Antibody response in aged C57BL/6 mice: T helper cells are responsible for the decline of the primary antibody response to a bacterial antigen in aging.

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease characterized by progressive airflow limitation, chronic respiratory symptoms and frequent exacerbations. There is an unmet need to identify novel therapeutic alternatives beside bronchodilators that prevent disease progression. Levels of both...

journal_title：Immunobiology

authors： Douaoui S,Djidjik R,Boubakeur M,Ghernaout M,Touil-Boukoffa C,Oumouna M,Derrar F,Amrani Y

更新日期：2020-05-01 00:00:00

abstract：:Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into...

journal_title：Immunobiology

authors： Du L,Wang S,Zhu Y,Zhao H,Basit A,Yu X,Li Q,Sun X

更新日期：2018-11-01 00:00:00

abstract：:Interleukin-6 (IL-6) induced increased, leukocyte and platelet counts on around day 20 when it was administered into [BALB/c-->C3H/He] bone marrow chimeras from day 1 to day 12. Increased leukocyte counts and hemoglobin (Hb) levels were also observed at around day 60 and from day 41 to 80, respectively. On the other h...

journal_title：Immunobiology

authors： Imamura M,Hashino S,Kobayashi H,Tanaka J,Imai K,Han M,Fujii Y,Kobayashi M,Higa T,Kasai M

更新日期：1994-06-01 00:00:00

abstract：:In a rat model, we compared the effects of various soluble products released by T cells, such as the unspecifically acting gamma-interferon or the newly detected alloantigen-induced factors that specifically act on nonlymphoid, hemopoietic bone marrow cells. We found two types of reactivity patterns with regard to the...

journal_title：Immunobiology

authors： Wottge HU,Müller-Ruchholtz W

更新日期：1987-12-01 00:00:00

abstract：:Prior work demonstrated that a splice variant of SCN5A, a voltage-gated sodium channel gene, acts as a cytoplasmic sensor for viral dsRNA in human macrophages. Expression of this channel also polarizes macrophages to an anti-inflammatory phenotype in vitro and in vivo. Here we utilized global expression analysis of sp...

journal_title：Immunobiology

authors： White CR,Dungan M,Carrithers MD

更新日期：2019-01-01 00:00:00

abstract：:Regulation of an immune response requires complex crosstalk between cells of the innate and adaptive immune systems, via both cell-cell contact and secretion of cytokines. An important cytokine with a broad regulatory role in the immune system is transforming growth factor-β (TGF-β). TGF-β is produced by and has effec...

journal_title：Immunobiology

authors： Worthington JJ,Fenton TM,Czajkowska BI,Klementowicz JE,Travis MA

更新日期：2012-12-01 00:00:00

abstract：:Lymphocytes from spleen, thymus and lymph nodes from individual young adult (3--4 months) and aged (26--30 months) NMRI mice were stimulated with the mitogens Con A, PHA and LPS. 24 hours later, the number of cell with increased RNA-content (G1 cells) was determined by cytofluorometry. In parallel the 3H-thymidine inc...

journal_title：Immunobiology

authors： Joncourt F,Bettens F,Kristensen F,de Weck AL

更新日期：1981-06-01 00:00:00

abstract：BACKGROUND:An association between Tako-Tsubo cardiomyopathy (TTC) and underlying malignancies has been observed, suggesting that TTC might be the consequence of paraneoplastic phenomena. This study investigates the presence of autoantibodies against cardiomyocytes as well as adrenergic (β1, β2) and muscarinic (M2) rece...

journal_title：Immunobiology

authors： Juenemann M,Nef H,Möllmann H,Singh P,Troidl C,Schramm P,Kaps M,Gerriets T,Blaes F,Tschernatsch M

更新日期：2019-03-01 00:00:00

abstract：:The mechanisms that mediate accelerated atherosclerosis in autoimmune diseases remain unclear. One common mechanism that has been documented in autoimmune diseases and atherosclerosis is formation of hypoglycosyalted N-glycans on the cell surface. In this study we tested the effects of swainsonine, a class II α-mannos...

journal_title：Immunobiology

authors： Scott DW,Black LL,Vallejo MO,Kabarowski JH,Patel RP

更新日期：2014-07-01 00:00:00

abstract：:Peritoneal as well as peripheral blood, but not spleen macrophages inhibit natural killer (NK) cell activity directed against adherent growing target cells. Inhibition was observed with macrophages (Mø): spleen cell ratios as low as 0.01:1. It was independent from the activation status of Mø and was not MHC restricted...

