneous population that can be subdivided into distinct subsets, including the conventional DC (cDC) which are either CD4(-)CD8(-) (DN), CD4(+)CD8(-) (CD4+) or CD4(-)CD8(+) (CD8+) subsets...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2004.03.002

    authors： Proietto AI,O'Keeffe M,Gartlan K,Wright MD,Shortman K,Wu L,Lahoud MH

    更新日期：2004-01-01 00:00:00

  • Abnormalities of B cell activation and immunoregulation in patients with chronic inflammatory liver diseases.

    abstract：:The immunoglobulin production capacities of peripheral blood lymphocytes obtained from patients with various chronic inflammatory liver diseases and from normal individuals were compared. Using a reverse hemolytic plaque assay, immunoglobulin-secreting cells (ISC) were counted immediately after isolation (immediate IS...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(88)80066-4

    authors： Sieber G,Teichmann JV,Möller B,Hopf U

    更新日期：1988-12-01 00:00:00

  • Modulatory activity of Lactobacillus rhamnosus OLL2838 in a mouse model of intestinal immunopathology.

    abstract：:Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study,...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2015.01.004

    authors： Ogita T,Bergamo P,Maurano F,D'Arienzo R,Mazzarella G,Bozzella G,Luongo D,Sashihara T,Suzuki T,Tanabe S,Rossi M

    更新日期：2015-06-01 00:00:00

  • Partial characterization of a low molecular weight phagocytosis inhibitory factor obtained from human erythrocyte membranes.

    abstract：:Phagocytosis Inhibitory Factor (PIF), a small (< 3000 D) molecule, was partially purified from human red blood cell membranes. This factor inhibits latex phagocytosis by monocytic cells. PIF is not toxic under the experimental conditions employed and the phagocytosis inhibitory activity is reversible since removal of ...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/S0171-2985(11)80410-9

    authors： Baranyi L,Baranji K,Yoshida T,Okada N,Okada H

    更新日期：1994-12-01 00:00:00

  • Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of T cell maturation subsets in adults of South Florida.

    abstract：BACKGROUND:Analysis of peripheral blood lymphocyte subsets has become an essential tool in the evaluation of outcome of diagnostic and research related questions in immunological and pathological conditions. Periodic evaluation and establishment of normal lymphocyte reference ranges are required in clinical and researc...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2014.02.010

    authors： Valiathan R,Deeb K,Diamante M,Ashman M,Sachdeva N,Asthana D

    更新日期：2014-07-01 00:00:00

  • NK cells in patients with chronic rhinosinusitis show decreased maturity and limited expression of functional receptors.

    abstract：:Chronic rhinosinusitis is an inflammatory process of the mucous membrane of the nasal cavity and paranasal sinuses, presenting with two phenotypes that differ in symptoms and inflammatory profiles: either with or without polyps. Natural killer (NK) cells are involved in both the innate and acquired immune response, an...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2019.11.025

    authors： Kaczmarek M,Wasicka K,Tin-Tsen Chou J,Popowicz P,Rzetelska Z,Łagiedo-Żelazowska M,Piwowarczyk K,Leszczyńska M

    更新日期：2020-03-01 00:00:00

  • The immunologic properties of undifferentiated and osteogenic differentiated mouse mesenchymal stem cells and its potential application in bone regeneration.

    abstract：:The concept of using mesenchymal stem cells (MSCs) in bone repair has progressively evolved, and the goal of cell-mediated therapy is to prolong the natural physiological abilities of healing, or substitute them, when these are lacking, failing, or progressing too slowly. The future application of MSCs in human therap...

    journal_title：Immunobiology

    pub_type： 杂志文章

    doi：10.1016/j.imbio.2008.07.030

    authors： Zhang X,Tang T,Shi Q,Fernandes JC,Dai K

    更新日期：2009-01-01 00:00:00