Abstract:
:In the present report, we describe that synthetic inhibitors of and polyclonal and monoclonal antibodies against the membrane ectoenzyme dipeptidyl peptidase IV (DP IV, CD26) inhibit the production of IL-2 and IL-6 and, concomitantly, DNA synthesis of pokeweed mitogen-stimulated peripheral blood mononuclear cells (PBMC). The release of IL-1 and TNF-alpha, was not influenced under these conditions. The data support the hypothesis that DP IV, possibly in conjunction with other peptidase, is involved in the regulation of activation and proliferation of T lymphocytes.
journal_name
Immunobiologyjournal_title
Immunobiologyauthors
Reinhold D,Bank U,Bühling F,Neubert K,Mattern T,Ulmer AJ,Flad HD,Ansorge Sdoi
10.1016/S0171-2985(11)80223-8subject
Has Abstractpub_date
1993-08-01 00:00:00pages
403-14issue
4-5eissn
0171-2985issn
1878-3279pii
S0171-2985(11)80223-8journal_volume
188pub_type
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