journal_title：Immunobiology

authors： Zöller M,Matzku S

更新日期：1982-12-01 00:00:00

abstract：:IgE-mediated food allergies are an important cause of life-threatening hypersensitivity reactions. Orally administered peanut antigens mixed with the mucosal adjuvant cholera toxin (CT) induce a strong peanut extract (PE)-specific serum IgE response that is correlated with T-helper type 1 (Th1) and type 2 (Th2)-like T...

journal_title：Immunobiology

authors： Fecek RJ,Marcondes Rezende M,Busch R,Hassing I,Pieters R,Cuff CF

更新日期：2010-12-01 00:00:00

abstract：:Cell walls from Streptococcus pyogenes strain Sv (Group A, M type 3) were lysed with M1 endo-N-acetylmuramidase, and the group A-specific carbohydrate antigen was purified by Sephadex G-100 gel filtration. The initial eluting antigen (M1gA) peak was assessed for mitogenic and polyclonal lymphocyte-activating propertie...

journal_title：Immunobiology

authors： Morisaki I,Kimura S,Torii M,Michalek SM,McGhee JR,Okahashi N,Hamada S

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Male reproductive tract infection and inflammation are important aetiological factors of infertility. Experimental Autoimmune Orchitis (EAO) is a model of chronic inflammation useful to study mechanisms of inflammatory reactions leading to testicular impairment. EAO is characterised by interstitial cell infi...

journal_title：Immunobiology

authors： Jarazo-Dietrich S,Jacobo P,Pérez CV,Guazzone VA,Lustig L,Theas MS

更新日期：2012-08-01 00:00:00

abstract：:LIF activity production by ConA-stimulated mononuclear cells was tested by measuring granulocyte migration from clotted plasma droplets placed in Microtest II plates. 90 min. incubation of MNC cultures with ConA assured a significant LIF activity in the 24 h. culture supernatants. Removal of the adherent cells after C...

journal_title：Immunobiology

authors： Sandru G,Veraguth P

更新日期：1981-01-01 00:00:00

abstract：:The role of the thymic microenvironment in the development of murine thymic B cells has yet to be fully clarified. We therefore investigate the microenvironment that supports the development of mature thymic B cells (sIg+/B220+/CD43-B cells) from thymic B cell progenitors with immunophenotypes of sIg-/B220med/CD43+ ce...

journal_title：Immunobiology

authors： Sugihara A,Inaba M,Mori SI,Taketani S,Adachi Y,Hisha H,Inaba K,Toki J,Horio T,Gershwin ME,Ikehara S

更新日期：2000-04-01 00:00:00

abstract：:Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activat...

journal_title：Immunobiology

authors： Nymo S,Niyonzima N,Espevik T,Mollnes TE

更新日期：2014-10-01 00:00:00

abstract：:An ELISA with covalently fixed antigens was used to measure and define ferritin-labeled antibodies. In the presented model, RIG covalently fixed to glass tubes served as antigen. Twenty ferritin-labeled SWaRIG conjugates were prepared with different molar ratios of antibody: ferritin: glutaraldehyde. At various diluti...

journal_title：Immunobiology

authors： Rauterberg EW,Schieck C,Kreft H,Römer W

更新日期：1984-05-01 00:00:00

abstract：:Gut microbiota and probiotic strains play an important role in oral tolerance by modulating regulatory and effector cell components of the immune system. We have previously described the ability of Lactobacilli to influence both the innate and adaptive immunity to wheat gluten, a food antigen, in mouse. In this study,...

journal_title：Immunobiology

authors： Ogita T,Bergamo P,Maurano F,D'Arienzo R,Mazzarella G,Bozzella G,Luongo D,Sashihara T,Suzuki T,Tanabe S,Rossi M

更新日期：2015-06-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells capable of abrogating T and B cells responses and have been identified in numerous cancers. As with other regulatory cell populations, they aim to maintain balance between host-defence-associated inflammation and ensuing tissue pathology. MDSC accumulati...

journal_title：Immunobiology

authors： Tamadaho RSE,Hoerauf A,Layland LE

更新日期：2018-01-01 00:00:00

abstract：:Chemokine CCL21 can effectively attract CCR7(+) dendritic cells (DCs), however its role in this event is poorly understood. In this report, we investigated the effect of exogenous CCL21 expressed in breast cancer MCF-7 on human monocyte-derived DCs. CCL21-transfected MCF-7 stimulation prompted DC functions: migration,...

journal_title：Immunobiology

authors： Wu S,Xing W,Peng J,Yuan X,Zhao X,Lei P,Li W,Wang M,Zhu H,Huang B,Huang L,Shen G

更新日期：2008-01-01 00:00:00

abstract：:Cytokines play critical roles in the pathogenesis of Behçet's disease (BD). They mediated many of the effectors and regulatory functions of immune and inflammatory responses. Many studies have linked Interleukin-6 (IL-6) and Interleukin-10 (IL-10) pathologically to BD. Thus, this study aimed to investigate the associa...

journal_title：Immunobiology

authors： Talaat RM,Ashour ME,Bassyouni IH,Raouf AA

更新日期：2014-08-01 00:00:00

abstract：:A review of 250 patients with the catastrophic antiphospholipid (Asherson's) syndrome (CAPS) taken from the web site organized by the Europhospholipid Group (http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) is presented in this paper. A short historical overview of the antiphospholipid syndrome (APS) is followed by a descr...

journal_title：Immunobiology

authors： Asherson RA

更新日期：2005-01-01 00:00:00

abstract：:We investigated the mRNA expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO) in human T cell lymphotropic virus type I (HTLV-I) p40tax-transfected U937 cells, a human monoblast cell line. Transfection of HTLV-I p40tax U937 cells induced up-regulation of iNOS mRNA expression and...

journal_title：Immunobiology

authors： Goto H,Nakamura T,Shirabe S,Ueki Y,Nishiura Y,Furuya T,Tsujino A,Nakane S,Eguchi K,Nagataki S

更新日期：1997-11-01 00:00:00

abstract：:Human urinary colony-stimulating factor (CSF-HU) has been partially purified using five purification procedures (preparation II) for clinical use. In phase I study, six healthy volunteers were injected with preparation II of CSF-HU by a single intravenous droplet infusion. Two volunteers received 4 X 10(6) units (U), ...

journal_title：Immunobiology

authors： Motoyoshi K,Ishizaka Y,Miura Y,Takaku F

更新日期：1986-09-01 00:00:00

abstract：:We studied immunohistological and biochemical aspects of the CD44 molecule with a mAb produced in our lab: GRHL-1. The characteristic expression of this antigen in cells of B lineage was analyzed. This mAb showed identical immunohistological patterns of reactivity to other mAbs included in CD44 cluster, on a variety l...

journal_title：Immunobiology

authors： Collado A,de Andres A,Cañadas E,Ruiz-Cabello F,Gomez O,Pedrinaci S,Garrido F

更新日期：1991-09-01 00:00:00

abstract：:The phenotype frequency of the platelet-specific antigens P1A1/A2 ( = Zw(a,b)) in the German population (N = 711) is 97.75% and 2.25% respectively. The corresponding gene frequencies are P1A1 0.85; P1A2 0.15. The P1A1 determinant is codominantly inherited (19 families; 151 family members). There is a strong gene dosag...

journal_title：Immunobiology

authors： Mueller-Eckhardt C,Marks HJ,Baur MP,Mueller-Eckhardt G

更新日期：1982-02-01 00:00:00

abstract：:Based on the similar effects that HIV-1 gp41 like human type I interferons (IFN-alpha and -beta) upregulated MHC expression and inhibited lymphocyte proliferation, we compared amino acid sequences of gp41 and human type I interferons (IFN-alpha and -beta), and found sequence-similarity existing between the immunosuppr...

journal_title：Immunobiology

authors： Chen YH,Dierich MP

更新日期：1998-02-01 00:00:00

abstract：:The goal of our work was to titer the IgG, IgM and IgA in Pentaglobin® (a preparation enriched in IgM), targeting specific surface antigens of Gram-positive and Gram-negative bacteria as well as a C. albicans strain. Lipopolysaccharides from Gram-negative bacteria, peptidoglycan and lipoteichoic acid from the other mi...

journal_title：Immunobiology

authors： Stracquadanio S,Lo Verde F,Cialfi A,Zega A,Stefani S,Cafiso V

更新日期：2020-03-01 00:00:00

abstract：:Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes internalized and this has been observed in multiple species. The latter charact...

journal_title：Immunobiology

authors： De Schryver M,Leemans A,Pintelon I,Cappoen D,Maes L,Caljon G,Cos P,Delputte PL

更新日期：2017-06-01 00:00:00

abstract：:C1q binds to many non-self and altered-self-materials. These include microorganisms, immune complexes, apoptotic and necrotic cells and their breakdown products, and amyloids. C1q binding to amyloid fibrils found as extracellular deposits in tissues, and subsequent complement activation are involved in the pathology o...

journal_title：Immunobiology

authors： Sim RB,Kishore U,Villiers CL,Marche PN,Mitchell DA

更新日期：2007-01-01 00:00:00